🧬 生物学

Metabolic Reprogramming by Time-Restricted Fasting Attenuates Astrocytic Oxidative Stress and Mitochondrial Apoptosis after Ischemic Stroke via BDH1/SLFN2/NRF2 Axis

本研究表明,限时进食通过 BDH1/SLFN2/NRF2 轴重编程代谢稳态,减轻了中风后星形胶质细胞的氧化应激和线粒体凋亡,从而增强了酮体利用,为缺血性中风恢复提供了一种潜在的治疗策略。

Han Yin, Yingying Zhang, Hui Ci, Kun Li, Haiyu Zhang, Jinrong Wu, Xinmin Zhang, Hang Yang, Qian Yu, Dandan Wang, Shansha (…)2026-10-19
🧬 生物学

Genomic signatures associated with small-scale farming landscapes in wild bee populations: potential adaptive response under high gene flow

这项研究表明,葡萄牙的小规模农业景观在三种野生蜂物种中维持着高度的遗传多样性和微弱的种群结构,同时表现出与压力和代谢过程相关的特定基因组选择特征,这表明尽管存在高水平的基因流,这些环境仍可能支持适应性反应。

Octavio Paulo, André Henriques, Paulo Sousa, Sara Silva, Davide Galhofa, Luísa Carvalheiro, Thomas Wood, Orianne Rollin2026-10-19
🧬 生物学

Photoperiod alters tissue-specific biochemical organization and trophic quality in the symbiotic jellyfish Phyllorhiza punctata

本研究表明,虽然连续光照在不改变共生水母 *Phyllorhiza punctata* 外部形态的情况下增加了其生物量,但它诱导了组织特异性的生化组成变化,并通过使脂肪酸谱向低多不饱和脂肪酸含量转变,降低了伞盖组织的营养质量。

Sónia Cotrim Marques, Raissa Cerqueira, Sérgio Miguel Leandro, Joana Figueira, Dinis Félix, Marta Neves2026-10-19
🧬 生物学

A Cold-Active GH42 β-Galactosidase from Klebsiella variicola for Aroma- Preserving, Energy-Efficient Processing of Reconstituted Tobacco

本研究表征了一种来自粘质克雷伯氏菌(*Klebsiella variicola*)的新型低温活性 GH42 β-半乳糖苷酶(β-Gal 1527),该酶在 10°C 下应用时能高效水解糖苷结合的前体,从而显著增强复原烟草的风味轮廓,同时提供了一种节能的低温加工替代方案,最大限度地减少了热敏性挥发性化合物的损失。

Lei Xue, Julong Huang, Kaleem Imdad, Shixi Song, Ying Wang, Yonghong Wang, Caiping Chang, Duobin Mao, Shen Huan, Baoan D (…)2026-10-19
🧬 生物学

Single-cell regulatory genomics reveals coordinated myeloid and T-cell reprogramming in liver cirrhosis

本研究利用单细胞调控基因组学,揭示了肝硬化背景下以特定转录因子改变和信号转导偏移为特征的髓系细胞与T细胞状态的协同失调,尽管这些发现仍处于产生假设阶段,尚需进一步验证。

chenxuan li, dedong yuan, qinglei chen, Jiyuan Shi, Li Jin, Zongrui Jin, Deling Wei, Zhong Zeng, Zhuo Cheng, Hanfei Huan (…)2026-10-19
🧬 生物学

Cell phone radiofrequency electromagnetic radiation exposure alters mouse sperm quality and impairs preimplantation development of embryos derived from exposed sperm

本研究表明,小鼠精子在体外短时间暴露于手机射频电磁辐射会通过增加 DNA 碎片化和氧化应激并下调线粒体基因,从而损害精子质量,并最终导致由此产生的植入前胚胎发育延迟及活力降低。

Seyed Abbas Datli Beigi, Mohammad Ali Khalili, Fatemeh Anbari, Bryan J. Woodward, Fatemeh Zare, Behrouz Aflatoonian2026-10-19
🧬 生物学

Extremophile-derived Bacillus licheniformis metabolites selectively remodel macrophage bioenergetics following exposure to Mycobacterium tuberculosis-derived metabolites

本研究表明,极端微生物地衣芽孢杆菌(*Bacillus licheniformis*)产生的次生代谢物通过重塑与自噬及细胞应激管理相关的转录通路,抵消了结核分枝杆菌(*Mycobacterium tuberculosis*)在巨噬细胞中诱导的代谢重编程和呼吸功能障碍。

Kudakwashe Nyambo, Rosette R.F Domtchouang, Hamond Motsi, Ephifania Geza, Brendon Mann, Idah Sithole Niang, Marshall Key (…)2026-10-19