🧬 biology

Extruded blue corn and tepary beans-based tortillas’ impact on obesity and gut microbiota in vivo

这项研究表明,在Wistar大鼠中,由挤压蓝玉米和提帕里豆制成的饼干能改善肠道微生物群多样性并降低总胆固醇,且不会加重血脂异常,为缓解肥胖相关的代谢问题提供了一种潜在的饮食策略。

Guadalupe M. Perez-Guerrero, Cuauhtémoc Reyes-Moreno, Nuria Elizabeth Rocha-Guzmán, Edith Oliva Cuevas-Rodriguez, Mariel (…)2026-06-29
🧬 biology

Identification of Acetylation-Related Gene Biomarkers for Gallbladder Carcinoma via Multi-dataset and Machine Learning, with Insights into Immune Microenvironment Modulation

本研究通过机器学习构建了一个高准确度的诊断模型,鉴定了七个与胆囊癌相关的乙酰化基因生物标志物,并揭示了它们与免疫细胞浸润的显著关联,特别强调了 NCOA1 与激活态自然杀伤细胞之间的联系。

Yecheng Wang, Dongbin Liu, Yaming Zheng, Kuo Liang, Minghao Sui, Xiang Gao2026-06-29
🧬 biology

Microvesicles derived from follicular fluid and seminal plasma modulate human sperm quality after vitrification: Functional and molecular parameters based Assessment

本研究表明,在人类精子玻璃化冷冻培养基中添加高剂量的原始卵泡液或精浆,或低剂量的其衍生的微囊泡,通过增强精子活力、膜完整性和抗氧化能力,同时降低氧化应激和凋亡相关基因的表达,能够显著减轻冷冻损伤。

Morteza Taravat, Mustafa Numan Bucak, Reza Asadpour, Zahra Karimi, Mohammad saber Maroufi, Hojat Ghasemnejad, Tohid Reza (…)2026-06-29
🧬 biology

Retinoic acid controls development and detoxification responses in the mussel Mytilus galloprovincialis despite loss of canonical RAR activity

尽管地中海贻贝(*Mytilus galloprovincialis*)失去了典型的视黄酸受体(RAR)转录激活活性,但外源性视黄酸仍能调节发育并诱导解毒基因表达,这揭示了一种用于管理视黄酸暴露的进化保守机制,该机制独立于传统的 RAR 信号通路运行。

Enrico D'Aniello, Federica Salatiello, Angelica Miglioli, Rosa Maria Vitale, Valeria Tarallo, Giovanna Benvenuto, Samuel (…)2026-06-29
🧬 biology

Breeding of high-yield low-temperature lipase fungi, optimization of fermentation conditions and isolation and purification of lipase

本研究通过诱变和发酵优化,成功培育出一种高产黑曲霉(*Aspergillus niger*)突变株,用以生产一种在15°C下具有卓越催化活性的纯化低温脂肪酶,为节能型工业应用提供了一种具有成本效益的解决方案。

Lutong Yang, Mengai Wang, Hongyan Fu, Yun Zhang, Yu Zhang, Mengni Cui, Bowen Jiang, Hong Chen, Yanwei Cui2026-06-29