234 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This paper presents an improved, open-source LED-based optical autofocus module for light microscopy and a 2D autocorrelation method to quantify its performance, demonstrating that the new system achieves axial stability with a standard deviation of less than 10 nm over 45 minutes despite initial power variations.
This paper demonstrates how a coding agent can formalize and transfer DNA origami design expertise by converting human domain knowledge into repeatable text-file instructions, enabling autonomous execution of complex design pipelines, parametric scaling, and molecular dynamics simulations.
LAS3R is a low-cost, open-source, and secure framework built on a Raspberry Pi hub and ESP32 microcontrollers that enables researchers with minimal technical expertise to rapidly prototype, deploy, and remotely manage multiple custom laboratory automation devices while ensuring robustness and data security.
This study demonstrates that a lysate from FGF2-expressing engineered *Vibrio natriegens* can simultaneously replace both fetal bovine serum and recombinant FGF2 in cell culture media, enabling cost-effective, sustainable, and high-performance cultivation of bovine muscle cells for meat production.
This study establishes *Vibrio natriegens* as a sustainable production platform for L-lysine by engineering feedback-resistant enzymes to achieve high titers from glucose and demonstrating the strain's ability to valorize chitin-derived N-acetylglucosamine.
This study demonstrates that while a muscle-driven simulation framework successfully guided the selection of exotendon designs that reduced energetic cost at high running speeds, the specific parameters predicted to maximize savings did not translate to significant experimental improvements, highlighting the need to account for individual variability when developing assistive running devices.
This study introduces a three-dimensional thermodynamic phase-field framework that successfully models patient-derived tumour spheroid dynamics by quantitatively capturing nutrient-limited growth and mechanical evolution, demonstrating predictive accuracy comparable to established models while uniquely resolving internal mechanical structures not directly observable in experiments.
This paper proposes a minimal nonlinear biomechanical model that utilizes bifurcation theory to explain the variability and sudden deterioration of clinical outcomes in clavicle fractures, offering a theoretical framework for defining safe treatment thresholds and optimizing surgical planning.
This study introduces a novel class of ionizable lipids featuring a sulfur-bearing HHES motif that simultaneously scavenges reactive oxygen species and enables rapid metabolic clearance, thereby decoupling mRNA delivery potency from toxicity and demonstrating safe, effective therapeutic outcomes in both systemic and subretinal applications.
This paper presents a custom device that enables robust light sheet fluorescence microscopy imaging of biological specimens requiring an air-liquid interface, demonstrated through successful applications on mouse salivary glands, human skin cultures, and fruit fly brains.