196 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
TRaP is an open-source, GUI-based Python toolkit that addresses the reproducibility crisis in Raman spectroscopy by providing a unified, declarative framework for transparent, shareable, and deterministic spectral preprocessing across diverse heterogeneous instrument platforms.
This paper presents a one-dimensional computational model demonstrating how a dynamic osteocyte network regulates bone mechanical adaptation through the propagation of biochemical signals, revealing that the discrete addition and removal of osteocytes leads to novel behaviors such as partial recovery after unloading and a stress threshold for resorption, thereby providing a mechanistic basis for Wolff's laws.
This paper presents a robust, low-cost "twisted wire templating" strategy that overcomes existing fabrication limitations to create fully patent, perfusable hydrogel vascular networks seamlessly transitioning from macro- to micro-scales with high fidelity and reduced footprint.
This study demonstrates that implanting soft, porous precision-templated hydrogel scaffolds into the rat brain significantly reduces the foreign body reaction and glial scarring while promoting neurogenesis, offering a promising strategy to improve the efficacy of central nervous system implants.
This study demonstrates that a novel fast-oscillating amplitude-modulated sinusoidal (FAMS) stimulation waveform desynchronizes neural activity in peripheral nerves, resulting in more natural and comfortable sensory perceptions compared to conventional rectangular pulses, thereby offering a promising biomimetic strategy for restoring sensory feedback in amputees.
The paper introduces FOLIC, a novel foveated light-field compound imager that unifies wide-field context and single-cell resolution within a single capture to overcome traditional trade-offs in spatial resolution, field of view, and depth perception for biomedical applications.
This systematic review and meta-analysis of 28 in vivo animal studies demonstrates that experimental intervertebral disc injury consistently leads to mechanical and morphological deterioration, identifying Young's modulus as a sensitive indicator of functional degeneration while highlighting the need for methodological standardization to improve clinical translation.
The paper introduces Apollo-IRE1, a genetically encoded, ratiometric fluorescent sensor that enables live-cell, multiplexed imaging of ER stress dynamics by detecting IRE1 oligomerization through fluorescence anisotropy, offering a robust tool for studying beta-cell dysfunction in diabetes.
This study demonstrates that elastin-like recombinamer (ELR)-gelatin hydrogels with imprinted micro- and nano-gratings significantly accelerate endothelial monolayer formation by synergizing bioactive matrix chemistry with surface topography to enhance early cell capture and promote rapid, stable alignment.
This study enhances the efficacy and safety of genetically delivered TGF-β monomers for cancer immunotherapy and fibrosis treatment by incorporating a modified pro-domain to correct folding issues and fusing a CD44-binding domain to achieve over 30-fold increased inhibitory activity on target cells.