354 papers
This study of university dining hall patrons reveals that animal-based meatballs significantly outperform plant-based alternatives in key sensory attributes like moistness, meatiness, and tastiness, suggesting that achieving sensory parity rather than emphasizing sustainability is crucial for increasing plant-based meat acceptance in institutional settings.
Drug-free PLGA nanoparticles promote comparable locomotor recovery in both male and female mice after spinal cord injury by engaging distinct, sex-specific immune mechanisms—reducing macrophage infiltration in females via splenic accumulation and attenuating microglial activation in males via lesion accumulation—to ultimately converge on reduced scarring and enhanced remyelination.
This study demonstrates that human induced pluripotent stem cell-derived neurospheroids, particularly when engineered with specific cellular heterogeneity and modular spatial organization, successfully recapitulate key features of in vivo cortical complexity and brain-like network dynamics.
This study presents a nanoscale mineralized bone-on-a-chip model that autonomously recapitulates endogenous osteocyte-osteoclast signaling to drive bone remodeling, predict drug responses, and mimic cancer invasion without requiring exogenous growth factors.
This paper presents a lightweight, wireless photoacoustic neuromodulation patch utilizing a spherical double logarithmic spiral array of CNT/PDMS emitters to achieve robust, geometry-encoded acoustic focusing for precise deep-brain stimulation without the need for bulky electronics or complex phase control.
This study presents the development of a safer and more potent therapeutic for advanced prostate cancer by engineering human-derived PSMA-targeted CAR T cells with membrane-bound IL-12, which demonstrated enhanced T cell expansion, cytokine production, and potent anti-tumor efficacy in both in vitro and in vivo bone-metastatic models.
This study presents HiCaRI, a first-generation, single-fluorophore genetically encoded calcium indicator derived from the highly photostable protein StayGold, which demonstrates a large inverse fluorescence response and improved brightness and photostability compared to previous GFP-based indicators.
This study demonstrates that label-free optical metabolic imaging (OMI) using autofluorescence lifetime imaging can non-destructively resolve metabolic heterogeneity to accurately identify immune cell subtypes and activation states within heterogeneous peripheral blood mononuclear cell (PBMC) cultures, offering a promising tool for improved disease diagnostics and cell therapy development.
This study presents an IgG-inspired, multivalent DNA nanostructure ("nano-synbody") that achieves high-affinity, tunable, and reversible binding to SARS-CoV-2 spike proteins by matching the target's geometry and valency, effectively neutralizing both wild-type and Omicron variants while demonstrating programmable assembly and disassembly.
The authors present PHIROS, a microfluidic platform that enables long-term, high-resolution imaging and controlled perturbations of organotypic brain slices, thereby facilitating detailed mechanistic studies of cell interactions and tumor behavior within a physiologically relevant tissue context.
This study demonstrates that an integrated bioelectronic iontophoresis device delivers fluoxetine to porcine wounds more effectively than topical bolus dosing, achieving higher local tissue concentrations and sustained antibacterial levels without systemic absorption or adverse effects.
This paper presents a generalizable two-component strategy that engineers the safety of the highly toxic antibiotic calicheamicin by combining a conditionally-active conjugate with a co-administered antidote enzyme, thereby enabling the clinical use of potent but previously inaccessible antimicrobial compounds while maintaining efficacy and minimizing host toxicity.
This study presents a modular co-culture system combining engineered *Acinetobacter baylyi* and *Escherichia coli* strains to overcome metabolic bottlenecks and efficiently convert lignin-derived p-coumaric acid into cis,cis-muconic acid with high carbon yield.
This study demonstrates that programmable tetrahedral DNA nanostructures can actively deliver biomolecules into pollen tubes to modulate their growth via actin reorganization and ROS modulation while preserving reproductive fitness, thereby establishing a novel platform for targeted plant reproductive engineering.
This study presents a 3D anisotropic hydrogel-electromagnetic biohybrid system that synergistically combines soft microfilaments with wireless electrical stimulation to non-invasively guide neural morphogenesis, promoting healthy neurite extension and functional recovery in both central and peripheral nervous system models.
This paper introduces TurboPRANCE, an open-source, robotic platform integrating approximately 200 independently controlled turbidostats with 96 parallel PACE lagoons and Nanopore sequencing to enable high-throughput, autonomous, and multivariate continuous evolution at an unprecedented scale.
This study demonstrates that pre-activating integrins on monocyte-mimetic nanoparticles significantly enhances their specific binding to inflamed endothelial cells and accumulation in atherosclerotic lesions without compromising safety or stability, thereby improving the therapeutic targeting potential of this biomimetic nanomedicine platform.
The paper introduces and validates FLOATES, a minimally invasive technique using an untethered floating wire implanted in the brain to relay transcranial currents, thereby enabling precise and efficient deep brain stimulation with significantly lower motor thresholds than conventional methods.
By integrating an evolutionary genetic algorithm with AI-driven structural design, researchers successfully overcame the challenges of targeting Nectin-4 to rapidly generate highly potent, stable minibinders that function effectively as cancer detection reagents and T cell engagers.
This study leverages generative AI to expand upon a previously identified cortisol-binding peptide, successfully screening a library of nearly 10,000 sequences to discover high-affinity candidates for non-invasive stress detection.