354 papers
This study demonstrates that mineralized collagen scaffolds facilitate reciprocal crosstalk between macrophages and mesenchymal stem cells, where early-stage inflammatory interactions enhance MSC immunomodulatory activity and drive subsequent M2-like macrophage polarization and osteogenic differentiation to promote bone regeneration.
This paper presents a self-terminating bilayer hydrogel actuator fabricated via 3D bioprinting that autonomously grips and releases intestinal tissue by coupling rapid thermoresponsive closure with slower enzyme-mediated mechanical softening, enabling localized enzyme delivery without external intervention.
This study demonstrates that the pore architecture and glycosaminoglycan composition of mineralized collagen scaffolds intrinsically guide human macrophages toward pro-regenerative M2 phenotypes, with specific structural and chemical features modulating the kinetics and intensity of this anti-inflammatory response to enhance craniomaxillofacial bone repair.
This paper presents and validates a robust, label-free Digital Holographic Microscopy pipeline capable of accurately estimating cell viability across diverse industrial bioproduction conditions without requiring calibration, while also offering early detection of viability decline and correlation with protein titer.
The paper introduces Consistent Reference External Batch (CREB) harmonization, a novel extension of ComBat that learns site effect priors exclusively from training data to enable leakage-free, deployable harmonization of unseen external fMRI datasets while preserving biological variance and maintaining performance comparable to traditional methods.
This study characterizes peptide-induced extracellular vesicles in *E. coli* as a distinct, high-yield platform that enables the efficient production and purification of concentrated, correctly folded recombinant proteins with superior purity compared to endogenous outer membrane vesicles.
This study demonstrates that a novel hydrogel derived from decellularized human adipose tissue (atdECM) provides a physiologically relevant, tissue-specific microenvironment that supports the generation of human pancreatic organoids with improved homeostatic transcriptional profiles compared to the standard Matrigel matrix.
This study identifies reduced effective diffusion and nonspecific adsorption as the primary causes of amplification lag in paper-based LAMP assays and demonstrates that BSA pre-coating effectively mitigates these barriers, significantly accelerating detection across a wide range of template concentrations.
This paper introduces a teacher-student deep learning framework that generates white matter tractography from FLAIR images by leveraging knowledge distilled from diffusion MRI, demonstrating that tractography patterns may reflect a shared latent structural space rather than being unique to diffusion-specific imaging.
This study develops a novel GAT1508-PEGylated gold nanoparticle probe that specifically targets and detects ER+ breast cancer cells by binding to overexpressed GIRK1 ion channels, leveraging a combination of small-molecule drug design, electrophysiology, and nanotechnology to enable optical screening without fluorescent labels.
This study demonstrates that pubertal development in female pigs alters the anterior cruciate ligament's molecular profile and histology, specifically increasing estrogen receptor alpha expression in post-pubescent tissues, which suggests an age-dependent shift in hormonal sensitivity that may contribute to the higher risk of ACL injuries in adolescent female athletes.
This paper proposes a modified inverted pendulum model incorporating hip torque and muscle intervention to demonstrate that human walking mechanics and preferred speed are governed by the interplay of step length, speed, and work capacity constraints rather than energetic optimality alone.
This study demonstrates that the morphology of the vertical ground reaction force during human walking, particularly the timing of its mid-stance trough, is directly determined by the mechanical energy imbalance between push-off and collision impulses during the step-to-step transition.
This study introduces a synthetic immunological niche scaffold that captures stage-specific immune dysregulation in Type 1 Diabetes, enabling the identification of an early gene signature that distinguishes disease progressors and predicts therapeutic response to anti-TNF-α treatment.
This study validates a novel, non-invasive in-ear AURIS sensor utilizing a PDMS substrate for monitoring heart rate variability during spinal cord neuromodulation, demonstrating gold-standard fidelity comparable to conventional chest electrodes and establishing a robust foundation for closed-loop bioelectronic medicine.
The authors present MeNet-AO, a rapid, guide-star-free adaptive optics method utilizing a physics-informed multi-encoder network to correct deep-tissue optical aberrations, thereby enabling high-resolution, dynamic subcellular imaging in living organisms.
This paper introduces a modular, magnetically interfaced impedance-sensing system for microphysiological models that enables real-time, continuous assessment of barrier integrity while maintaining compatibility with standard open-well laboratory workflows and diverse experimental conditions.
This paper presents an AI-driven framework that decouples mRNA sequence design from manufacturing by training a deep learning model on a million sequences to predict and optimize manufacturability, resulting in over 7.5-fold yield improvements and establishing a universal design paradigm to accelerate mRNA therapeutics development.
The authors present ThermiQuant VitroMini, a dual-sided, optically transparent solid-state heater that ensures precise isothermal conditions for quantitative colorimetric LAMP assays on paper-based microfluidic devices across varying ambient temperatures, thereby enabling portable and reproducible molecular diagnostics.
This study demonstrates that tendon functional adaptation to increased tensile loading is driven by an anabolic remodeling program involving TGF-β and IL-6 signaling, enhanced collagen alignment, and suppressed proteolysis, whereas mechanical unloading induces a catabolic phenotype characterized by reduced synthesis and matrix breakdown.