📄 Category

bioengineering

280 papers

Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.

At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.

📄 bioengineering

Epigenetic Regulation of Stable SARS-CoV-2 RBD-sfGFP Expression in Primary Human Splenic Fibroblasts

This study demonstrates that immortalized human splenic fibroblasts can stably express SARS-CoV-2 RBD-sfGFP for over three months, validating them as a viable platform for recombinant protein production while revealing that expression stability is maintained through oscillatory dynamics rather than progressive silencing, albeit with increasing inter-cellular heterogeneity over time.

Maan, K. S., Baloch, Z. A., Bhullar, S. S., Vashishat, I., Assogba, B. D.2026-07-23
📄 bioengineering

Texture Profile Analysis and Consumer Sensory Evaluation of Plant-Based and Conventional Breaded Shrimp

Despite plant-based breaded shrimp exhibiting significantly higher instrumental hardness, stiffness, and chewiness than conventional shrimp, consumer sensory evaluation revealed no significant differences in hedonic ratings or purchase intent, suggesting that the breaded format effectively masks these textural disparities and that achieving instrumental texture parity is not essential for consumer acceptance.

Koosis, A. O., Kuhl, E.2026-07-20
📄 bioengineering

Dynamic, single-cell monitoring of CAR T cell identity and activation with Raman spectroscopy

This study introduces a label-free, single-cell monitoring approach combining surface-enhanced Raman spectroscopy and machine learning to dynamically track both the identity and activation states of CAR T cells across donor-derived models and clinical patient samples, offering a rapid, point-of-care alternative to current static phenotyping methods.

Stiber, A., Quach, B., Ogunlade, B., Georgiadis, A., Chang, K., Li, Y., Quinn, P., Wang, H., Tsui, K. C. Y., Ang, C., So (…)2026-07-18
📄 bioengineering

golgi: an open-source graphical platform for image-to-recruitment modeling of peripheral nerve stimulation

The paper introduces **golgi**, an open-source, graphical platform that democratizes peripheral nerve stimulation modeling by integrating the entire workflow from anatomical imaging to fiber recruitment prediction, thereby enabling researchers and clinicians to achieve anatomically realistic, verifiable, and reproducible in-silico studies without requiring specialized coding expertise.

Lung, D., Jia, Y., Blumer, R., Reissig, L., Zopf, L. M., Heimel, P., Kraus, C., Moro, A., Fachino, M., Haberbusch, M.2026-07-13
📄 bioengineering

Chemical Boosting of Foldase Condensates Accelerates Oxidative Protein Folding

This study demonstrates that chemically targeting the active site of protein disulfide isomerase A6 (PDIA6) with a small molecule (pMePySH) significantly amplifies the catalytic efficiency of PDIA6 condensates, thereby accelerating oxidative protein folding and promoting insulin secretion both in vitro and in cellular environments.

Watabe, M., Kuramochi, T., Fukushima, M., Kinoshita, M., Akiba, H., Ban, K., Hashimoto, M., Uchida, N., Kenta Arai, K. A (…)2026-07-10
📄 bioengineering

Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states

This study demonstrates that device-embedded accelerometry provides a more robust and accurate biomarker for tracking Parkinsonian motor states across varying stimulation conditions compared to neural signals, supporting its integration into next-generation adaptive deep brain stimulation systems.

LIU, T., Yao, J., Abdi-Sargezeh, B., Sharma, A., Lasbareilles, C., Tsi Lok Ho, R., Cheung, J., Denison, T., Tan, H., Neu (…)2026-07-09
📄 bioengineering

Spectral characterisation of short-wave infrared (SWIR) tissue chromophores and tissue-mimicking phantom optical properties

This study characterizes the optical properties of key tissue chromophores and tissue-mimicking phantoms across visible to short-wave infrared (SWIR) wavelengths, providing a consistent dataset integrated into an open-source toolkit to facilitate the design and simulation of next-generation SWIR spectroscopy and imaging technologies.

Watt, M. J., Malouf, L., Tao, R., Racicot, I., Else, T. R., Groehl, J., Bohndiek, S. E.2026-07-07