196 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This study introduces a novel class of ionizable lipids featuring a sulfur-bearing HHES motif that simultaneously scavenges reactive oxygen species and enables rapid metabolic clearance, thereby decoupling mRNA delivery potency from toxicity and demonstrating safe, effective therapeutic outcomes in both systemic and subretinal applications.
This paper presents a custom device that enables robust light sheet fluorescence microscopy imaging of biological specimens requiring an air-liquid interface, demonstrated through successful applications on mouse salivary glands, human skin cultures, and fruit fly brains.
This study introduces a microfluidic platform that enables the co-development of distinct dorsal and ventral forebrain identities within a single, continuous organoid by delivering localized Sonic hedgehog signaling, thereby offering a scalable alternative to organoid fusion for studying brain regionalization.
This paper presents an improved 1300-nm three-photon microscope that enables high-resolution structural and functional imaging of the intact mouse brain at depths up to 2.5 mm and 2 mm, respectively, thereby accessing deep brain regions previously unreachable by multiphoton imaging.
This study characterizes the mechanical, rheological, and sensory properties of minimally processed lion's mane mushroom steak, demonstrating its favorable meat-like texture and establishing a significant inverse correlation between its measured physical stiffness and perceived softness to support its development as a whole-cut alternative protein.
This study develops a biodegradable PLGA/PCL membrane-based lung alveoli-on-a-chip that mimics the dynamic structural evolution of the lung interface to effectively model diesel particulate matter-induced injury and evaluate therapeutic interventions.
This study presents a biodegradable, self-remodeling lung alveoli-on-a-chip that accurately mimics the human air-blood interface to effectively assess the oxidative and genotoxic pulmonary toxicity of various waste-combustion-derived particulates, revealing rubber combustion particles as the most hazardous.
This paper proposes a decoupled two-step framework that combines a YOLO-based detector with a specialized DenseNet121 ensemble classifier to achieve high-accuracy detection and fine-grained morphological classification of sickle red blood cells in full-scope microscopy, significantly outperforming single-step models especially for minority phenotypes.
This paper demonstrates that standard CTC-trained neural decoders in brain-to-text BCIs produce over-confident predictions, and proposes a two-stage cross-entropy training approach that generates calibrated, informative uncertainty to serve as an active control signal for safer and more effective probabilistic co-control.
This study demonstrates that engineering *Escherichia coli* with three coordinated pathways for sulfide generation, cadmium uptake, and nucleation enables the controlled biogenic synthesis of CdS quantum dots, where the specific combination of pathways dictates nanoparticle yield and size even under low cadmium concentrations.