234 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This paper presents a real-time, automated deep learning workflow integrated with a microfluidic platform and standard inverted microscope that enables non-invasive, high-magnification longitudinal imaging of freely moving *C. elegans*, overcoming traditional challenges of motion blur and target loss without compromising natural physiology.
The study demonstrates that Kubu, a thermostable PETase from *Kutzneria buriramensis*, achieves near-complete enzymatic depolymerization of commercial PLA/PBAT blend mulch films within 24 hours without pretreatment, offering a cost-effective single-enzyme solution for managing agricultural plastic waste.
This study demonstrates that integrating dense, family-specific experimental screening with targeted, sequence-based deep learning creates a data-efficient discovery strategy that significantly outperforms generalist foundation models in identifying high-performing enzyme variants while providing mechanistic insights into structure-function relationships.
This study introduces NANITE, a nonviral strategy that amplifies in vivo genome editing by programming transfected cells to produce and transfer editing enzymes via lipid vesicles to neighboring cells, thereby significantly boosting therapeutic efficiency in both cultured cells and mouse models.
The paper introduces OCDesign, an objective curriculum-guided framework that sequentially introduces design objectives (such as solubility, stability, and binding affinity) to successfully engineer multi-property proteins with fewer experimental iterations than traditional one-shot optimization methods.
This study demonstrates that nanostructured zirconia thin films serve as active neurogliomorphic interfaces that selectively enhance glial calcium signaling and modulate neuron-glia communication in both central and peripheral nervous system cultures, paving the way for advanced biohybrid neural interfaces.
This study demonstrates that BMSC-laden PEGDA/HAMA dual-crosslinked hydrogels with higher stiffness promote osteochondral defect filling and subchondral bone remodeling in rats, although the resulting repair tissue remains predominantly fibrocartilaginous rather than hyaline-like.
This study introduces and validates 4D Oxy-wavelet MRI as a novel, non-invasive, high-resolution imaging technique capable of spatially mapping mitochondrial electron transport chain function across the lifespan in both animal models and humans by analyzing oxygen homeostasis responses to hypoxic challenges.
This study establishes *Synechococcus* sp. PCC 11901 as a secretion-competent chassis for photosynthetic biomanufacturing by systematically evaluating signal peptides, revealing that while the Tat pathway leader FutA outperforms Sec candidates for eYFP, optimal signal peptide selection is cargo-dependent, as evidenced by the superior performance of the thermitase Sec signal for lichenase secretion.
This pilot study demonstrates that a multi-domain signal processing framework applied to portable electroretinogram (ERG) recordings can effectively identify novel retinal temporal dysfunction biomarkers, achieving 85.8% accuracy in distinguishing Alzheimer's disease patients from controls and supporting the potential of portable ERG devices for early, non-invasive AD detection.