234 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
BoltzGen is a unified, all-atom generative model that integrates structure prediction with flexible design constraints to successfully generate functional protein and peptide binders for a diverse range of biomolecular targets, as validated across eight experimental campaigns.
This study demonstrates that granular hydrogel composites (GHCs) filled with fibrin and collagen enable rapid, pre-culture-free revascularization of embedded endothelial cells and successfully restore blood flow to human ovarian tissue grafts within 10 days of implantation, offering a promising platform for enhancing the survival of engineered tissue transplants.
This study developed a bi-level inverse optimal control framework that successfully reproduces postoperative squat kinematics in total knee replacement patients using either subject-specific or group-level cost functions, offering a promising foundation for future preoperative prediction of how implant alignment affects dynamic functional outcomes.
This study optimizes the growth conditions and post-processing methods for kombucha-derived cellulose non-wovens to achieve superior mechanical properties via lyophilization, while demonstrating a circular lifecycle through enzymatic degradation and electrospinning-based re-manufacturing.
This paper introduces DOCS, a combinatorial DNA origami platform that encodes information into scaffold molecules to achieve biologically replicable, thermostable, and randomly accessible data storage and molecular authentication, bridging the gap between classical sequence-based storage and DNA nanostructure methods.
This study demonstrates that multiplex-engineered rhesus macaque NK cells, modified to express CAR, CXCR5, IL-15, PD-1 knockout, and transient CCR7, are safe, expandable, and effectively home to SIV viral reservoirs within B cell follicles of lymphatic tissues, offering a promising strategy for HIV cure development.
This study advances Xolography for tissue engineering by developing a refractive index-matched bioink using iodixanol that enables high-resolution, volumetric printing of cell-dense (up to 5×10⁶ cells/mL) constructs with complex geometries and functional skeletal muscle tissue formation, while navigating the critical trade-off between optical transparency and photochemical reactivity.
This paper introduces ProtGPT3, an open-source family of promptable and aligned protein language models that demonstrates few-shot prompting and inference-time steering as scalable, effective alternatives to fine-tuning for generating functional and diverse protein sequences.
This study presents a spatially engineered hydrogel platform utilizing controlled morphogen exposure and digital light processing to direct the formation of posterior organizers in cerebral organoids, thereby enabling precise spatial patterning that more faithfully recapitulates native tissue organization.
This study proposes a computationally efficient pseudo-3D stochastic growth model based on Markov processes to simulate vascular plaque dynamics and derive optimal dosing curves for targeted drug delivery, overcoming the prohibitive costs of traditional 3D CFD while enabling personalized medicine strategies.