354 papers
This study introduces a new family of poly(acrylamido) lipid-based PEG alternatives that significantly enhance mRNA-LNP transfection efficacy in immune cells and lymphoid tissues while successfully evading anti-PEG antibodies to restore therapeutic effectiveness during repeated dosing.
This paper presents a robust, accessible, and reproducible fabrication and quality control workflow for producing elastic porous PDMS membranes using standard equipment, thereby overcoming existing limitations in organ-on-a-chip device manufacturing.
This study utilizes fMRI and biophysical modeling to demonstrate that transcranial photobiomodulation elicits dose-dependent, widespread neurovascular responses in the human brain that are influenced by stimulation parameters and biological factors, thereby establishing a critical foundation for precision medicine in brain stimulation.
This study utilizes ProteinMPNN and LigandMPNN to redesign the PET hydrolase PHL7, successfully generating variants (notably D5) that achieve high depolymerization activity at 50°C with improved expression and stability, thereby enabling efficient plastic recycling and potential virgin PET resynthesis under mild, energy-efficient conditions.
This study demonstrates that static uniaxial mechanical stretch induces density-dependent collective alignment of C2C12 myoblasts, where self-generated cellular forces drive initial orientation exploration and strong intercellular interactions in dense cultures provide the thermodynamic bias necessary to sustain and reinforce alignment.
This paper introduces Sliding-Window Prediction Correlation (SWpC), a novel method for estimating time-varying directed functional connectivity that overcomes the limitations of traditional undirected approaches, and validates its superior sensitivity and biological interpretability across multimodal neuroimaging data and clinical applications such as post-concussion vestibular dysfunction.
The paper introduces FLIP2, an expanded protein fitness benchmark featuring seven new datasets and real-world engineering splits that reveal simpler models often outperform fine-tuned protein language models in generalizing across diverse data distributions.
This study reveals that near-neutral pH conditions in biological environments induce silica nanoshell hydrolysis and nanoparticle aggregation in gold nanostar-silica conjugates, leading to significant and variable SERRS signal enhancement that contrasts with the stability observed in acidic lysosomal conditions.
This study demonstrates the successful integration of heat-shock-tolerant *Bacillus subtilis* spores into three thermoplastic polyesters (PCL, PLA, and PBAT) via hot melt extrusion, resulting in biocomposites that exhibit significantly enhanced toughness and programmable, accelerated disintegration in composting environments while remaining suitable for 3D printing.
This study demonstrates that chronological aging in mouse mesenchymal stem cells impairs differentiation potential, alters mitochondrial morphology and gene expression, and compromises the cells' ability to mechanically respond to low-intensity vibration stress.
This study demonstrates that liquid crystal polymer (LCP) is a viable, long-term moisture barrier for implantable medical electronics, showing stable performance and no delamination over an accelerated aging period equivalent to at least 8.1 years of in vivo use.
This study demonstrates that boiling ginger extracellular vesicles to create thermally reassembled nanoparticles (B-GEVs) enhances their surface composition for improved intestinal targeting and cellular uptake, enabling a synergistic oral therapy for colitis when loaded with TNF- siRNA.
This study introduces a non-genetic, microfluidic mechanical compression platform (-CPR) that effectively rejuvenates aged stem cells by applying controlled hydrodynamic deformation to reduce senescence markers, restore stemness and structural integrity, and enhance therapeutic efficacy without compromising their fundamental biological properties.
This paper presents an injectable, retrievable "soft implant" composed of surface-eroding poly(orthoester) microparticles within a hydrogel that achieves long-term, zero-order release of therapeutics for over six months, offering a transformative solution for improving patient adherence in treatments requiring sustained dosing.
This study demonstrates that a single deep-learning pipeline, utilizing a standardized preprocessing framework and an anatomically informed cross-species montage, can achieve robust three-state sleep staging in both humans and rodents and successfully transfer a model trained exclusively on rodent data to human EEG recordings without any retraining.
This study demonstrates that the volumetric morphological state of cancer-associated fibroblasts (CAFs) within tunable 3D hydrogels serves as a critical mechanotransduction intermediate, where stiff matrices constrain CAF geometry to drive chemoresistance in breast cancer, contrasting with the distinct stress responses observed in soft matrices and 2D cultures.
This study leverages large-scale CRISPRi datasets to develop an updated scoring scheme and characterize off-target effects, culminating in the design and validation of the optimized, compact Cas9 CRISPRi library named Katsano.
This study demonstrates that large-scale AI analysis of language, speech, and movement in clinical interviews can effectively disentangle the overlapping symptoms of Autism and ADHD by identifying distinct behavioral signatures, such as narrative divergence and vocal pitch for Autism versus specific motor hyperactivity for ADHD.
This study developed lactoferrin-functionalized red blood cell membrane nanoparticles loaded with resmetirom, which demonstrated enhanced hepatocyte targeting and significantly reduced lipid accumulation in an in vitro model of metabolic dysfunction-associated steatotic liver disease (MASLD).
This study presents a novel, biocompatible, mannose-functionalized lipid nanoparticle platform that efficiently delivers anti-inflammatory miR-146a to macrophages with enhanced endosomal escape and favorable in vivo biodistribution, offering a promising therapeutic strategy for treating macrophage-driven inflammatory disorders.