196 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This paper presents and validates a robust, label-free Digital Holographic Microscopy pipeline capable of accurately estimating cell viability across diverse industrial bioproduction conditions without requiring calibration, while also offering early detection of viability decline and correlation with protein titer.
This study characterizes peptide-induced extracellular vesicles in *E. coli* as a distinct, high-yield platform that enables the efficient production and purification of concentrated, correctly folded recombinant proteins with superior purity compared to endogenous outer membrane vesicles.
This paper introduces a teacher-student deep learning framework that generates white matter tractography from FLAIR images by leveraging knowledge distilled from diffusion MRI, demonstrating that tractography patterns may reflect a shared latent structural space rather than being unique to diffusion-specific imaging.
This study demonstrates that pubertal development in female pigs alters the anterior cruciate ligament's molecular profile and histology, specifically increasing estrogen receptor alpha expression in post-pubescent tissues, which suggests an age-dependent shift in hormonal sensitivity that may contribute to the higher risk of ACL injuries in adolescent female athletes.
This study introduces a synthetic immunological niche scaffold that captures stage-specific immune dysregulation in Type 1 Diabetes, enabling the identification of an early gene signature that distinguishes disease progressors and predicts therapeutic response to anti-TNF-α treatment.
This study validates a novel, non-invasive in-ear AURIS sensor utilizing a PDMS substrate for monitoring heart rate variability during spinal cord neuromodulation, demonstrating gold-standard fidelity comparable to conventional chest electrodes and establishing a robust foundation for closed-loop bioelectronic medicine.
This study of university dining hall patrons reveals that animal-based meatballs significantly outperform plant-based alternatives in key sensory attributes like moistness, meatiness, and tastiness, suggesting that achieving sensory parity rather than emphasizing sustainability is crucial for increasing plant-based meat acceptance in institutional settings.
This study demonstrates that label-free optical metabolic imaging (OMI) using autofluorescence lifetime imaging can non-destructively resolve metabolic heterogeneity to accurately identify immune cell subtypes and activation states within heterogeneous peripheral blood mononuclear cell (PBMC) cultures, offering a promising tool for improved disease diagnostics and cell therapy development.
This study utilizes cryo-electron microscopy to reveal that kinetically enhanced ribosomes evolved via oRibo-PACE achieve elevated translation rates through specific 16S rRNA mutations that introduce localized structural destabilization and RNA-protein rearrangements, rather than altering conserved catalytic centers.
This study demonstrates that fusing CRISPR-Csm complexes with the RNA ligase RtcB enables programmable RNA excision and the creation of chimeric transcripts ("spligation") in living cells, offering a novel method for precise RNA manipulation independent of canonical splice sites.