354 papers
By utilizing a novel integrated biomechanical bioreactor, this study reveals that fibroblast tensional homeostasis is a dynamic balance between cellular contractility and extracellular matrix densification rather than a constant stress state, with excessive matrix density ultimately disrupting this equilibrium to trigger pro-survival signaling.
This study demonstrates that optogenetically activating WNT signaling in a subset of human pluripotent stem cells within a mixed aggregate drives self-organization into distinct germ layers via non-autonomous TGF{beta}/BMP induction, providing a robust in vitro model that recapitulates key mechanisms of human gastrulation.
This paper presents a simple, enzyme-free, and amplification-free quantitative DNA detection method using YVO4:Eu luminescent nanoparticles that achieves high sensitivity (50 aM) for SARS-CoV-2 targets, offering a portable and cost-effective alternative to traditional qPCR for infectious disease diagnosis.
This study investigates the biomineralization of chicken eggshells, identifying hydroxyapatite in the cuticle and proposing that shell thickening in the vertical and palisade layers occurs via an additive mechanism where nanodroplets containing mineral, water, and organic components progressively deposit to form lamellae, transforming calcium phosphate nanospheres into calcium carbonate nanofibers.
This study demonstrates that RNA interference (RNAi) targeting key metabolic genes in the whitefly *Bemisia tabaci* significantly reduces its population and induces high mortality in transgenic cassava, offering a promising long-term solution to control the vector of devastating cassava diseases in East Africa.
This study combines human experiments and modeling to demonstrate that while the Virtual Pivot Point strategy and trunk dynamics effectively manage stability and energy on gentle slopes, humans recruit a multi-joint knee and ankle strategy to navigate steeper terrain, offering critical insights for exoskeleton design.
This study demonstrates the development and efficacy of biodegradable magnesium-PGS intra-arterial devices capable of sustained, focal drug delivery to target organs like the kidney and brain, achieving significantly higher local drug concentrations with reduced systemic toxicity compared to oral administration.
This paper introduces flex-ISMS, a flexible thin-film intraspinal microstimulation array that overcomes the limitations of existing microwire technologies by demonstrating high spatial selectivity, minimal tissue displacement, and the ability to evoke graded, near-natural motor responses in an acute pig model, thereby establishing a viable foundation for restoring motor function after spinal cord injury.
This study demonstrates that rational modification of the -strand length within the CsgA -solenoid core, guided by computational modeling, unlocks a new axis of structural plasticity that enables the programmable design of engineered living materials with tunable mechanical properties.
This study demonstrates that microbubble-enhanced focused ultrasound significantly improves the targeted delivery of systemically administered adeno-associated virus vectors to brain tumors, resulting in quantifiable increases in vector accumulation and transgene expression as validated by non-invasive PET imaging.
This study presents a robust photoelectrochemical biosensing platform that integrates clamp-inhibited loop-mediated isothermal amplification with enzyme-free singlet oxygen transduction to achieve highly selective and sensitive detection of KRAS mutations in complex wild-type backgrounds, demonstrating clinical utility through validation in cell lines and patient tissues.
This study presents an inverse engineering framework that integrates sensitivity analysis, genetic algorithm optimization, and similarity mapping to decode biological dynamics, enabling the rapid identification of adaptive crop strategies and bridging the gap between computational optima and field-validated cultivars without relying on decade-long empirical cycles.
This study introduces an evolutionary selection strategy that iteratively screens large libraries of DNA nanostructures against mammalian cells to identify and validate specific structural designs with enhanced, cell-type-specific internalization capabilities for targeted drug delivery.
This study demonstrates that Magnetic Particle Imaging (MPI) enables rapid, zero-background, and quantitative whole-body tracking of magnetically labeled stem cells in vivo, revealing dynamic differences in organ accumulation and clearance based on cell type and injection route.
This paper introduces AbNatiV2 and its paired variant p-AbNatiV2, deep learning models trained on millions of sequences to significantly improve the assessment of nativeness and pairing likelihood for both nanobodies and conventional antibodies, thereby supporting more effective design and humanization strategies.
This paper reports the first successful direct in vivo MRI of collagen by utilizing microsecond-scale imaging and echo subtraction to overcome the protein's previously undetectable short resonance lifetimes.
This study characterizes distinct spectral and phase-amplitude coupling patterns in the Globus Pallidus internus across locomotor states in Parkinson's disease, revealing that specific neural modulations correlate with clinical motor scores and freezing-of-gait while demonstrating an inverse relationship to subthalamic nucleus activity.
This study demonstrates that photo-clickable decellularized small intestine submucosa-norbornene (dSIS-NB) hydrogels with tunable stiffness (~2.5 kPa) serve as an effective, tumor-free Matrigel alternative for generating functional, highly pure human iPSC-derived pancreatic ductal organoids, whereas softer gels and Matrigel fail to support proper ductal differentiation.
This study demonstrates that label-free Raman imaging combined with multivariate analysis can identify distinct molecular signatures in human skin, specifically revealing a beta-sheet-enriched keratin component (C5) localized to basal stem cell niches as a potential biomarker for evaluating stem cell localization and differentiation.
This study optimized the Zebrafish Embryo Genotyper (ZEG) automated system by refining chip design and operational parameters, achieving over 95% DNA collection sensitivity and embryo survival while increasing DNA yield by more than 50% without adverse effects on development.