196 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This study introduces a new family of poly(acrylamido) lipid-based PEG alternatives that significantly enhance mRNA-LNP transfection efficacy in immune cells and lymphoid tissues while successfully evading anti-PEG antibodies to restore therapeutic effectiveness during repeated dosing.
This study demonstrates that removing IgA and IgM via anion-exchange chromatography significantly enhances the efficiency and throughput of 20-nm nanofiltration for caprylic acid-purified IgG, offering a robust and scalable virus safety solution for plasma-derived immunoglobulin production in resource-limited settings.
The paper introduces FLIP2, an expanded protein fitness benchmark featuring seven new datasets and real-world engineering splits that reveal simpler models often outperform fine-tuned protein language models in generalizing across diverse data distributions.
This study demonstrates that boiling ginger extracellular vesicles to create thermally reassembled nanoparticles (B-GEVs) enhances their surface composition for improved intestinal targeting and cellular uptake, enabling a synergistic oral therapy for colitis when loaded with TNF- siRNA.
This paper presents an injectable, retrievable "soft implant" composed of surface-eroding poly(orthoester) microparticles within a hydrogel that achieves long-term, zero-order release of therapeutics for over six months, offering a transformative solution for improving patient adherence in treatments requiring sustained dosing.
This study demonstrates that a single deep-learning pipeline, utilizing a standardized preprocessing framework and an anatomically informed cross-species montage, can achieve robust three-state sleep staging in both humans and rodents and successfully transfer a model trained exclusively on rodent data to human EEG recordings without any retraining.
This study demonstrates that large-scale AI analysis of language, speech, and movement in clinical interviews can effectively disentangle the overlapping symptoms of Autism and ADHD by identifying distinct behavioral signatures, such as narrative divergence and vocal pitch for Autism versus specific motor hyperactivity for ADHD.
This study demonstrates that optogenetically activating WNT signaling in a subset of human pluripotent stem cells within a mixed aggregate drives self-organization into distinct germ layers via non-autonomous TGF{beta}/BMP induction, providing a robust in vitro model that recapitulates key mechanisms of human gastrulation.
This study reveals that residual polarization ellipticity in waveplate-compensated polarization-resolved second harmonic generation microscopy, which persists despite optimal compensation, likely stems from the interaction between the broad spectral bandwidth of femtosecond lasers and wavelength-dependent birefringence in optical elements, thereby limiting the accuracy of quantitative measurements.
This study demonstrates that RNA interference (RNAi) targeting key metabolic genes in the whitefly *Bemisia tabaci* significantly reduces its population and induces high mortality in transgenic cassava, offering a promising long-term solution to control the vector of devastating cassava diseases in East Africa.