281 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
The paper introduces FOLIC, a novel foveated light-field compound imager that unifies wide-field context and single-cell resolution within a single capture to overcome traditional trade-offs in spatial resolution, field of view, and depth perception for biomedical applications.
This systematic review and meta-analysis of 28 in vivo animal studies demonstrates that experimental intervertebral disc injury consistently leads to mechanical and morphological deterioration, identifying Young's modulus as a sensitive indicator of functional degeneration while highlighting the need for methodological standardization to improve clinical translation.
The paper introduces Apollo-IRE1, a genetically encoded, ratiometric fluorescent sensor that enables live-cell, multiplexed imaging of ER stress dynamics by detecting IRE1 oligomerization through fluorescence anisotropy, offering a robust tool for studying beta-cell dysfunction in diabetes.
This study demonstrates that elastin-like recombinamer (ELR)-gelatin hydrogels with imprinted micro- and nano-gratings significantly accelerate endothelial monolayer formation by synergizing bioactive matrix chemistry with surface topography to enhance early cell capture and promote rapid, stable alignment.
This study enhances the efficacy and safety of genetically delivered TGF-β monomers for cancer immunotherapy and fibrosis treatment by incorporating a modified pro-domain to correct folding issues and fusing a CD44-binding domain to achieve over 30-fold increased inhibitory activity on target cells.
This study demonstrates that Ti3C2Tx MXene microelectrodes outperform conventional platinum electrodes in both recording and stimulation across various sizes (25–500 μm) due to reduced charge-transfer resistance and increased double-layer capacitance, with performance further enhanced by optimizing film thickness and concentration.
This paper presents a multi-objective optimization framework using particle swarm optimization to design a compliant, 3D-printed shoulder orthosis that effectively reduces muscle activity in healthy individuals while balancing gravity compensation with wearability constraints.
This study identifies a conserved hyaluronan-centered extracellular matrix regulatory axis linking traumatic brain injury, spinal cord injury, and neural implant responses, suggesting that HA-associated signatures can serve as minimally invasive biomarkers for monitoring neural injury and implant biocompatibility.
This study demonstrates that bioimpedance monitoring provides a real-time, waveform-agnostic metric for tracking cardiac electroporation during pulsed field ablation, while revealing that the procedure-induced increase in tissue conductivity homogenizes myocardial anisotropy, thereby supporting simplified modeling and the derivation of validated lethal electric field thresholds.
This study demonstrates that a retaining GH1 -glycosidase can be engineered through targeted mutations of second-shell residues to acquire -glycosidase activity while maintaining its native -function, thereby proving that the stereochemical constraints of this enzyme family are more flexible than previously thought.