234 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This study demonstrates that predictive simulations of post-stroke walking using a personalized neuromusculoskeletal model require a minimum level of feedforward synergy control combined with feedback mechanisms to accurately reproduce experimentally observed, dynamically consistent gait patterns.
This paper introduces detailed, reproducible training tutorials for the Neuromusculoskeletal Modeling (NMSM) Pipeline that guide novice users through creating personalized models and designing optimized clinical treatments for walking impairments, demonstrated through two real-world case studies involving knee osteoarthritis and post-stroke gait rehabilitation.
This study demonstrates that in a three-dimensional fibrillar microenvironment, dermal fibroblast activation and ECM remodeling are significantly driven by slow matrix stress relaxation rates, independent of and enhanced by matrix stiffness.
This manuscript, which originally proposed a modular nanostructure design for DX-tile DNA nano-stars to control the self-organization and viscoelastic properties of DNA hydrogels, has been formally withdrawn following an investigation by George Mason University's Office of Research Integrity and Assurance.
This paper has been withdrawn following a formal review by George Mason University's Office of Research Integrity and Assurance, and therefore contains no scientific findings to summarize.
The authors developed a magnetically activatable baculoviral system that spatially confines CRISPR-mediated *Pdl1* disruption to tumors, thereby coupling localized innate immune activation with sustained checkpoint blockade to enhance combination immunotherapy while minimizing off-target effects.
This paper introduces Lattice Sequence Vascularization (LSV), a multiscale computational framework that generates hierarchical, biomimetic vascular networks for 3D-printed biohybrid tissues by integrating biological constraints, synthetic properties, and manufacturing requirements to overcome perfusion limitations in large-scale constructs.
This study synthesizes nearly one million progeny data points from 42 publications to demonstrate that while species identity is the primary determinant of CRISPR/Cas9 gene drive performance, the specific combination of design choices rather than individual factors drives variability, ultimately providing a community resource to optimize future gene drives for vector control and invasive species management.
This study introduces a new family of poly(acrylamido) lipid-based PEG alternatives that significantly enhance mRNA-LNP transfection efficacy in immune cells and lymphoid tissues while successfully evading anti-PEG antibodies to restore therapeutic effectiveness during repeated dosing.
This study demonstrates that removing IgA and IgM via anion-exchange chromatography significantly enhances the efficiency and throughput of 20-nm nanofiltration for caprylic acid-purified IgG, offering a robust and scalable virus safety solution for plasma-derived immunoglobulin production in resource-limited settings.