281 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This study validates a novel, non-invasive in-ear AURIS sensor utilizing a PDMS substrate for monitoring heart rate variability during spinal cord neuromodulation, demonstrating gold-standard fidelity comparable to conventional chest electrodes and establishing a robust foundation for closed-loop bioelectronic medicine.
This study of university dining hall patrons reveals that animal-based meatballs significantly outperform plant-based alternatives in key sensory attributes like moistness, meatiness, and tastiness, suggesting that achieving sensory parity rather than emphasizing sustainability is crucial for increasing plant-based meat acceptance in institutional settings.
This study demonstrates that label-free optical metabolic imaging (OMI) using autofluorescence lifetime imaging can non-destructively resolve metabolic heterogeneity to accurately identify immune cell subtypes and activation states within heterogeneous peripheral blood mononuclear cell (PBMC) cultures, offering a promising tool for improved disease diagnostics and cell therapy development.
This study utilizes cryo-electron microscopy to reveal that kinetically enhanced ribosomes evolved via oRibo-PACE achieve elevated translation rates through specific 16S rRNA mutations that introduce localized structural destabilization and RNA-protein rearrangements, rather than altering conserved catalytic centers.
This study demonstrates that fusing CRISPR-Csm complexes with the RNA ligase RtcB enables programmable RNA excision and the creation of chimeric transcripts ("spligation") in living cells, offering a novel method for precise RNA manipulation independent of canonical splice sites.
This study demonstrates that acidity, rather than propionate ions alone, is the primary driver of propionic acid-induced inhibition in anaerobic digestion, causing severe methane production loss and significant microbial community restructuring that correlates strongly with process failure.
This paper presents a rapid, automated Raman spectroscopy method that achieves single-bead resolution and accurate quantification of residual immunomagnetic beads in cell therapy manufacturing, offering a robust alternative to time-intensive manual microscopy.
This study demonstrates that predictive simulations of post-stroke walking using a personalized neuromusculoskeletal model require a minimum level of feedforward synergy control combined with feedback mechanisms to accurately reproduce experimentally observed, dynamically consistent gait patterns.
This paper introduces detailed, reproducible training tutorials for the Neuromusculoskeletal Modeling (NMSM) Pipeline that guide novice users through creating personalized models and designing optimized clinical treatments for walking impairments, demonstrated through two real-world case studies involving knee osteoarthritis and post-stroke gait rehabilitation.
This study demonstrates that in a three-dimensional fibrillar microenvironment, dermal fibroblast activation and ECM remodeling are significantly driven by slow matrix stress relaxation rates, independent of and enhanced by matrix stiffness.