📄 Category

bioengineering

281 papers

Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.

At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.

📄 bioengineering

WITHDRAWN: Modular nanostructure design of DX-tile DNA nano-stars (DX-DNAns) controls self-organization and force propagation of DX-based DNA Hydrogels yielding a soft matter metamaterial with programmable viscoelastic properties and integrated functionalization

This manuscript, which originally proposed a modular nanostructure design for DX-tile DNA nano-stars to control the self-organization and viscoelastic properties of DNA hydrogels, has been formally withdrawn following an investigation by George Mason University's Office of Research Integrity and Assurance.

Bush, J.2026-03-03
📄 bioengineering

Magnetically activatable viral genome editing integrates antiviral sensing with checkpoint disruption for localized combination immunotherapy

The authors developed a magnetically activatable baculoviral system that spatially confines CRISPR-mediated *Pdl1* disruption to tumors, thereby coupling localized innate immune activation with sustained checkpoint blockade to enhance combination immunotherapy while minimizing off-target effects.

Yang, X., Tong, L., Pan, Y., Huang, J., Yi, Z., He, D., Liu, J., Wang, C., Liang, Y., Tong, S.2026-03-03
📄 bioengineering

Multiscale computational framework for generating vascularizedbiohybrid tissue constructs

This paper introduces Lattice Sequence Vascularization (LSV), a multiscale computational framework that generates hierarchical, biomimetic vascular networks for 3D-printed biohybrid tissues by integrating biological constraints, synthetic properties, and manufacturing requirements to overcome perfusion limitations in large-scale constructs.

Guy, A. A., Justin, A. W., Markaki, A. E.2026-03-03
📄 bioengineering

Cross-species meta-analysis reveals determinants of homing gene drive performance

This study synthesizes nearly one million progeny data points from 42 publications to demonstrate that while species identity is the primary determinant of CRISPR/Cas9 gene drive performance, the specific combination of design choices rather than individual factors drives variability, ultimately providing a community resource to optimize future gene drives for vector control and invasive species management.

Verkuijl, S. A. N., Ivimey-Cook, E. R., Liu, B., Bonsall, M. B., Leftwich, P. T., Windbichler, N.2026-03-03
📄 bioengineering

Poly(acrylamido) PEG-alternatives Enhance mRNA-LNP Efficacy in Immune Cells and Evade anti-PEG Antibodies During Repeated Dosing

This study introduces a new family of poly(acrylamido) lipid-based PEG alternatives that significantly enhance mRNA-LNP transfection efficacy in immune cells and lymphoid tissues while successfully evading anti-PEG antibodies to restore therapeutic effectiveness during repeated dosing.

Fiedler, B. M., Galley, C., Strimaite, M., Cheng, N. M., Mahmoudi, N., Feng, Z., Kalber, T. M., Martinez-Bravo, M.-J., M (…)2026-02-28
📄 bioengineering

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications

The paper introduces FLIP2, an expanded protein fitness benchmark featuring seven new datasets and real-world engineering splits that reveal simpler models often outperform fine-tuned protein language models in generalizing across diverse data distributions.

Didi, K., Alamdari, S., Lu, A. X., Wittmann, B., Johnston, K. E., Amini, A. P., Madani, A. K., Czeneszew, M., Dallago, C (…)2026-02-26
📄 bioengineering

Thermal Nano-Engineering of Ginger Extracellular Vesicles for Targeted Oral Therapy of Colitis

This study demonstrates that boiling ginger extracellular vesicles to create thermally reassembled nanoparticles (B-GEVs) enhances their surface composition for improved intestinal targeting and cellular uptake, enabling a synergistic oral therapy for colitis when loaded with TNF- siRNA.

Hou, L., Cao, J., Gao, S., Wang, X., Zhang, Z., Li, M., Mao, Y., Liu, c., Yan, L., Hao, H., Zheng, L.2026-02-26
📄 bioengineering

An injectable soft implant for long-acting, reversible, ultra-stable release of therapeutics

This paper presents an injectable, retrievable "soft implant" composed of surface-eroding poly(orthoester) microparticles within a hydrogel that achieves long-term, zero-order release of therapeutics for over six months, offering a transformative solution for improving patient adherence in treatments requiring sustained dosing.

Stevens, M. M., Kütahya, C., Panariello, L., Najer, A., Rizou, T., Shamsabadi, A., Brachi, G., Peeler, D. J., Zharova (…)2026-02-26