Design, Synthesis, and Evaluation of a novel Curcumin–Isoniazid Bis- Hydrazone Conjugate as an HIV-1 Reverse Transcriptase Inhibitor
This study reports the synthesis and characterization of a novel curcumin–isoniazid bis-hydrazone conjugate that demonstrates potent, concentration-dependent inhibition of HIV-1 reverse transcriptase with an IC₅₀ of 10.6 µM and favorable binding interactions, positioning it as a promising scaffold for further antiretroviral drug development.