Mechanistic Insights into Photocatalytic Proximity Labeling and Discovery of a Novel Photocatalyst for Interactome Profiling
This study establishes a standardized framework using site-specific antibody–photocatalyst conjugates to elucidate the mechanisms of photocatalytic proximity labeling and identifies BODIPY-FL as a novel, efficient photocatalyst that enables reduced-oxidation, spatially resolved interactome profiling in both cell-surface and intracellular environments.