Epidemiology is the study of how diseases spread through populations and what factors influence their patterns. Rather than focusing on individual patients, this field examines broader trends to identify outbreaks, track transmission, and guide public health decisions. By analyzing data on infection rates and risk factors, researchers work to prevent future health crises and protect communities worldwide.

On Gist.Science, we process every new preprint in this category directly from medRxiv to make these critical findings instantly accessible. For each study, we provide both a plain-language explanation for general readers and a detailed technical summary for specialists. This dual approach ensures that vital insights into disease dynamics are understood clearly and quickly by everyone who needs them.

Explore the latest research below to see how scientists are currently mapping disease trends and developing strategies to safeguard global health.

📊 epidemiology

An ecological study of the effect of white-tailed deer on alpha-gal syndrome in United States counties

This ecological study utilizes citizen science data and a front-door causal model to suggest that increased white-tailed deer abundance is associated with higher numbers of alpha-gal syndrome cases in the United States, though the authors caution that measurement errors and data limitations warrant careful interpretation of these estimates.

Piccininni, M., Cadahia, L., Stensrud, M. J.2026-08-20
📊 epidemiology

Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) among Children and Adolescents (<18 years) in India: A Systematic Review and Meta-analysis

This systematic review and meta-analysis of 11 studies involving 3,512 Indian children and adolescents reveals a high overall prevalence of non-alcoholic fatty liver disease (35.4%), with a disproportionately higher burden observed in overweight or obese high-risk groups (59.7%) compared to the general population (10.7%).

Abu Bashar, M., Prabhat,, Khan, I. A., Begam, N.2026-08-19
📊 epidemiology

Evaluation of the Leptocheck-WB IgM rapid test for acute leptospirosis among acute undifferentiated fever patients in western Uganda: very low sensitivity against locally circulating Leptospira serogroups

A study in western Uganda found that the Leptocheck-WB IgM rapid test has near-zero sensitivity (1.1–2.2%) for detecting acute leptospirosis caused by locally circulating serogroups, rendering it unsuitable for screening or surveillance in this setting despite its perfect specificity.

Kirabo, A. V., Alinaitwe, L., Ndawula, E. C., Kobba, K., Ogwang, J., Kirungi, M., Ndagire, A., Lamorde, M., Mayito, J. (…)2026-08-19
📊 epidemiology

Development and Validation of Interpretable Machine Learning Models for Early Prediction of Low Birth Weight in Ethiopia: A Secondary Analysis of the Ethiopian Demographic and Health Survey

This study demonstrates that interpretable machine learning models, particularly XGBoost, utilizing early pregnancy and sociodemographic data from the Ethiopian Demographic and Health Survey can accurately predict low birth weight risk to facilitate timely, targeted interventions in resource-limited settings.

Gebiru, A. M., Gebeyehu, S. B., Mihret, S. A., Ferede, K. T., Mamaye, Y.2026-08-19
📊 epidemiology

A Nationally Representative Study of Complementary and Alternative Medicine Therapies in relation to Sleep Duration and Insomnia Symptoms among US Adults

This nationally representative study found that US adults using complementary and alternative medicine therapies had a higher prevalence of short sleep duration and insomnia symptoms compared to non-users, a relationship likely driven by reverse causation where individuals with sleep disturbances seek out these treatments.

Singh, R., Gaston, S. A., Payne, C., Neo, D. T., Bertisch, S. M., Jackson, C. L.2026-08-19
📊 epidemiology

Childhood Bullying as a Cumulative Health Risk: A Dose-Response Analysis of Peer Victimization and Adult Mental and Behavioral Health Outcomes in Saudi Arabia

This national study in Saudi Arabia demonstrates a significant dose-response relationship between the frequency of childhood peer victimization and adverse adult mental and behavioral health outcomes, revealing that frequent bullying—particularly religion-targeted verbal abuse—substantially increases risks for substance use, anxiety, and suicidal ideation, with these effects amplified by socioeconomic disadvantage and partially mitigated by parental supervision.

Bin Hamdan, D. A.2026-08-19
📊 epidemiology

Detecting early loss of kidney function in a Sri Lankan cohort study of working age adults

This six-year longitudinal study of working-age adults in Sri Lanka reveals that nearly a quarter experienced declining kidney function and identifies smokeless tobacco use, smoking, and weedkiller exposure as significant risk factors for transitioning from healthy to unhealthy kidney states.

Chulasiri, P., Rutter, C. E., Gunawardena, N., Wickramasinghe, S., Niyas, R., Pearce, N., Caplin, B., Ruwanpathirana, T.2026-08-19
📊 epidemiology

Describing health inequalities without distortion: Simple-Means MAIHDA vs Random-Effects MAIHDA

This paper introduces Simple-Means MAIHDA (S-MAIHDA) as a distribution-free method that accurately describes health inequalities by using observed stratum data to avoid the distortion and attenuation of small-stratum effects caused by the shrinkage inherent in traditional Random-Effects MAIHDA.

Merlo, J., Bashir, N. Z., Rodriguez-Lopez, M., Khalaf, K., Öberg, J., Perez-Vicente, R.2026-08-18
📊 epidemiology

Rickettsiosis is the Leading Cause of Acute Undifferentiated Fever in Hoima, Uganda: A Prospective Health Facility-based Study

This prospective study in Hoima, Uganda, reveals that rickettsiosis is the leading cause of acute undifferentiated fever, surpassing malaria and leptospirosis in prevalence, and underscores the need to update clinical guidelines to include empiric doxycycline treatment and improved diagnostics for malaria-negative patients with relevant environmental exposures.

Kirabo, A. V., Oakley, R., Kobba, K., Ndawula, E. C., Plag, M., Ogwang, J., Kirungi, M., Ndagire, A., Nickel, B., Lamord (…)2026-08-17