368 papers
Genomics is the study of an organism's complete set of DNA, offering a deep dive into the biological instructions that shape life. This field explores how genetic information influences traits, health, and evolution, moving beyond single genes to understand the complex interplay within entire genomes. From uncovering the roots of disease to mapping biodiversity, genomics provides the foundational data for many modern medical breakthroughs.
At Gist.Science, we process every new preprint in this category as it appears on bioRxiv, ensuring you stay ahead of the curve. Each paper is accompanied by both a clear, plain-language overview and a detailed technical summary, making cutting-edge research accessible to everyone regardless of their background. Below are the latest papers in genomics, freshly summarized and ready for you to explore.
This study reveals the unprecedented abundance and diversity of endogenous virophages and Polinton-like viruses within the genome of the halophilic protist *Halocafeteria seosinensis*, highlighting their complex genetic exchange, supraparasitism by mobile elements, and significant contribution to the host's genomic landscape.
Using long-read sequencing and Omni-C data, this study resolves the complex evolutionary history of the cultivated dahlia by assembling a tetraploid genome for *Dahlia variabilis* 'Edna C' and identifying it as a segmental tetraploid with signatures of both auto- and allopolyploidy.
This study demonstrates that three generations of early-life metabolic challenges in mice induce genome instability and constrain genetic variability through transposable element activity and copy number variations, rather than through widespread DNA methylation changes.
This study utilized genome-wide association analysis on 384 elite UK wheat genotypes to identify seven genetic loci, including major stable effects on chromosomes 1B and 6B, that regulate water-extractable arabinoxylan content, demonstrating that pyramiding favorable alleles within existing germplasm offers a practical strategy for breeding wheat with enhanced dietary fibre.
This study reveals that TRIM28 preserves ovarian cell identity primarily by acting as a transcriptional co-regulator that stabilizes lineage-specific transcription factor hubs (such as FOXL2 and NR5A2) through SUMOylation, rather than by maintaining H3K9me3-dependent heterochromatin.
This study constructs a comprehensive multidimensional genetic variation map of over 8,000 complete human centromeres by integrating diverse genome assemblies, revealing extensive structural diversity, population stratification, and a dual-track evolutionary model that balances structural innovation with mutational constraint while providing a critical resource for understanding centromere biology and associated disorders.
This study utilizes genome-wide data to provide the first estimates of genetic load in mule deer and updated runs-of-homozygosity assessments for white-tailed deer, revealing elevated inbreeding in Key deer and increased genetic load in Pacific Northwest mule deer populations due to historical bottlenecks.
This study utilizes Perturb-seq in a physiologically relevant epidermal organoid model to uncover genetic drivers of keratinocyte differentiation and reveal the bidirectional role of non-canonical NF-κB signaling in late differentiation, overcoming the limitations of previous 2D culture-based screens.
By integrating genome-wide epigenomic profiles, this study identifies five principal chromatin states and reveals that cell-type-specific differences are primarily driven by the remodeling of Polycomb-associated chromatin, while CTCF-associated chromatin serves as a key architectural anchor linking chromatin organization to three-dimensional genome structure.
By analyzing over 1,100 *Arabidopsis thaliana* genomes, this study identifies a complex genetic architecture involving both cis- and trans-acting loci that regulate repeat abundance and reveals that purifying selection acts to constrain rapid genome content divergence.