415 papers
Genomics is the study of an organism's complete set of DNA, offering a deep dive into the biological instructions that shape life. This field explores how genetic information influences traits, health, and evolution, moving beyond single genes to understand the complex interplay within entire genomes. From uncovering the roots of disease to mapping biodiversity, genomics provides the foundational data for many modern medical breakthroughs.
At Gist.Science, we process every new preprint in this category as it appears on bioRxiv, ensuring you stay ahead of the curve. Each paper is accompanied by both a clear, plain-language overview and a detailed technical summary, making cutting-edge research accessible to everyone regardless of their background. Below are the latest papers in genomics, freshly summarized and ready for you to explore.
This study presents a high-quality, chromosome-scale genome assembly of the Swiss *Lolium multiflorum* ecotype Tremona and introduces a scalable tool called ParaLies to effectively purge spurious duplications caused by heterozygosity, thereby significantly improving assembly accuracy for this complex forage species.
This paper introduces MILK, a scalable computational framework that organizes massive single-cell genomic datasets into unified hierarchical tree representations to enable efficient subsampling, preserve multi-resolution cellular relationships, and facilitate integrative analyses across tissues, developmental stages, and species.
The Maize Genetics and Genomics Database (MaizeGDB) has enhanced its analytical capabilities by integrating JBrowse2 with a new Pangenome Viewer, enabling interactive visualization of both linear and graph-based pangenomes to facilitate precise characterization of structural variations and agronomic traits in maize.
Using a copper-inducible DNA methyltransferase system in living *S. pombe* cells, this study demonstrates that both euchromatin and heterochromatin are globally accessible in vivo, revealing that the H3K9 methylation and HP1/Swi6 system does not limit DNA accessibility and that the observed inaccessibility in isolated nuclei is an artifact of tight nucleosome spacing rather than a biological repressive mechanism.
This pilot study reveals that conspicuous color variation within a single clonal chalice coral colony is driven by region-specific up-regulation of distinct fluorescent protein transcripts and photoconvertible EosFP-family proteins, rather than genetic differences.
This study resolves the highly heterozygous F1 hybrid oil palm genome into complete haplotypes to reveal how complementary genomic remodeling, ancient introgressions, and balanced allelic expression coordinate distinct parental traits to drive heterosis.
This study presents the first chromosome-scale genome assembly of *Blumeria graminis* f. sp. *avenae*, revealing that its host specialization is driven by the localized diversification of pathogenicity genes within transposable element-rich, structurally dynamic genomic regions rather than large-scale genome restructuring.
This study presents a high-quality, subgenome-resolved, chromosome-scale reference genome assembly of the drought-tolerant and stem rust-resistant allotetraploid wheat wild relative *Aegilops peregrina* (PI 604178), generated using PacBio HiFi and Hi-C sequencing to provide a robust genomic framework for wheat improvement.
By integrating epigenomics and AI across 240 placental mammals, this study reveals that cell-type-specific aging programs driving neurodegenerative vulnerability are subject to distinct selective pressures in long-lived species, challenging the notion of a single master regulator of aging.
This study presents high-quality, haplotype-resolved chromosome-level genome assemblies and annotations for four European white oak species (*Quercus robur*, *Q. petraea*, *Q. pubescens*, and *Q. frainetto*), providing a standardized genomic framework to advance comparative analyses, pangenome construction, and evolutionary studies within this ecologically and economically important group.