🧬 Category

genomics

415 papers

Genomics is the study of an organism's complete set of DNA, offering a deep dive into the biological instructions that shape life. This field explores how genetic information influences traits, health, and evolution, moving beyond single genes to understand the complex interplay within entire genomes. From uncovering the roots of disease to mapping biodiversity, genomics provides the foundational data for many modern medical breakthroughs.

At Gist.Science, we process every new preprint in this category as it appears on bioRxiv, ensuring you stay ahead of the curve. Each paper is accompanied by both a clear, plain-language overview and a detailed technical summary, making cutting-edge research accessible to everyone regardless of their background. Below are the latest papers in genomics, freshly summarized and ready for you to explore.

🧬 genomics

Improved genome assemblies of plant-associated Streptomyces spp. as a resource for understanding plant pathogenicity in the genus

This study presents high-quality genome assemblies for 18 Streptomyces type strains, revealing that phytopathogenic species possess larger genomes enriched in metabolic genes, exhibit significant chromosomal rearrangements, and do not rely on conserved plasmids for pathogenicity, thereby providing a crucial resource for understanding plant disease mechanisms.

Shelley, B. A., Fabian, M. L., Nguyen, H. P., Weisberg, A. J., Chang, J. H. H., Clarke, C. R.2026-08-22
🧬 genomics

Complete mitochondrial genomes of Arizona West Nile virus vectors, Culex quinquefasciatus and Culex tarsalis

This study reports the first complete mitochondrial genomes of West Nile virus vectors *Culex quinquefasciatus* and *Culex tarsalis* from Arizona, utilizing a novel long-range PCR and Pacific Biosciences HiFi sequencing method to reveal unique genomic features and establish a new approach for global vector population surveillance.

Barrand, Z. A., Ridenour, C. L., Erickson, D. E., Rivas, A. N., Schmidt, B. K., Will, J., Young, S. J., Busser, N., Town (…)2026-08-21
🧬 genomics

Low-heteroplasmy mitochondrial DNA mutations improve clonal reconstruction of human cells

This study demonstrates that by applying stringent error filtering, low-heteroplasmy mitochondrial DNA mutations can be effectively utilized as abundant, bona fide lineage barcodes to significantly enhance the resolution of clonal reconstruction in human cells without the need for genetic engineering.

weng, c., Gao, T., Colgan, W., Johnson, I., Gudera, J., Poeschla, M., Weissman, J. S., Sankaran, V. G.2026-08-21
🧬 genomics

Spatial mapping of cellular and molecular plasticity in the maternal and postpartum mouse brain

By integrating three single-cell spatial technologies to profile 1.5 million cells across the maternal mouse brain, this study reveals distinct pregnancy-associated molecular programs in neurons and glia and identifies a dynamic concentration of depression risk genes in specific remodeling circuits, offering a cellular basis for peripartum vulnerability.

Arbabi, K., Ghazisaeidi, S., Kim, M., Kukreja, B., Feng, M. Y., Pogue, S., Hudson, H., Fafouti, M. E., Crouch, E., Galea (…)2026-08-19
🧬 genomics

Chromosomal instability shapes spatial and temporal phenotypic diversity in a malignant peripheral nerve sheath tumour

By integrating single-cell and spatial multi-omics with native barcoding, this study elucidates how chromosomal instability drives the spatial and temporal phenotypic diversity of a malignant peripheral nerve sheath tumour by linking gene dosage effects to evolutionary branching and microenvironmental interactions.

Yan, H., Demeulemeester, J., Verfaillie, A., Cheng, Y., Pan, Y., Cotobal Martin, C., Ward, S., Stein, A., Lesluyes, T. (…)2026-08-18
🧬 genomics

Phylogenomics and comparative genomics of the genus Erwinia reveal taxonomic inconsistencies and evolutionary diversification

This study utilizes comprehensive phylogenomic and comparative genomic analyses of 104 *Erwinia* strains to resolve evolutionary relationships, identify taxonomic inconsistencies, and demonstrate how lineage-specific genomic plasticity drives ecological adaptation and pathogenicity through diverse combinations of virulence factors.

Maurya, N., Dobhal, S., Sundin, G. W., Rodoni, B., Stack, J. P., Arif, M.2026-08-11