392 papers
This study reveals that despite diverse lung insults, monocyte-derived alveolar macrophages follow a conserved, hard-wired differentiation blueprint involving EGR2-mediated rewiring that establishes a stereotypical, protective phenotype, whereas fetal-derived macrophages exhibit more context-dependent plasticity.
This study reveals that age dictates NK cell fate and tissue distribution during CMV infection, showing that infant NK cells develop distinct adaptive-like responses and seed tissues to compensate for limited T cell immunity, whereas adult responses are shaped by competition with memory T cells.
This study demonstrates that autoantibodies against the epithelial integrin αvβ6, which are specific biomarkers for ulcerative colitis, actively inhibit mucosal TGFβ activation, disrupt epithelial homeostasis, and increase susceptibility to intestinal inflammation.
This study demonstrates that knocking down the long isoform of the prolactin receptor (LFPRLR) using a splice-modulating oligomer selectively targets pathogenic immune cells, reduces type I interferon signaling and autoreactive antibodies, and prevents lupus nephritis in SLE-prone mice without harming healthy immune cells, offering a promising new therapeutic strategy for systemic lupus erythematosus.
This study characterizes the regional variations in epithelial thickness and the spatial distribution of T and B lymphocytes across the human fallopian tube, revealing that while epithelial thickness varies by anatomical region but not menstrual phase, both lymphocyte populations are abundant, correlated, and preferentially localized within the mucosal compartment, including the presence of intraepithelial B cells.
The PETIL machine-learning model, developed using data from Moffitt Cancer Center, successfully predicts the expansion of tumor-infiltrating lymphocytes in bladder cancer patients to optimize patient selection for adoptive cell immunotherapy, achieving strong performance metrics (AUC up to 0.857) in both testing and blinded validation cohorts.
This study demonstrates that antibody feedback significantly diversifies both primary and secondary humoral immune responses even at low antibody levels, providing critical insights for designing sequential vaccination strategies against highly variable pathogens like HIV-1 and Influenza.
This study reveals that m6A modifications on both mumps virus RNA and host transcripts bidirectionally regulate viral pathogenesis by simultaneously constraining viral replication and modulating host innate immune responses.
This study presents a novel, dose-efficient platform for *in vivo* generation of armoured CAR T cells using CD8-targeted lipid nanoparticles and a T-cell-restricted mRNA strategy to deliver transient, tunable CAR and IL-12 expression, thereby enhancing safety, efficacy, and tumour control while overcoming the limitations of traditional ex-vivo therapies.
This study successfully developed a seven-gene modified donor pig (BM7G) by combining CRISPR-Cas9-mediated knockout of three glycan antigens with site-specific integration of four human protective genes driven by endogenous promoters, resulting in a model with stable, tissue-specific expression that effectively reduces immunogenicity and thrombosis for xenotransplantation.
This study utilizes a mechanistic within-host model to demonstrate that low-to-intermediate antibody levels combined with low CD8+ T-cell immunity drive antibody-dependent enhancement (ADE) and severe dengue, suggesting that future vaccine designs must prioritize inducing robust CD8+ T-cell responses to mitigate this risk.
This study demonstrates that antibody maturation in germinal centers is driven by the selection of B cell receptor-antigen bonds with enhanced mechanical resistance rather than increased binding affinity, a mechanism that correlates with functional outcomes like NK cell activation.
This study demonstrates that *Pseudomonas aeruginosa* variants lacking the H3-T6SS exploit host-derived itaconate to enhance their metabolic fitness and survival within phagolysosomes, thereby facilitating persistent pulmonary infections.
This study demonstrates that an injectable polymer nanoparticle hydrogel platform for the sustained delivery of a shingles subunit vaccine overcomes age-related immune decline in mice by eliciting more potent and durable humoral and cellular responses than the current standard Shingrix vaccine, while simultaneously mitigating reactogenicity.
This study demonstrates that the route of Rift Valley fever virus inoculation in sheep significantly alters disease pathogenesis, immune response, and viral excretion, with subcutaneous infection facilitating horizontal transmission while intranasal infection leads to more severe clinical and histopathological outcomes.
This study demonstrates that intranasal and intramuscular administration of an adenovirus type 5-vectored influenza vaccine to pregnant pigs effectively induces maternal immunity that is passively transferred to neonates, with the intranasal route showing superior efficacy in generating neutralizing antibodies.
This study demonstrates that spike antibody-dependent complement deposition and Fc{gamma}R binding, particularly when driven by specific glycosylation patterns, serve as strong candidate correlates of protection against both viral load and lung pathology in SARS-CoV-2-challenged macaques, highlighting the critical role of functional antibody characteristics beyond neutralization in vaccine efficacy.
This study demonstrates that bivalent S-EABR mRNA-LNP boosters, which encode engineered immunogens inducing virus-like particle budding, elicit superior and more diverse polyclass receptor-binding domain antibody responses against SARS-CoV-2 variants in pre-vaccinated mice compared to conventional boosters, suggesting a promising strategy for broader and more durable protection.
Using genetically modified mice, this study reveals that while Type I interferon subtypes non-redundantly cooperate to prevent systemic viral dissemination, IFN-β is the critical individual subtype for survival, and distinct pathways involving different subtypes and promoter elements are sequentially required to protect vital organs like the brain from viral infection.
By fitting mathematical models to ultra-low dose infection data, this study reveals that BCG vaccination primarily reduces Mycobacterium tuberculosis dissemination between murine lungs by 89% through modestly curbing bacterial replication, thereby providing a rigorous framework for evaluating next-generation TB vaccines.