212 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study provides the first integrated multiomic profile of extracellular vesicles from wild-type EBV-transformed B-cells, revealing that they export abundant host DNA and the viral lncRNA EBER1 while containing minimal viral DNA, thereby suggesting a vesicle-mediated mechanism for delivering viral RNA to distal tissues like the CNS in multiple sclerosis.
This study presents a germinal center conditional expression mouse model that bypasses tolerance checkpoints and accelerates the maturation of stalled VRC01-class HIV-1 broadly neutralizing antibodies, demonstrating a strategy to overcome roadblocks in vaccine design by guiding B cells through necessary mutational steps to achieve heterologous neutralization.
Cipolla et al. demonstrate that pre-existing antibodies enhance germinal center and plasmablast responses through Fc gamma receptor-dependent mechanisms while simultaneously lowering the affinity threshold for B cell entry via Fc gamma receptor- and complement receptor-independent pathways.
This study demonstrates that intestinal epithelial cells presenting bacterial antigens injected via the type 3 secretion system are essential for driving robust CD4 T cell responses and programming tissue-resident memory, highlighting a critical role for non-professional antigen presentation in mucosal immunity and vaccine development.
This study introduces the Quantitative Extrapolation from Single-tags (QuEST) immunofluorescence microscopy method to calibrate fluorescence signals against molecular copy numbers, revealing a 1:1 ZAP-70:TCR stoichiometry in human primary T cells and demonstrating that PD-1 engagement disrupts intrinsic CD28 recruitment during TCR activation.
This study establishes novel type I and type III interferon receptor knockout chicken models to demonstrate that type I interferon is critical for innate and adaptive immune regulation, while both interferon types play strain-specific roles in orchestrating pathogenesis and tissue tropism during avian influenza infection.
This study utilizes high-dimensional multiomics to reveal that CD4+ T cells undergo significant molecular adaptations during the third trimester of pregnancy, characterized by perturbations in the IL-6/IL-6R axis and RUNX3 expression, which offer mechanistic insights into placental development and potential targets for treating pregnancy complications.
This study reveals that cirrhosis-associated immune dysfunction is characterized by preserved but hyper-inflammatory peripheral T-cell function alongside a distinct remodeling of the intestinal intraepithelial lymphocyte compartment, specifically marked by the loss of CD8β+ cells and altered gut-homing capabilities.
This study identifies a conserved metabolic-oxidative axis, driven by activation-induced glucose utilization and ROS production, as the primary cause of immune cell cryo-vulnerability and demonstrates that targeting this pathway with metabolic inhibitors and antioxidants can significantly restore post-thaw viability and antitumor efficacy across multiple immune cell types.
This study reveals that porcine STING stability and antiviral signaling are species-specifically regulated by RNF5-mediated K48-linked ubiquitination at lysine 61, which targets the protein for proteasomal degradation, a process counteracted by the deubiquitinase USP20 to enhance antiviral immunity.