392 papers
This study demonstrates that a novel "Hybrid" CAR-T cell platform, which combines targeted cytotoxicity with the secretion of broadly neutralizing antibodies, effectively suppresses HIV in humanized mice by simultaneously eliminating infected cells, neutralizing free virus, and recruiting Fc-mediated effector functions.
This study demonstrates that repurposing the FDA-approved drug Disulfiram to inhibit Gasdermin D significantly attenuates cardiac inflammation and fibrosis while improving cardiac function following ischemia-reperfusion injury in mice.
This study introduces CanonicalTockySeq, a novel framework that integrates a TCR signalling molecular clock with scRNA-seq to resolve the temporal dynamics of T-cell fate decisions, revealing that effective cancer immunotherapy relies on reducing persistent antigen engagement and exhaustion signalling while preserving progenitor-like features.
This study validates a CD101-tdTomato reporter mouse model as a robust tool for specifically tracking mature neutrophils, confirming that CD101 remains a reliable marker of neutrophil maturity even under pathological conditions where protein levels may appear reduced.
This study reveals that CAR-macrophages can activate anti-tumor T cells and drive therapeutic efficacy through non-phagocytic CAR signaling and cytokine release, demonstrating that target cell uptake is not required for their immune-activating functions.
This study establishes an optimized workflow combining NK cell activation, specific construct design, and transduction enhancers (BX795 and Retronectin) to achieve efficient transduction of NK cells using VSV-G-pseudotyped lentiviral vectors, thereby enabling the safe production of off-the-shelf CAR-NK cell therapies.
Caloric restriction in SIV-infected rhesus macaques enhances acute viral control through metabolic reprogramming and reduces chronic inflammation during antiretroviral therapy, although it does not eliminate viral persistence.
This study characterizes unique structural and genetic features of antibody responses against influenza A H3 in mallard ducks, revealing how millennia of coevolution in natural reservoirs have shaped distinct mechanisms—such as enhanced glycan binding, balanced immunodominance, and gene conversion—that maintain viral antigenic stability despite immune pressure.
This study demonstrates that NLRP3 functions as a direct sensor of intracellular potassium ions, where high K+ concentrations stabilize an inactive, compact conformation while K+ efflux induces an open, active state that triggers inflammasome assembly and inflammation.
Using a high-resolution FRET-based biosensor, this study reveals that TCR engagement triggers the selective internalization of inactive Lck while retaining active Lck at the immune synapse, establishing a spatially confined signaling architecture governed by the differential regulation of free versus CD8-bound Lck conformations.
This study reveals that TET2-mutant clonal hematopoiesis suppresses cancer metastasis by preventing CD8+ T-cell exhaustion through DNA hypermethylation of the Tox transcription factor, thereby maintaining a stem-like, effector-competent immune state.
This study establishes that a minimally invasive intact-chest myocardial infarction model more accurately replicates human immune responses than the standard open-chest approach by preserving bone marrow integrity, thereby revealing that the accumulation of immature neutrophils drives adverse cardiac remodeling.
The study introduces CUE-401, a novel bifunctional fusion protein that coordinates IL-2 and TGF-β signaling to selectively expand and activate regulatory T cells, thereby inducing immune tolerance and providing long-term protection against autoimmune diseases without broadly activating conventional T cells.
This study demonstrates that engineering CD93-targeting CAR T cells with a VE-cadherin-based inhibitory NOT-gate effectively preserves healthy endothelial integrity while maintaining potent anti-leukemic activity against acute myeloid leukemia, thereby overcoming a major barrier to clinical translation.
By integrating high-resolution cryoEM-based polyclonal epitope mapping with machine learning, this study identifies the structural determinants of HIV Env immunodominance and demonstrates that model-guided immunogen redesign can successfully redirect antibody responses toward subdominant epitopes.
This study identifies a sex-specific mechanism where the GUGCA seed motif-driven miR-130b network impairs B cell tolerance by downregulating Esr1 and Pten, leading to compensatory PI3K-AKT signaling and autoreactive B cell escape in females, thereby elucidating a molecular basis for female predisposition to autoimmunity.
This study reveals that severe COVID-19 is characterized by a distinct high-interferon endotype where metabolic disruptions, particularly in lipid and TCA cycle pathways, functionally impair innate immune activation despite elevated interferon-stimulated gene expression, highlighting a critical immune-metabolic axis in disease severity.
This study identifies Glycophorin Binding Protein-130 (PfGBP-130) as the previously unknown ligand on *Plasmodium falciparum*-infected red blood cells that binds to LFA-1, thereby mediating Natural Killer cell activation and parasite control.
This study isolates and characterizes human monoclonal antibodies targeting the SFTSV Gn glycoprotein, using deep mutational scanning and cryo-EM to identify four neutralizing epitope groups and validate two potent candidates (BD70-4003 and BD70-4017) that offer complete protection in a lethal mouse model.
By analyzing multimodal single-cell data from 2.1 million immune cells across 346 donors, this study identifies previously uncharacterized T cell populations and their molecular drivers that are distinctively associated with systemic lupus erythematosus severity and treatment, offering new insights for therapeutic target discovery.