212 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
The study demonstrates that the signaling molecule D-β-hydroxybutyrate enhances mitochondrial ATP production via oxidative phosphorylation, which suppresses stress responses and promotes chromatin accessibility at effector gene loci to drive CD8+ T cell differentiation and potent antitumor immunity.
This study demonstrates that 5-Azacytidine enhances anti-leukemic immunity in myeloid malignancies by epigenetically reprogramming the myeloid niche to drive an S100A8/A9-mediated inflammatory cascade that licenses the functionality of immature NK cells, a mechanism supported by both preclinical models and clinical cohort data.
This study demonstrates that ocrelizumab treatment in multiple sclerosis not only depletes B cells but also modulates T cell populations and enriches anergic, regulatory B cell subsets with enhanced IL-10 signaling and tissue-homing capabilities, thereby establishing a self-reinforcing regulatory immune circuit.
This study reveals that mouse and human embryonic stem cells utilize an interferon-independent innate immune pathway where the RNA helicase Dhx9 stabilizes p53 and Stat1 to drive an interferon-stimulated gene response against dsRNA and viral infections like ZIKV.
This study demonstrates that in vivo diffusion-weighted magnetic resonance spectroscopy can detect age-related differences and acute IFN-β-induced increases in thalamic choline-containing metabolite diffusivity, providing a non-invasive signature of inflammation-driven glial morphological changes.
This study demonstrates that depleting extracellular asparagine impairs the activation, mitochondrial function, and cytokine production of autoreactive CD4+ T cells, thereby reducing disease severity in murine models of multiple sclerosis and suggesting a novel therapeutic strategy for autoimmunity.
This study demonstrates that targeted somatic evolution of an inherently cross-reactive IGHV3-53 germline antibody, guided by structural analysis, can restore and enhance neutralization against immune-escaping SARS-CoV-2 Omicron variants, offering a blueprint for engineering resilient antibody responses.
This study characterizes Fireko mice, a novel model with germ-line deletion of the Csf1r enhancer FIRE that selectively depletes specific tissue-resident macrophages while preserving normal development and organ function, thereby providing a unique platform to investigate macrophage roles in homeostasis and disease.
This study reveals that the cellular targets of IL-17 signaling in inflammatory skin diseases are context-dependent, with dermal fibroblasts acting as the primary mediators in hidradenitis suppurativa-like inflammation while both fibroblasts and keratinocytes contribute to psoriasis-like inflammation.
This study reveals that rare individuals who naturally control HIV rebound after treatment cessation exhibit distinct, early immune signatures characterized by pre-rebound activation and reduced systemic inflammation, suggesting that immunotherapies can similarly induce protective pre-rebound immune responses.