392 papers
This study reveals that patients with chronic coronary syndrome exhibit delayed neutrophil apoptosis and a pro-inflammatory phenotype that is resistant to regulatory T cell-induced apoptosis, suggesting that neutrophil dysfunction contributes to persistent inflammation in this condition.
This study identifies that macrophage SLC9A1 links endocytic trafficking to innate immune activation by promoting the uptake of danger signals and subsequent inflammatory signaling, thereby driving adverse cardiac remodeling after myocardial infarction.
This study demonstrates that mast cell-specific ablation of the steroid synthesis enzyme Cyp11a1 suppresses melanoma metastasis to the lungs by enhancing T cell-mediated immunity and immune cell activation, revealing a novel regulatory role for mast cell-derived steroids in tumor progression.
This study establishes a framework for designing immunogenic peptidomimetic antigens by systematically evaluating how position-dependent backbone modifications to the SIINFEKL epitope differentially impact MHC-I binding, TCR recognition, and metabolic stability, revealing that specific N-methylated variants can enhance cellular permeability without compromising immune activation.
This study reveals that intestinal IL-17RC signaling protects against atherosclerosis by maintaining gut barrier integrity and microbiota homeostasis, thereby preventing microbiota-driven T cell activation that promotes perivascular neuronal outgrowth and subsequent neuroimmune inflammation in the aorta.
Acute paternal immune activation remodels sperm small RNAs to reprogram embryonic gene expression, resulting in male offspring with enhanced survival against lethal viral challenges.
This study utilizes high-dimensional flow cytometry to map socioeconomic status-associated immune diversity across Senegalese and European cohorts, revealing that lower SES correlates with downregulated surface adhesins and receptors alongside markers of chronic activation, while higher SES is linked to superior protein translation rates.
This study reveals that in pediatric eosinophilic esophagitis, disease severity is driven not merely by eosinophil burden but primarily by epithelial cell-state transitions involving impaired differentiation, metabolic stress, and structural remodeling, offering a new framework for understanding and treating the condition.
This study demonstrates that FcRn-mediated recycling of apoB-specific IgG antibodies by macrophages drives atherosclerotic plaque vulnerability through increased inflammation and extracellular matrix degradation, identifying FcRn as a promising therapeutic target.
This paper employs a stochastic spatial model to demonstrate that variability in viral release timing asymmetrically influences infection outcomes, where stochastic initiation accelerates viral expansion while precise timing benefits host defense, ultimately highlighting the central role of signal timing noise in early infection dynamics.
This study reveals that dietary vitamin A, via retinoic acid receptor signaling, directly enhances intestinal innate immunity by promoting the transcription of antimicrobial REG3 lectins and defensins through a mechanism that integrates nutritional cues with microbiota-induced STAT3 signaling.
This study demonstrates that a safe, adaptable single-cycle SARS-CoV-2 vaccine candidate engineered with an XBB.1.5 Spike protein effectively prevents disease and blocks viral transmission in animal models, outperforming current bivalent mRNA vaccines.
This study demonstrates that GonoVac, a candidate native gonococcal outer membrane vesicle vaccine, elicits superior functional immune responses and serum bactericidal activity against *Neisseria gonorrhoeae* in mice and rabbits compared to the meningococcal vaccine 4CMenB, supporting its further development as a promising preventive measure for gonorrhea.
Using single-cell RNA sequencing of cerebrospinal fluid from HIV-associated tuberculous meningitis patients, this study identifies a hyperinflammatory pathology characterized by the accumulation of granzyme-rich cytotoxic CD8 T cells, highly activated neutrophils, and detrimental type 1 interferon signaling that correlates with bacterial load and treatment response.
This study utilizes single-cell analysis of neonatal cord blood to identify a distinct, fetally-derived subset of innate-like naive CD8β+ T cells (FITs) characterized by a KLRG1+CD161+ phenotype and unique transcriptomic features, which are rarely found in adults and can be distinguished from other unconventional T cell populations by their T cell receptor repertoire.
This pilot study establishes a new porcine model of irreversible anaphylactic shock by demonstrating that hemoperfusion with a carbon-cellulose cartridge (Adsorba® 300C) triggers a fatal, complement-mediated pseudoallergic reaction characterized by profound hemodynamic collapse, thereby providing a clinically relevant system to investigate extracorporeal circulation-induced immune responses.
This study demonstrates that amoxicillin-induced gut dysbiosis leads to long-lasting suppression of type-17 immune tone in the lungs, thereby compromising pulmonary host defense even after antibiotic treatment has ceased.
This study demonstrates that displaying the *E. coli* FimH antigen on I53-50 nanoparticles significantly enhances its immunogenicity, eliciting robust receptor-blocking antibodies in mice and non-human primates comparable to high-dose monomeric formulations, thereby validating a promising nanoparticle-based vaccine strategy for preventing urinary tract infections.
This prospective observational study reveals that patients with Legionnaires' disease requiring ICU admission exhibit significantly more pronounced immune gene expression alterations and functional deficits in response to LPS stimulation compared to non-ICU patients, suggesting that a reduced expression of key genes involved in controlling bacterial proliferation contributes to increased disease severity.
This study reveals that HIV-1 Vpr promotes infection by inducing the degradation of the restriction factor TASOR, which inhibits viral replication prior to integration, thereby overcoming a critical host defense mechanism through a process dependent on CRL4-DCAF1 interaction and nuclear localization.