392 papers
Contrary to the hypothesis that integrins facilitate entry, this study reveals that T-cell acute lymphoblastic leukemia lacking VLA-4 and LFA-1 integrins accumulates more extensively in the central nervous system due to accelerated proliferation, suggesting that blocking these integrins could synergize with chemotherapy to improve treatment outcomes.
This study demonstrates that the murine protein IFI207 enhances antiviral immunity by inhibiting K63-linked ubiquitination and subsequent lysosomal degradation of STING, thereby amplifying type I interferon responses and controlling viral infections such as Murine Leukemia Virus and Herpes Simplex Virus 1.
The authors developed NanoMAP, an integrated experimental and computational pipeline that outperforms standard methods in characterizing alpaca immune repertoires by identifying coherent, high-affinity nanobody clonal families through deep sequencing and diverse panning strategies, thereby significantly enhancing nanobody discovery capabilities.
This study demonstrates that selective JAK2 inhibition, rather than broad or JAK3-targeted approaches, is the most effective strategy for treating AIRE-deficiency-driven autoimmunity by directly suppressing the dominant IFN-γ signaling axis while preserving other essential immune functions.
This study demonstrates that "dirty" mice with broad microbial exposure better recapitulate human immune responses to SARS-CoV-2 mRNA vaccines than traditional SPF mice, as they exhibit reduced antibody titers, faster waning, and a requirement for booster doses similar to those observed in humans.
This study reveals that membrane tension, generated by cell swelling during necrosis, drives the zipper-like opening of NINJ1 double filaments to form membrane lesions and execute cell lysis, a mechanism distinct from the stable NINJ2 homolog.
This study reveals that during *Plasmodium* infection, multiple temporally overlapping mechanisms—including Myc-driven expansion, early class switch recombination, and germinal center-mediated somatic hypermutation—combinatorially diversify individual B cell clones to amplify and safeguard humoral immunity, while anti-malarial treatment limits the magnitude but not the rate of this diversification.
This study identifies neutrophil myeloperoxidase (MPO) as a critical biomarker for RSV severity and demonstrates its utility as a functional readout in a physiologically relevant in vitro model to screen therapeutics that effectively reduce neutrophil-driven inflammation.
This study demonstrates that GM-CSF acts as a critical spatial regulator in Crohn's disease by mediating myeloid-lymphoid crosstalk to restrain ILC1 expansion, sustain ILC3 maintenance, and promote IL-22 production, thereby limiting epithelial injury and inflammation in ulcerated intestinal regions.
This study demonstrates that daily cannabis use in people with HIV is associated with reduced neurocognitive deficits and an anti-inflammatory, neuroprotective immunometabolic reprogramming of monocyte-derived macrophages, characterized by a shift toward oxidative phosphorylation, increased mitochondrial numbers, and favorable cytokine and BDNF profiles.
This study identifies a novel IRF4-dependent monocyte-to-antigen-presenting cell axis that promotes skin wound healing via IL27-mediated Treg activation, a pathway that is impaired in diabetic mice and represents a potential therapeutic target.
This study demonstrates that in HIV vaccine development, the efficiency of priming rare bnAb precursors followed by the early dominance of specific expanded clones is a critical determinant for achieving broad serum neutralization, as evidenced by successful recall and affinity maturation upon subsequent SHIV challenge in macaques.
This study identifies a novel autosomal dominant genetic disorder characterized by common variable immunodeficiency and recurrent viral infections caused by a damaging heterozygous CDC45 variant, where allelic expression bias explains the variable clinical severity and NK cell dysfunction observed in affected individuals.
This study identifies the long non-coding RNA Dreg1 as a Tcf1-dependent regulator essential for fine-tuning Gata3 expression to ensure the optimal development of group 2 innate lymphoid cells (ILC2) while leaving other lymphoid lineages unaffected.
This study identifies the heterotrimeric G-protein subunit Gα13 as an essential regulator of intestinal intraepithelial lymphocyte (IEL) migration, positioning, and survival via the Arhgef1/TGFβ axis, revealing that its deficiency leads to IEL loss and increased susceptibility to colitis and colorectal tumors.
This study reveals that reducing Cbfb2 gene dosage in adult hematopoietic progenitors unlocks fetal-like developmental potential, enabling the robust generation of IL-17-producing γδ T cells through a mechanism involving quantitative tuning of RUNX:CBFβ activity and Notch1 signaling.
This study demonstrates that a 6-hour stimulation protocol is superior to an 18-hour protocol for clinical NK cell degranulation (CD107a) assays, offering higher sensitivity and specificity while avoiding the reduced expression observed with longer incubation times.
This study utilizes peptidome analysis of Western blots to identify natural bispecific antibody-bound B-cell epitopes from diverse *Corynebacterium* species and bacteriophages, revealing potential cross-reactivity with human mitochondrial ATP synthase that may contribute to psoriasis pathogenesis.
This study reveals that Crat-mediated acetylation of HSC71 at lysine 579 enhances arthropod immunity against *Spiroplasma eriocheiris* by stabilizing HSC71 to suppress apoptosis and weakening its interaction with SOD to promote microbicidal ROS accumulation, a mechanism that can be therapeutically targeted via SIRT1 inhibition.
This study demonstrates that *Salmonella* biofilms contain Z-DNA within curli:DNA complexes that elicit anti-Z-DNA antibody responses in mice, suggesting that diet-modulated bacterial biofilm formation may contribute to the anti-DNA autoimmunity observed in systemic lupus erythematosus.