392 papers
This study demonstrates that Type I interferon signaling drives mucosal inflammation in inflammatory bowel disease by upregulating myeloid cell responses, as evidenced by elevated signatures in human patients and increased disease susceptibility in mice, while postnatal inhibition of this pathway offers protection against colitis.
The authors present ImPaqT, a versatile Golden Gate-based toolkit that streamlines the modular assembly of Tol2 transgenes in zebrafish, enabling rapid generation of complex transgenic lines with a demonstrated focus on immune cell visualization and manipulation.
Using a novel dual-recombinase fate-mapping system called TRACK mice, this study reveals that distinct tissue environments drive organ-specific clonal selection and functional differentiation of CD4+ T cells during influenza infection, ultimately leading to tissue-dependent memory formation and converging antigen specificity over time.
This bibliometric analysis of 1,742 studies published through May 2025 maps the global landscape of clinical metabolomics research on prediabetes and type 2 diabetes, identifying key contributors, leading journals, and emerging hotspots such as gut microbiota and lipidomics to guide future early diagnosis and precision interventions.
This study demonstrates that introducing a natural, farm-like environment to laboratory mice ("indoor rewilding") reshapes systemic and brain immunity, specifically driving microglia toward homeostatic, amyloid-clearing states that better mimic human Alzheimer's disease pathology and improve the translational relevance of neurodegenerative research.
This study demonstrates that allergen immunotherapy-induced mast cell desensitization is an active cellular reprogramming process characterized by allergen-specific IgE internalization, selective signaling uncoupling, and the activation of a distinct immunoregulatory transcriptional program that enhances T cell proliferation, rather than merely representing passive signal attenuation.
This study demonstrates that polyamidoamine dendrimer-functionalized nanomaterials can therapeutically target periodontitis and atherosclerotic comorbidities by capturing cell-free DNA to inhibit inflammatory macrophage transformation and alleviate systemic inflammation.
This study develops a pan-allelic bispecific T cell engager (BiTE) that targets an MPO-derived peptide's N-terminal overhang presented promiscuously by HLA class II molecules, enabling potent and selective killing of acute myeloid leukemia cells while sparing normal myeloid cells.
This study reveals that a spatially encoded crosstalk between Type I and Type II interferons restricts the expansion of progenitor exhausted CD8 T cells during chronic infection by sequestering them in PDL1-rich B cell niches and enforcing checkpoint control, thereby balancing proliferation with the preservation of effector potential.
This study identifies and characterizes a novel MIF-2/CCL20 complex in liver fibrosis, demonstrating that their interaction inhibits MIF-2's tautomerase activity and modulates immune and stromal responses to potentially regulate disease progression.
This study demonstrates that a novel mRNA vaccine (G1-C) incorporating new T cell epitopes and a membrane epitope significantly enhances B and T cell responses, modulates bone marrow hematopoietic stem cell differentiation to boost lymphoid-myeloid immunity, and provides robust in vivo protection against SARS-CoV-2.
This study demonstrates that limited bone marrow chimerism in {gamma}c-deficient mice disrupts thymic cell competition, leading to thymus autonomy and the development of T cell acute lymphoblastic leukemia, thereby highlighting the critical need for robust hematopoietic reconstitution to prevent leukemogenesis during immunodeficiency treatment.
This study utilizes single-nucleus multiomic analysis to characterize the molecular heterogeneity of thymic adipocytes, revealing two distinct subpopulations with beige/brown and white adipose signatures, the latter of which likely originates from thymic epithelial cells under hypoxic conditions and exhibits unique features like antigen presentation.
This study utilizes quantitative proteomics in a murine model to demonstrate that chronic *Pseudomonas aeruginosa* infection drives cochlear injury through immunometabolic remodeling and macrophage-mediated inflammation, leading to oxidative stress and disrupted ion homeostasis.
By mapping the structural epitope landscape of pneumolysin and identifying a conserved, cross-species neutralizing epitope shared among cholesterol-dependent cytolysins, this study provides a foundation for rational, protein-based vaccine design against *Streptococcus pneumoniae* and related pathogens.
This study reveals that common γ-chain cytokines (IL-2 and IL-7) induce a precursor-like, epigenomically plastic KIT+ ILC2 state via STAT5 activation, which retains hybrid features of immature progenitors and is enriched with genetic risk variants for asthma and autoimmunity.
This study utilizes single-cell RNA sequencing and flow cytometry to characterize the distinct immunological profile of drug-free SLE remission, revealing a partial "reset" from active disease marked by reduced activation and interferon signaling, yet persistent TNF signaling and restored regulatory mechanisms in autoreactive B cells that suggest new therapeutic targets for sustaining remission.
This study demonstrates that MUC4-targeted CAR-T cells effectively eliminate chemotherapy-resistant colorectal cancer cells and inhibit tumor growth in aggressive mouse models without causing off-target toxicity, establishing MUC4 as a promising therapeutic target for patients with chemoresistant and invasive disease.
This study identifies a subset of TIM-4-expressing B cells that, through IL-23R signaling and RORγt expression, produce proinflammatory cytokines like IL-17A to drive autoimmunity and allograft rejection while simultaneously inhibiting their own conversion into regulatory B cells.
This study demonstrates that both migratory type 1 and type 2 conventional dendritic cells are non-redundant, essential mediators of intestinal immune tolerance, as they cooperatively utilize integrin αvβ8 to activate TGF-β and induce regulatory T cells, thereby preventing spontaneous colitis.