392 papers
The study introduces TRACE, a robust, open-source single-cell RNA sequencing classifier that accurately identifies tumor-reactive CD8+ T cells across diverse solid tumors without requiring dataset-specific training, thereby enabling the characterization of anti-tumor immune responses and their correlation with immunotherapy outcomes.
This study demonstrates that during *Trypanosoma cruzi* infection, follicular cytotoxic CD8+ T cells (Tfc) are not a homogeneous population but instead adopt distinct, tissue-specific transcriptional, metabolic, and functional states, with splenic Tfc cells exhibiting enhanced cytotoxicity and glycolysis while lymph node Tfc cells display memory-associated features and greater persistence.
This study demonstrates that pharmacological inhibition of PTPN1/2 using the inhibitor AC484 enhances alveolar macrophage-mediated control of lung metastasis by amplifying the IFN{gamma}-STAT1 signaling pathway, thereby reactivating tissue-resident innate immunity to suppress tumor progression.
Nonpolar metabolites derived from the helminth *Heligmosomoides polygyrus bakeri* reprogram dendritic cells into a tolerogenic phenotype through metabolic and transcriptional changes, thereby attenuating intestinal inflammation when transferred into mice.
This study reveals that DNA-PKcs directly binds to cyclic dinucleotides to inhibit STING-mediated type I interferon responses, establishing a novel regulatory mechanism with significant implications for developing STING-targeting therapeutics.
This study reveals that NOD2 deficiency disrupts intestinal homeostasis by dysregulating estrogen-response genes, establishing a NOD2-estrogen regulatory axis that explains sex-specific aspects of Crohn's disease and suggests hormonal signaling as a potential therapeutic target.
This study reveals that TREM2+ lipid-laden macrophages accumulate in human pulmonary tuberculosis alveoli, creating a permissive niche for bacterial growth through PDIM-induced metabolic reprogramming that contrasts with the protective immunity of adjacent granulomas but can be reversed by vitamin D.
This study demonstrates that mast cells serve as a reservoir for NLRP1 in human skin and that in Multiple Self-Healing Palmoplantar Carcinoma, mutant NLRP1 accumulates in these cells, leading to their overpopulation, epidermal infiltration, and degranulation, which releases inflammasome components and drives the disease pathology.
This study demonstrates that the host protease TMPRSS2 impairs antibody recognition of the SARS-CoV-2 spike protein by inducing partial S1 shedding and conformational changes in the S2 subunit, thereby promoting a fusion-intermediate state that is less accessible to humoral immune responses.
This study utilizes longitudinal spatial profiling to demonstrate that adoptive T cell therapy in murine melanoma induces distinct neutrophil infiltration patterns and compartmentalization between tumor-draining and non-tumor-draining lymph nodes, where enhanced innate immune signaling drives neutrophil accumulation that may differentially impact CD8+ T cell expansion.
This study reveals that lung cancer drives emergency myelopoiesis in the bone marrow by expanding S100A9+ and LCN2+ hematopoietic stem and progenitor cells, where S100A9 acts as an upstream regulator of LCN2 and represents a promising therapeutic target to inhibit tumor growth and overcome immunotherapy resistance.
This paper presents a biophysical model demonstrating that the presence of Fc{gamma} receptors on follicular dendritic cells acts as a regulatory mechanism to balance the affinity and diversity of germinal-center B cells during antibody maturation.
This study demonstrates that both gestational age and mode of delivery significantly shape neonatal CD4+ T cell development, with prematurity driving heightened inflammatory responsiveness and natural birth inducing an immune activation signature, whereas cesarean section is associated with a more restrained functional profile.
By integrating transcriptomics, drug perturbation data, and translational immunology, this study identifies sirolimus, pioglitazone, and fulvestrant as novel precision therapeutics that reverse the disease signature and suppress inflammation in hidradenitis suppurativa.
Despite exhibiting elevated baseline inflammation, individuals with alcohol use disorder show interleukin-6 responses to acute stress that are comparable to healthy controls, although the study highlights that blood collection methods significantly influence IL-6 measurements.
This study reveals that the gut microbiome's capacity to drive autoimmune neuroinflammation in multiple sclerosis is dynamic and most potent during the early stages of the disease, suggesting that microbiome-based therapeutic interventions should target a limited early therapeutic window.
This paper presents a semi-automated, high-throughput immunopeptidomics platform that combines optimized 96-well processing with advanced mass spectrometry to achieve ultrasensitive detection of MHC peptides from low-input samples, enabling robust biological discovery in scenarios where cell numbers are limited.
This study identifies IκBζ as a critical molecular switch that reprograms regulatory T cells into Th2-like effectors by modulating BATF expression, thereby driving systemic type 2 inflammation and disrupting peripheral immune tolerance.
This study identifies a TIM-3-STAT3-IL-35 signaling axis in dendritic cells as a critical driver of immunosuppression and disease progression in visceral leishmaniasis, demonstrating that inhibiting STAT3 restores protective immunity and reduces parasite burden.
This study demonstrates that while commercial vaccines (Clynav and AlphaJect Micro 1-PD) effectively reduce Salmonid alphavirus subtype 3 shedding in individually housed Atlantic salmon, concurrent bacterial co-infection with *Tenacibaculum dicentrarchi* alters the vaccine's impact on shedding duration and cumulative release.