212 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study demonstrates that a 6-hour stimulation protocol is superior to an 18-hour protocol for clinical NK cell degranulation (CD107a) assays, offering higher sensitivity and specificity while avoiding the reduced expression observed with longer incubation times.
This study utilizes peptidome analysis of Western blots to identify natural bispecific antibody-bound B-cell epitopes from diverse *Corynebacterium* species and bacteriophages, revealing potential cross-reactivity with human mitochondrial ATP synthase that may contribute to psoriasis pathogenesis.
This cross-sectional study conducted in Gabon reveals that individuals with microfilaremic loiasis exhibit significantly reduced SARS-CoV-2-specific T cell (IFN-γ) responses compared to those with occult loiasis or no infection, while antibody levels remain unaffected.
This study reveals that Crat-mediated acetylation of HSC71 at lysine 579 enhances arthropod immunity against *Spiroplasma eriocheiris* by stabilizing HSC71 to suppress apoptosis and weakening its interaction with SOD to promote microbicidal ROS accumulation, a mechanism that can be therapeutically targeted via SIRT1 inhibition.
This study demonstrates that *Salmonella* biofilms contain Z-DNA within curli:DNA complexes that elicit anti-Z-DNA antibody responses in mice, suggesting that diet-modulated bacterial biofilm formation may contribute to the anti-DNA autoimmunity observed in systemic lupus erythematosus.
This study characterizes vaccine-induced SARS-CoV-2 antibodies, revealing that while those targeting immunodominant spike regions are potent but susceptible to viral escape, those binding a conserved N-terminal domain hydrophobic pocket exhibit broader neutralization breadth against emerging variants.
This bibliometric analysis of 1,742 studies published through May 2025 maps the global landscape of clinical metabolomics research on prediabetes and type 2 diabetes, identifying key contributors, leading journals, and emerging hotspots such as gut microbiota and lipidomics to guide future early diagnosis and precision interventions.
This study demonstrates that decidual macrophages in early-onset preeclampsia exhibit impaired efferocytosis and phagocytosis due to a failure to upregulate scavenger receptors, leading to the accumulation of apoptotic trophoblasts and a shift toward a pro-inflammatory phenotype characterized by increased CXCL-8 and IL-6 release.
This paper introduces CALM, a contrastive learning-based dual-encoder architecture that treats antibody-antigen recognition as molecular translation to enable bidirectional sequence-to-specificity prediction, achieving a 7% top-1 retrieval rate on a rigorous, leakage-controlled test set.
This study demonstrates that during *Trypanosoma cruzi* infection, follicular cytotoxic CD8+ T cells (Tfc) are not a homogeneous population but instead adopt distinct, tissue-specific transcriptional, metabolic, and functional states, with splenic Tfc cells exhibiting enhanced cytotoxicity and glycolysis while lymph node Tfc cells display memory-associated features and greater persistence.