212 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study reveals that lung cancer drives emergency myelopoiesis in the bone marrow by expanding S100A9+ and LCN2+ hematopoietic stem and progenitor cells, where S100A9 acts as an upstream regulator of LCN2 and represents a promising therapeutic target to inhibit tumor growth and overcome immunotherapy resistance.
This paper presents a biophysical model demonstrating that the presence of Fc{gamma} receptors on follicular dendritic cells acts as a regulatory mechanism to balance the affinity and diversity of germinal-center B cells during antibody maturation.
This study reveals that the gut microbiome's capacity to drive autoimmune neuroinflammation in multiple sclerosis is dynamic and most potent during the early stages of the disease, suggesting that microbiome-based therapeutic interventions should target a limited early therapeutic window.
This study elucidates the structural and biochemical mechanisms by which the promiscuous chicken MHC class I molecule BF2*21:01 balances a broad peptide repertoire with specific stability preferences, revealing simplifying principles that govern its anchor residue co-variation and offer a foundation for predicting pathogen peptides.
VDJdive and ECLIPSE are computational methods that utilize an expectation-maximization algorithm to resolve ambiguous clonotypes in single-cell TCR sequencing data caused by chain dropouts or artifacts, thereby enhancing clone size accuracy and improving the tracking of T cell clones across biological conditions.
This study reveals that homotypic SLAMF1:SLAMF1 interactions between innate T cells and neutrophils trigger the release of soluble factors that activate neutrophils to effectively kill the fungal pathogen *Blastomyces dermatitidis*.
This study utilizes spatial transcriptomics to demonstrate that the CCL19-CCR7 axis is a key mediator of T cell recruitment in the leishmanin skin test, providing critical biomarkers to support the development and deployment of leishmanin antigens for disease surveillance and vaccine efficacy assessment.
This study utilizes a genetic knockout mouse model and spatial transcriptomics to demonstrate that host- and tumor-derived Osteopontin play distinct yet cooperative roles in colorectal cancer liver metastasis by driving tumor proliferation, modulating macrophage polarization, and suppressing T cells, thereby identifying OPN blockade as a promising therapeutic strategy.
This study reveals that the cytokine IL-22 acts as a critical proviral factor for gammaherpesviruses by promoting germinal center expansion and polyclonal autoimmunity, thereby facilitating the establishment of lifelong viral latency and pathogenesis.
This study reveals that the natural killer cell receptor KIR2DL4 utilizes an allosteric disulfide switch between Cys10-Cys28 and Cys28-Cys74 configurations, regulated by protein disulfide isomerase, to control its transition from an inactive state to an HLA-G-binding form that triggers endocytosis and supports placental development.