392 papers
This study reveals that the cytokine IL-22 acts as a critical proviral factor for gammaherpesviruses by promoting germinal center expansion and polyclonal autoimmunity, thereby facilitating the establishment of lifelong viral latency and pathogenesis.
This study demonstrates that TLR-mediated B cell activation requires metabolic reprogramming characterized by upregulated amino acid uptake via SLC7A5 and increased cholesterol biosynthesis to drive proliferation.
This study reveals that red blood cell transfusion acts as a non-canonical immune stimulus that induces suboptimal CD4+ T cell help, resulting in limited IgG class switching compared to the robust response elicited by vaccination.
This study demonstrates that the IRE1α-XBP1 axis is essential for IgE-dependent mast cell activation and allergic responses, as its inhibition or knockdown significantly suppresses degranulation, cytokine release, and anaphylaxis, highlighting it as a promising therapeutic target for allergic diseases.
This study demonstrates the feasibility and biological value of a novel workflow that combines Xenium in situ spatial transcriptomics and Imaging Mass Cytometry on a single FFPE tissue section, revealing that while global RNA-protein correlations exist, integrating both modalities at the single-cell level yields the most comprehensive and biologically meaningful insights into cellular landscapes.
This study reveals that SNAP23 and SNAP25 play opposing roles in MR1-mediated antigen presentation to MAIT cells, where SNAP23 facilitates the trafficking and presentation of microbial antigens while SNAP25 suppresses this process.
This study reveals that the natural killer cell receptor KIR2DL4 utilizes an allosteric disulfide switch between Cys10-Cys28 and Cys28-Cys74 configurations, regulated by protein disulfide isomerase, to control its transition from an inactive state to an HLA-G-binding form that triggers endocytosis and supports placental development.
This study characterizes a distinct, stable, and cytotoxic CD8+ T-cell signature in rheumatoid arthritis patients targeting HLA class I-restricted autoantigens, revealing how citrullination modulates antigen recognition and supporting a direct pathogenic role for these cells in the disease.
This study utilizes an integrated in-silico workflow combining immunoinformatics and structural modeling to design and evaluate RasIC-01v, a multi-epitope vaccine candidate targeting the overexpressed Podoplanin antigen as a potential therapeutic strategy for Glioblastoma Multiforme.
This study identifies endothelial PTBP1 as a critical regulator of cardiac allograft vasculopathy, demonstrating that its deletion preserves mitochondrial function and suppresses fibrotic and immune responses to limit chronic graft injury.
This study addresses the lack of tools for studying *Clostridioides difficile* immunity by developing and characterizing a novel MHC-II tetramer targeting the immunodominant TcdB1961-1975 epitope, which successfully enables the detection and phenotyping of toxin-specific CD4+ T cells, including T follicular helper cells, following various immunization strategies.
This study identifies the buried S2 apex of the SARS-CoV-2 spike protein as an immunodominant epitope that elicits a highly expanded, non-neutralizing public antibody response restricted to the IGHV3-30 germline, thereby highlighting a major obstacle for universal coronavirus vaccine development and the need for precision antigen design to redirect immunity toward more potent neutralizing targets.
This study demonstrates that the membrane repair protein MG53 protects against intestinal inflammation by physically interacting with and inhibiting NLRP3 inflammasome activation, thereby mitigating the severity of colitis.
The paper introduces TCRPPO2, an AI-driven framework combining reinforcement learning and generative AI to optimize T cell receptor affinity for tumor antigens, successfully engineering high-activity candidates for the MART-1 antigen that were experimentally validated in functional assays.
By integrating multi-omics data with deep learning, this study reveals that tissue-resident alveolar macrophages exhibit more restrained inflammatory responses than recruited monocytes due to a stabilizing gene regulatory network architecture centered on PU.1 and CEBP{beta}.
Using the Four Core Genotypes mouse model, this study demonstrates that gonadal sex is the primary driver of quantitative differences in peripheral T and B cell subpopulations, while also revealing specific effects of the Sry transgene and Y chromosome on thymic development and marginal zone B cells.
This study demonstrates that lung-innervating sympathetic neurons, activated by sensory input during *Streptococcus pneumoniae* infection, release norepinephrine to synergistically stimulate T cell interferon- production and B cell antibody responses, thereby coordinating an adaptive immune defense that reduces bacterial burden.
This study demonstrates that combining radiation therapy with BET inhibition synergistically induces robust, CD8+ T cell-dependent systemic anti-tumor immunity and long-term immunological memory in immunologically cold breast cancer and soft tissue sarcoma models by enhancing immunogenic cell death and blocking PD-L1 upregulation.
This study utilizes integrated single-cell multiomic profiling and functional validation to demonstrate that human B cells follow distinct differentiation routes to form plasma cells, with germinal center-independent pathways involving a transient MEF2C-driven CD30+ intermediate leading to CD44v9+ plasma cells, while germinal center-dependent pathways bypass this intermediate to generate CD44v9-negative plasma cells.
This study reveals that locally produced C3 by lung epithelial cells, rather than circulating liver-derived C3, is essential for initiating early neutrophil recruitment during bacterial pneumonia by activating both canonical and non-canonical chemotactic pathways.