392 papers
This study demonstrates that the Golgi-localized GTPase GBP5 is essential for maintaining Golgi integrity and driving glycolytic flux, glucose uptake, and cytokine production in IFN-γ-stimulated macrophages, thereby playing a critical role in immunometabolism.
This study overcomes technical limitations to characterize immediate transcriptional changes in T cells and cancer cells upon direct physical contact using image-enabled cell sorting, revealing dynamic gene expression signatures that link specific TCR-peptide interactions to distinct tumor-infiltrating T cell subsets and enabling the future identification of effective cytotoxic T cell receptors in vivo.
This study demonstrates that in human challenge models of Dengue virus infection, the transcriptional response and clinical symptomatology are primarily driven by viral burden (RNAemia) rather than serotype, revealing a conserved core antiviral response alongside unique signatures linked to high viral loads.
This study identifies immunodominant epitopes from seed storage proteins, particularly the C-terminus of maize alpha-zein, as key targets for intestinal regulatory T cells that develop during weaning and play a crucial role in suppressing systemic immune responses to dietary antigens.
This study demonstrates that MET-targeting nanobody (VHH)-based CAR T cells exhibit low tonic signaling, favorable cytokine profiles, and potent therapeutic efficacy against MET-overexpressing solid tumors, particularly in a metastatic triple-negative breast cancer model, offering a promising new strategy for solid tumor immunotherapy.
This study introduces an automated multi-parameter molecular dynamics framework to evaluate the structural and dynamic similarities between Klebsiella pneumoniae-derived peptides and a human self-peptide bound to HLA-B27, successfully identifying KP1 as a potential molecular mimic while distinguishing it from less stable candidates KP2 and KP3.
This study identifies the protein GIV as a critical molecular brake that suppresses macrophage cholesterol efflux by trapping the transporter ABCA1 and inhibiting cAMP signaling, demonstrating that genetic or pharmacologic disruption of this GIV-Gi checkpoint restores reverse cholesterol transport and effectively reverses atherosclerotic plaque burden in models where current therapies fail.
This study identifies a previously uncharacterized intracellular, hypoglycosylated, low-molecular-weight form of ADA2 localized to lysosomes, the absence of which in macrophages serves as a specific cellular biomarker for DADA2 and correlates with reduced enzymatic activity and variant pathogenicity.
This study demonstrates that ThINKK-induced NK cell cytotoxicity against childhood acute lymphoblastic leukemia is driven by a dual TRAIL-mediated mechanism involving both NK cell activation and direct tumor apoptosis via TRAIL-R1/R2, establishing TRAIL receptor expression as a robust biomarker for patient stratification.
This study reveals that the rapid recall ability of memory CD4+ T cells is driven by memory-specific AP-1 recruitment to regulatory elements, a process facilitated by enhanced chromatin accessibility and reduced DNA methylation that likely modulates co-factor binding, thereby linking epigenetic regulation to both protective immunity and autoimmune disease risk.
This study demonstrates that SATB1 ablation in human T cells disrupts Treg suppressive function while enhancing CD4 CAR T cell-mediated tumor clearance through dysregulated JAK-STAT signaling and cytokine production, suggesting SATB1 modulation as a promising strategy to improve CAR T cell therapy efficacy.
This study demonstrates that prolonged paraformaldehyde fixation significantly impairs the detection of macrophage surface markers in epithelial tissues across multiple organs, whereas shortening the fixation duration preserves both macrophage visualization and tissue architecture for accurate immunofluorescent analysis.