🛡️ Category

immunology

258 papers

Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.

On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.

Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.

🛡️ immunology

Hemoperfusion of pigs with a carbon-cellulose cartridge: a pilot study revealing a new animal model of extended anaphylactic shock

This pilot study establishes a new porcine model of irreversible anaphylactic shock by demonstrating that hemoperfusion with a carbon-cellulose cartridge (Adsorba® 300C) triggers a fatal, complement-mediated pseudoallergic reaction characterized by profound hemodynamic collapse, thereby providing a clinically relevant system to investigate extracorporeal circulation-induced immune responses.

Barta, B. A., Radovits, T., Spiesshofera, S., Husznai, A. J., Dobos, A. B., Meszaros, L., Meszaros, T., Kozma, G. T., Fa (…)2026-03-09
🛡️ immunology

Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles

This study demonstrates that displaying the *E. coli* FimH antigen on I53-50 nanoparticles significantly enhances its immunogenicity, eliciting robust receptor-blocking antibodies in mice and non-human primates comparable to high-dose monomeric formulations, thereby validating a promising nanoparticle-based vaccine strategy for preventing urinary tract infections.

Cole, R. S., Silmon de Monerri, N. C., Lypowy, J., Ponce, C., Kobylarz, C., Liu, L., Kasbo, Z., Kepl, E., Ciolino, T., I (…)2026-03-09
🛡️ immunology

Temporally overlapping mechanisms diversify clonal B cell responses in vivo.

This study reveals that during *Plasmodium* infection, multiple temporally overlapping mechanisms—including Myc-driven expansion, early class switch recombination, and germinal center-mediated somatic hypermutation—combinatorially diversify individual B cell clones to amplify and safeguard humoral immunity, while anti-malarial treatment limits the magnitude but not the rate of this diversification.

Skinner, O. P., Asad, S., Moreira, M. L., Lee, H. J., Williams, C. G., Ruan, Z., Lim, J., Kerr, A. S., Li, S., Zhu, C. (…)2026-03-06
🛡️ immunology

GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohns disease

This study demonstrates that GM-CSF acts as a critical spatial regulator in Crohn's disease by mediating myeloid-lymphoid crosstalk to restrain ILC1 expansion, sustain ILC3 maintenance, and promote IL-22 production, thereby limiting epithelial injury and inflammation in ulcerated intestinal regions.

Morrison, J. K., Sabic, K., Maskey, N., Talware, S., Hsu, N.-y., Chasteau, C., Aslinger, E., Herb, J. T., Nayar, S., Lev (…)2026-03-06
🛡️ immunology

Evaluating 6- and 18-hour stimulation durations for natural killer cell degranulation (CD107a assay) to optimize workflow efficiency in a clinical immunology laboratory

This study demonstrates that a 6-hour stimulation protocol is superior to an 18-hour protocol for clinical NK cell degranulation (CD107a) assays, offering higher sensitivity and specificity while avoiding the reduced expression observed with longer incubation times.

Feehan, L., Koutoufaris, L., Dorsey, J., Paessler, M., Pandey, P.2026-03-04
🛡️ immunology

Peptidome Analysis of Western Blots Identifies Natural Bispecific Antibody-Bound Corynebacterium and Phage B-cell Epitopes with Potential Relevance to Psoriasis

This study utilizes peptidome analysis of Western blots to identify natural bispecific antibody-bound B-cell epitopes from diverse *Corynebacterium* species and bacteriophages, revealing potential cross-reactivity with human mitochondrial ATP synthase that may contribute to psoriasis pathogenesis.

Schroeder, J. M.2026-03-04
🛡️ immunology

Microfilaremic loiasis is associated with T cell hyporesponsiveness against SARS CoV-2

This cross-sectional study conducted in Gabon reveals that individuals with microfilaremic loiasis exhibit significantly reduced SARS-CoV-2-specific T cell (IFN-γ) responses compared to those with occult loiasis or no infection, while antibody levels remain unaffected.

Auge-Stock, M., Okwu, D. G., More, A., Doralt, A., Bikangui, R., Boussoukou, I. P. M., Eberhardt, K. A., Sandkuhl, M., Z (…)2026-03-04