258 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study elucidates the structural and biochemical mechanisms by which the promiscuous chicken MHC class I molecule BF2*21:01 balances a broad peptide repertoire with specific stability preferences, revealing simplifying principles that govern its anchor residue co-variation and offer a foundation for predicting pathogen peptides.
VDJdive and ECLIPSE are computational methods that utilize an expectation-maximization algorithm to resolve ambiguous clonotypes in single-cell TCR sequencing data caused by chain dropouts or artifacts, thereby enhancing clone size accuracy and improving the tracking of T cell clones across biological conditions.
This study reveals that homotypic SLAMF1:SLAMF1 interactions between innate T cells and neutrophils trigger the release of soluble factors that activate neutrophils to effectively kill the fungal pathogen *Blastomyces dermatitidis*.
This study utilizes spatial transcriptomics to demonstrate that the CCL19-CCR7 axis is a key mediator of T cell recruitment in the leishmanin skin test, providing critical biomarkers to support the development and deployment of leishmanin antigens for disease surveillance and vaccine efficacy assessment.
This study utilizes a genetic knockout mouse model and spatial transcriptomics to demonstrate that host- and tumor-derived Osteopontin play distinct yet cooperative roles in colorectal cancer liver metastasis by driving tumor proliferation, modulating macrophage polarization, and suppressing T cells, thereby identifying OPN blockade as a promising therapeutic strategy.
This study reveals that the cytokine IL-22 acts as a critical proviral factor for gammaherpesviruses by promoting germinal center expansion and polyclonal autoimmunity, thereby facilitating the establishment of lifelong viral latency and pathogenesis.
This study reveals that the natural killer cell receptor KIR2DL4 utilizes an allosteric disulfide switch between Cys10-Cys28 and Cys28-Cys74 configurations, regulated by protein disulfide isomerase, to control its transition from an inactive state to an HLA-G-binding form that triggers endocytosis and supports placental development.
This study identifies endothelial PTBP1 as a critical regulator of cardiac allograft vasculopathy, demonstrating that its deletion preserves mitochondrial function and suppresses fibrotic and immune responses to limit chronic graft injury.
This study identifies the buried S2 apex of the SARS-CoV-2 spike protein as an immunodominant epitope that elicits a highly expanded, non-neutralizing public antibody response restricted to the IGHV3-30 germline, thereby highlighting a major obstacle for universal coronavirus vaccine development and the need for precision antigen design to redirect immunity toward more potent neutralizing targets.
By integrating multi-omics data with deep learning, this study reveals that tissue-resident alveolar macrophages exhibit more restrained inflammatory responses than recruited monocytes due to a stabilizing gene regulatory network architecture centered on PU.1 and CEBP{beta}.