7905 papers
This pharmacovigilance study of over 2,400 FAERS reports reveals that lenvatinib treatment in thyroid cancer patients is associated with significant vascular, renal, and cardiac risks, identifies seven novel adverse events not listed on the FDA label, and uncovers a biphasic time-to-onset pattern that supports stratified clinical monitoring.
This sequential cohort study demonstrates that an AI-enhanced case-based learning model significantly improves medical students' pathophysiology examination scores and clinical reasoning skills, though it also highlights the need to mitigate over-reliance on AI to preserve critical thinking depth.
This retrospective cohort study of 433 patients with cT1N0M0 papillary thyroid carcinoma suggests that while BRAF V600E positivity is associated with a higher risk of structural recurrence after radiofrequency ablation, it should not serve as an absolute exclusion criterion but rather as a factor to guide patient counseling and follow-up intensity.
This cross-sectional study of over 67,000 older adults in Japan utilizes association rule mining and network analysis to reveal that while polypharmacy is prevalent, the risk of severe drug–drug interactions rises significantly with medication count, underscoring the need for medication reviews that consider prescription patterns and network centrality.
This study projects that South Korea's Integrated Nursing and Care Service will impose a fiscal burden exceeding National Health Insurance revenue between 2038 and 2046 by 2050, driven by user base and bed expansion rather than increased per-user utilization, thereby highlighting an urgent need to align benefit growth with post-acute care and payment reforms for long-term sustainability.
This prospective randomized controlled trial demonstrates that inferior vena-cava collapsibility index (IVC-CI)-guided fluid management significantly reduces the time-weighted average and severity of spinal anesthesia-induced hypotension in women undergoing elective cesarean delivery compared to fixed-rate fluid administration.
This randomized controlled trial demonstrates that pretreating women with endometriosis-associated infertility with dienogest for 3–6 months prior to their first ICSI cycle significantly improves oocyte maturation, fertilization rates, embryo quality, and both biochemical and clinical pregnancy outcomes compared to direct ICSI without hormonal pretreatment.
This study presents the development and computational validation of PC-NAKI, a novel maternal-enhanced risk stratification tool for neonatal acute kidney injury that demonstrated promising discrimination and calibration in a synthetic cohort, establishing a framework for future real-world clinical validation.
This cross-sectional study of children and adolescents with Angelman syndrome found that while caregiver-rated communicative competence varies significantly by genotype, epilepsy status, and age, it is not associated with behavioral difficulties or caregiver burden.
This systematic review and meta-analysis of six randomized controlled trials suggests that oral probiotic supplementation may yield modest improvements in global cognition and specific domains for adults with mild cognitive impairment, though the clinical relevance remains uncertain and further large-scale, strain-specific research is needed.