3079 papers
This study characterizes the clinical and molecular spectrum of FBXO11-related neurodevelopmental disorder through the analysis of 21 patients, identifying mild intellectual disability, behavioral dysregulation, and subtle facial dysmorphism as core features while proposing structured diagnostic criteria to improve recognition of the condition.
This case series from a tuberculosis-endemic region in South India demonstrates that surgical resection, often preceded by endovascular embolization for life-threatening hemorrhage, provides a definitive and effective treatment for pulmonary aspergilloma causing recurrent hemoptysis in post-tuberculous patients with acceptable morbidity.
This study identifies the conserved His41 site of coronavirus 3CLpro as a novel non-covalent pan-binding target, leading to the development of the optimized derivative ISL-221, which demonstrates broad-spectrum antiviral efficacy against multiple coronaviruses comparable to Paxlovid.
This study demonstrates that increased myocardial [⁶⁴Cu]Cu-DOTATATE uptake detected by PET/MR in rats serves as an early biomarker for doxorubicin-induced cardiac dysfunction, correlating with subsequent declines in left ventricular ejection fraction.
This prospective UK birth cohort study of first-time mothers found that experiencing psychological intimate partner violence during pregnancy, regardless of whether it was perpetrated by the partner or the mother, significantly increases the likelihood of not exclusively breastfeeding at six weeks postpartum, whereas physical violence showed no such association.
This study demonstrates that riociguat treatment in a rat model of ovarian ischemia–reperfusion injury significantly mitigates tissue damage by reducing oxidative stress and inflammation, enhancing antioxidant capacity, and improving endocrine function, likely through the modulation of the NO–sGC–cGMP pathway.
This study of 979 Czech adolescents reveals that adherence to 24-hour movement guidelines, particularly regarding screen time, physical activity, and sleep, is significantly associated with improved health-related quality of life and wellbeing, with the greatest benefits observed among those meeting all guidelines.
This study characterizes the phenotypic and genotypic profiles of ESβL-producing Gram-negative uropathogens from catheterized patients in Sulaymaniyah, Iraq, revealing a 32% prevalence dominated by *E. coli* carrying high rates of *bla*<sub>TEM</sub> and *bla*<sub>CTX-M</sub> genes, which underscores the urgent need for enhanced antimicrobial stewardship and updated treatment guidelines.
This single-center retrospective study demonstrates that an interventional center-led, risk-score-guided nursing pathway significantly improves perioperative outcomes, including reduced blood pressure fluctuations, faster recovery, and enhanced self-care and medication adherence, for patients with resistant hypertension undergoing laparoscopic renal denervation.
This study analyzing over 180,000 patients demonstrates that common excess-weight metrics misrepresent actual weight loss due to baseline BMI dependence and fail to predict metabolic outcomes after bariatric surgery, suggesting that direct measurement of glycemic response should be prioritized for patients with type 2 diabetes.