📄 medicine

CT-Based Habitat Radiomics and Deep Learning for Predicting Early Response and Survival in Unresectable Hepatocellular Carcinoma Treated with Hepatic Arterial Infusion Chemotherapy plus Lenvatinib and Programmed Death Receptor-1 Inhibitors

This study developed and validated a noninvasive, multidimensional fusion model integrating CT-based habitat radiomics, 2.5D deep learning features, and clinical indicators to accurately predict early treatment response and progression-free survival in patients with unresectable hepatocellular carcinoma receiving HAIC-FOLFOX combined with lenvatinib and PD-1 inhibitors.

Wenyi Bao, Xingyu Chen, Kaidi Long, Minghang Shen, Sensen Li, Chuan Tan, Zhi Chen2026-09-05
📄 medicine

The effect of phase I cardiac rehabilitation exercise training combined with respiratory training on the Improvement of Cardiopulmonary Function: A Randomized Controlled Trial

This randomized controlled trial demonstrates that combining phase I cardiac rehabilitation exercise training with respiratory training significantly improves cardiopulmonary function, specifically increasing VO2 peak, VO2 anaerobic threshold, and O2 pulse, in acute myocardial infarction patients following percutaneous coronary intervention.

Jun-Ting Luo, Ying Feng, Kai-Fang Pang, Jian-Ping Tan, Chun-Mei Zeng, Yan-Mei Zhao2026-09-05
📄 medicine

A High Burden of 10 or More Clinically Asymptomatic Lesions Suppresses Neurocognitive Improvement 6 Months After Endovascular Coiling for Unruptured Intracranial Aneurysms

This study demonstrates that while endovascular coiling for unruptured intracranial aneurysms is generally safe, patients developing 10 or more clinically asymptomatic embolic lesions on post-procedural MRI fail to show the expected 6-month neurocognitive improvements seen in those with fewer lesions.

Hideaki Ono, Kenta Ohara, Satoshi Kiyofuji, Satoshi Koizumi, Yudai Hirano, Takeru Hirata, Takahiro Tsuchiya, Akiya Kawan (…)2026-09-05
📄 medicine

Bridging Borders: Applying the Theoretical Model of Sexual and Reproductive Health Care to Access and Utilisation Experiences of Local and Non-local Hong Kong Residents

This qualitative study of 30 Hong Kong residents, guided by the Theoretical Model of Sexual and Reproductive Health Care, reveals that while educational and clinical services are valued, significant barriers such as privacy concerns, language differences, and scheduling issues—particularly for non-locals—necessitate targeted structural and process reforms to ensure equitable, high-quality sexual and reproductive health care.

Edward Kwabena Ameyaw, Bedru Hussen Mohammed, Vicky Qi Wang, Alice Konja, Padmore Adusei Amoah2026-09-05
📄 medicine

Failure of Cross-Procedure Transportability of Preoperative Prolonged Length-of-Stay Prediction From VATS to Esophagectomy: A Locked Model Evaluation Study

This study demonstrates that preoperative prediction models for prolonged length of stay developed in video-assisted thoracoscopic surgery (VATS) patients fail to transport reliably to esophagectomy patients without modification, exhibiting poor discrimination and significant calibration errors when applied as locked pipelines.

Michael Mosebetsi Moleka, Wanli Jiang2026-09-05
📄 medicine

Bidirectional Longitudinal Association Between Sleep Duration and Knee Osteoarthritis and the Mediating Role of Depressive Symptoms Among Middle-Aged and Older Chinese Adults: A CHARLS Cohort Study

Using data from the China Health and Retirement Longitudinal Study, this research establishes a bidirectional longitudinal association between sleep duration and knee osteoarthritis among Chinese middle-aged and older adults, revealing that shorter sleep increases KOA risk while KOA leads to reduced sleep, with depressive symptoms mediating approximately 17% of this relationship.

Tao Jia, Haile Pan2026-09-05
📄 medicine

Association between glycerin enema use and 14-day unplanned revisits in children with acute viral gastroenteritis: a dual-center retrospective cohort study

This dual-center retrospective cohort study found that administering a glycerin enema within 12 hours of presentation to children with acute viral gastroenteritis was significantly associated with a reduced 14-day unplanned revisit rate, lower antibiotic use, and shorter symptom duration compared to controls, even after propensity score matching and sensitivity analyses.

Liu Shaohua¹, Qiu Jianwu², Li Haohua¹, Jin Tiexia¹, Bao Xiao³, Zuo Yunlong⁴2026-09-05
📄 medicine

Postpartum Haemorrhage and Postpartum Haemoglobin After Vaginal Delivery: A Retrospective Cohort Quantile Regression Analysis

This retrospective cohort study of 1,596 women utilizing quantile regression reveals that postpartum haemorrhage, antepartum anaemia, and the magnitude of haemoglobin decline are the primary heterogeneous determinants of postpartum haemoglobin levels, underscoring the need for integrated, individualized clinical management strategies across the prenatal to postpartum continuum.

Qiuyue Liu, Yongkang Li, Jiayao Li, Jiaxin Wan, Min Xu, Tingting Dai, Cheng Chen2026-09-05
📄 medicine

Knowledge, Attitudes, Behavioural and Social Determinants of Childhood Immunisation Among Caregivers and Healthcare Workers in Sierra Leone: A Convergent Mixed-Methods Study

This convergent mixed-methods study conducted in Sierra Leone reveals that while caregivers generally possess favorable knowledge and attitudes toward childhood immunisation, significant behavioural, social, and health system barriers—such as misinformation, logistical challenges, and resource constraints—continue to hinder optimal vaccine uptake, necessitating strengthened community engagement and health system capacity to improve coverage.

Edwin N Sesay, Amanda Clemens, Nelson Mandela Kargbo, Andrew Kekurah Kemoh, Nella Clemens-Kangbai, Umuhawa Barrie, Marga (…)2026-09-05