📄 Category

medicine

13396 papers

📄 medicine

Clinical Outcomes and Molecular Biomarkers of Response to Pembrolizumab plus Fulvestrant in ER+/HER2− Metastatic Breast Cancer: Results from a Big Ten Cancer Research Consortium Multicenter Phase II Study

In a multicenter Phase II study of ER+/HER2− metastatic breast cancer, the combination of pembrolizumab and fulvestrant demonstrated a manageable safety profile and a 36.4% clinical benefit rate with durable responses in a subset of patients, although these outcomes did not correlate with PD-L1 status.

Nancy Chan, Dirk Moore, Nadia Baka, Kari Wisinski, Jairam Krisnamurthy, Jatin Rana, Pavan Tandra, Douglas Marks, Malinda (…)2026-10-23
📄 medicine

Desaturation Depth Index and Excessive Daytime Sleepiness in Severe Obstructive Sleep Apnea: A Retrospective Polysomnography Study with Exploratory Sex-Stratified Analyses

This retrospective study of 290 patients with severe obstructive sleep apnea demonstrates that the Desaturation Depth Index (DDI), a simple metric derived from mean and nadir oxygen saturation, is independently associated with excessive daytime sleepiness and provides modest, pragmatic incremental value over conventional measures like the apnea–hypopnea index, though it does not significantly differ in performance between sexes.

barış çil, Mehmet Sinan Bodur, Mehmet Kabak2026-10-23
📄 medicine

Early urinary continence recovery after extraperitoneal Retzius-space-sparing robot-assisted radical prostatectomy: a single-center retrospective cohort study

This single-center retrospective cohort study demonstrates that extraperitoneal Retzius-space-sparing robot-assisted radical prostatectomy significantly accelerates early urinary continence recovery at one and three months postoperatively compared to conventional surgery, likely due to the preservation of a longer membranous urethral length.

yuhao zhang, yanli hu, yixin liu, tongxiang diao, qiang fu2026-10-23
📄 medicine

Qualitative and Quantitative Comparison of Infant Brain Mri Quality: Feed and Wrap Technique Versus Sedation - Single Centre Experience

This single-center retrospective study demonstrates that the "feed and wrap" technique is a viable alternative to sedation for infant brain MRI in suspected hypoxic-ischemic encephalopathy, yielding comparable diagnostic quality and quantitative signal metrics in most sequences despite slightly lower performance in 3D-T1 imaging.

Chiara Schiarelli, Francesca Lisi, Giuseppe Varcasia, Tommaso Verdolotti, Amato Infante, Alessandro Perna, Lorenzo Gallo (…)2026-10-23
📄 medicine

Dynamic responses of metabolic rate and heart rate under occupational heat stress

This study characterizes the dynamic metabolic and heart rate responses of workers under varying thermal and clothing conditions, revealing that activity intensity is the primary determinant of physiological strain and establishing new empirical models that challenge existing ISO standards for more accurate heat-strain assessment.

Mengyao Huang, Jia Wang, Ming Fu, Yayun Li, Liangchang Shen, Shifei Shen, Jean-Marie Aerts2026-10-23
📄 medicine

Neuroanatomy of Orthorexia Nervosa: Emerging Insights from Structural Neuroimaging

This study utilizes high-resolution structural MRI to identify distinct neuroanatomical differences in individuals with orthorexia nervosa, specifically finding reduced entorhinal cortex thickness and increased posterior cingulate cortex thickness, which suggests shared neurobiological patterns with obsessive-compulsive disorder and eating disorders despite the need for larger-scale validation.

Emanuele Tinelli, Alessia Maiolo, Antonio Di Renzo, Mario Antonio Muscari, Nicola Tallarico, Umberto Sabatini, Cristina (…)2026-10-23
📄 medicine

APOE ε4 carriage is associated with pallido-putaminal diffusion alterations in early Parkinson’s disease

This study reveals that APOE ε4 carriers with early, drug-naïve Parkinson's disease exhibit specific microstructural alterations in the pallido-putaminal regions compared to non-carriers, suggesting a link between this genetic risk factor and distinct neural changes in the disease's initial stages.

Giovanni Restuccia, Augusto Ielo, Viviana Lo Buono, Angelo Quartarone, Lilla Bonanno2026-10-23
📄 medicine

Diagnostic and Management Practices for Cerebellar Ataxia among Neurologists in India: A Cross-sectional Survey

A 2025 cross-sectional survey of Indian neurologists reveals that while diagnostic practices for cerebellar ataxia align with standard recommendations, significant gaps persist in affordable genetic testing, multidisciplinary rehabilitation, and standardized outcome assessment, highlighting critical areas for improving care and preparing for emerging therapies.

Divyani Garg, Annu Aggarwal, Jacky Ganguly, Divya M Radhakrishnan, Roopa Rajan, Vikram V Holla, Nitish Kamble, Pankaj Ag (…)2026-10-23
📄 medicine

Incidental Discovery of Double Inversion Physiology with a Novel Right Atrial to Left Ventricular Shunt During Workup for Acute Abdominal Pain and Uterine Leiomyomas: A Case Report

This case report describes the incidental discovery of a unique right atrium-to-left ventricle shunt in a 35-year-old woman with complete situs inversus and congenitally corrected transposition of the great arteries, highlighting the critical role of high-resolution CT in identifying complex compensatory pathways in rare congenital heart defects.

Peyman Astaraki, Mohammad Heydarian, Omid Rajabzadeh2026-10-23