7905 papers
Long-term administration of the Mas receptor agonist AVE 0991 attenuates PTZ-induced seizure severity, anxiety, and cognitive impairment in mice by modulating MasR, NR2B, and BDNF mRNA expression, suggesting its potential as a therapeutic strategy for epilepsy.
This cross-sectional study in Chongqing, China, identifies that healthcare workers' self-efficacy in providing breastfeeding guidance is significantly enhanced by higher levels and frequency of family-centered lactation support as well as employment in maternal and child specialist hospitals.
This study, utilizing an explorative survey of 213 nurses in Sampang Regency and integrating Gibson's performance theory with the McKinsey 7S Framework, concludes that while five organizational factors are individually associated with health organization performance, leadership is the sole significant predictor in multivariate analysis.
This study developed and validated a high-performing XGBoost-based predictive model, enhanced with SHAP interpretation and a web-accessible dynamic nomogram, to accurately identify elderly patients with cervical spine conditions at risk for postoperative delirium using five key factors: frailty, nutritional condition, anesthesia time, urea concentration, and sarcopenia.
This case report describes a rare instance of acute intermittent porphyria in a pregnant woman that initially mimicked Gitelman syndrome through persistent hyponatremia and renal electrolyte wasting, which resolved spontaneously after delivery following the identification of a pathogenic HMBS variant.
This single-arm quasi-experimental study conducted at Zahedan University of Medical Sciences found that a short Visual Thinking Strategies-based educational intervention significantly improved medical students' attitudes toward older adults and reduced their ageist attitudes, though the preliminary findings are limited by the absence of a control group.
This study demonstrates that Large Language Models, particularly Gemini, are effective and stable tools for automating Spanish-language HIV epidemiological surveillance tasks, including clinical summarization and risk factor extraction, thereby offering a viable solution to reduce documentation burdens and improve early diagnosis in high-volume emergency settings.
The DECISION project utilized a systematic review, patient interviews, and focus groups to identify and prioritize six patient-informed attributes—effectiveness, treatment frequency, duration, self-management requirements, side effects, and costs—that will serve as the foundation for a discrete choice experiment on spinal manipulative therapy for low back pain in the Netherlands.
Through patient journey mapping of 19 individuals in the Netherlands, this study reveals that communication gaps and discontinuities across the hand and wrist orthopaedic care pathway—rather than individual encounters—significantly shape patient experiences, highlighting the need for improved referrals, expectation management, and inter-provider information exchange.
This prospective cohort study reveals that while clinically relevant post-stroke spasticity affects a majority of patients with persistent motor deficits early after stroke, there is a critical implementation gap where no patients with documented recommendations for botulinum toxin type A therapy actually initiated treatment within a structured follow-up program.