3079 papers
This exploratory cross-sectional study of Angolan medical residents reveals a significant gap between high research intentions and low actual productivity, driven primarily by barriers such as insufficient protected time, mentorship, and methodological training, which underscores the need for institutional reforms to support scholarly output.
This study demonstrates that GUGU decoction accelerates osteoporotic fracture healing in ovariectomized rats by rebalancing bone turnover and activating the Wnt/β-catenin and PI3K/AKT signaling pathways, thereby validating the traditional Chinese medicine principle of "tonifying the kidney and activating blood" for treating bone disorders.
This study developed and validated a practical linear regression model using sex, serum uric acid, serum creatinine, and fasting plasma glucose to accurately predict fractional uric acid excretion in Chinese inpatients with Type 2 Diabetes, offering a convenient alternative to complex 24-hour urine collection methods.
This study of 6,548 occupational health screening participants on the Qinghai–Tibetan Plateau reveals that blood pressure and hypertension prevalence are significantly influenced by both altitude and ethnicity, with Tibetans demonstrating a distinct physiological advantage and stronger protective effects against hypertension at moderate to high altitudes compared to Han individuals.
This study presents a novel, highly stable prefusion trimer-stabilized RSV F recombinant protein vaccine that, when formulated with Al(OH)3, elicits robust immunogenicity and protective immunity against RSV in mice and cotton rats without inducing Th2 polarization or lung inflammation, offering a promising liquid vaccine option for vulnerable populations.
This qualitative study in Sindh, Pakistan, reveals that injured patients face significant unmet mental health needs due to systemic barriers like stigma and limited resources, highlighting the urgent need to integrate culturally appropriate psychological screening and support into injury care pathways.
This qualitative study across six Nigerian states reveals that women's preference for non-institutional births stems from a complex interplay of economic constraints, logistical barriers, and negative facility experiences, underscoring the need for health system reforms that prioritize respectful, affordable, and culturally responsive care to improve maternal outcomes.
A quasi-experimental study conducted at University College Hospital in Ibadan, Nigeria, found that a psychoeducation-based intervention, while highly satisfactory to participants, failed to produce statistically significant improvements in self-esteem, depressive symptoms, or HIV self-stigma among adolescents living with HIV compared to a peer support control group.
This study demonstrates that LARP1 acts as an oncogenic driver in endometrial cancer by promoting tumor growth and carboplatin resistance through E2F1 regulation, suggesting that targeting LARP1 could suppress tumor progression and enhance chemotherapy sensitivity.
This quantitative study demonstrates that dual-layer spectral CT parameters, particularly in the lower lung lobes, can effectively differentiate idiopathic inflammatory myopathy-associated interstitial lung disease subtypes (ASS-ILD vs. PM/DM-ILD) even when they present with identical radiological patterns.