📄 medicine

Platelet-to-Lymphocyte Ratio as a Predictor of Metastasis in Testicular Germ Cell Tumors: Clinicopathological Features from a 10-Year Retrospective Cohort in Tibet

This 10-year retrospective study of 78 patients in Tibet identifies the platelet-to-lymphocyte ratio (PLR) as a simple, cost-effective, and independent predictor of metastasis in testicular germ cell tumors, highlighting its potential for risk stratification in the region.

Hao Yi, Baopeng Zhang, Jiangcun silang, Feng Luo, Yalong Gu, Lei Zheng, Zhiqiang Du, Xinlong Tian, Pai Peng, Feng Wang (…)2026-10-23
📄 medicine

Six-hour landmark prediction of poor subsequent urine output in critically ill adults with heart failure: model development and external validation

This study developed and externally validated a six-hour early-response model to predict poor subsequent urine output in critically ill adults with heart failure, finding that while early-response data improved prediction, complex algorithms offered no advantage over simpler regression models and calibration issues currently limit immediate clinical application.

Xiaohuan Zhuang, Xinyuan Zhang, Tongnian Fang2026-10-23
📄 medicine

Association between patient-perceived and device-recorded continuous positive airway pressure usage discrepancy and sleep restfulness in patients with obstructive sleep apnea receiving continuous positive airway pressure therapy

This study demonstrates that in patients with obstructive sleep apnea, a greater positive discrepancy between subjective and objective CPAP usage duration, alongside shorter subjective sleep latency, is independently associated with higher sleep restfulness, suggesting that clinical assessments should incorporate patients' subjective perceptions of therapy use rather than relying solely on device-recorded data.

Satoshi Hamada, Michiko Tsuchiya, Tsuguru Hatta, Fuyuko Hatta, Nobuhiro Shibata, Yasuhisa Sintani, Hisashi Ooka, Maya To (…)2026-10-23
📄 medicine

Risk factors for postpartum haemorrhage recorded in primary care electronic health records in north eastern Iran: a population-based case control study

This population-based case-control study in north-eastern Iran reveals that while out-of-hospital births and multiple pregnancies are associated with higher odds of postpartum haemorrhage, the low predictive power of primary care electronic health records and significant documentation inconsistencies suggest these data currently reflect recording artifacts rather than true clinical prevalence, necessitating objective blood loss measurement and hospital record linkage for effective surveillance.

Amin Moradi, Mehdi Norouzi, Fatemeh Tavassoli, Tahereh Khosravi Asl, Ehsan MosaFarkhani2026-10-23
📄 medicine

Pushing the Boundaries of Partial Nephrectomy beyond T1a Renal Tumors: Does SPARE Nephrometry Score Offer Superior Predictive Value over RENAL and PADUA Nephrometry Scores in Larger Renal Tumors?

This prospective study of 193 patients undergoing partial nephrectomy, predominantly for tumors ≥cT1b, demonstrates that the SPARE nephrometry score offers superior predictive accuracy for long-term renal function decline compared to the RENAL and PADUA scores, particularly when integrated into a multivariable nomogram.

Nehal Hazem, Magdy Elsayed Mohamed Settein, Mohamed El Saied El Azab, Mostafa El-Ksas, Asmaa H. Mahmoud2026-10-23
📄 medicine

A longitudinally informed large language model for patient-level review of hormone test results in assisted reproductive technology: development, internal testing, and prospective silent evaluation

This study presents the development and evaluation of NovaMind, a longitudinally informed large language model that significantly improves the accuracy of patient-level hormone result reviews in assisted reproductive technology compared to conventional methods, while also exploring patient-based real-time quality control as a complementary system-level monitoring approach.

Xuesong Shang, Ran Gao, Xinxin Zhang, Fang Zhao, Juan Du, Yanmeng Qi, Meizhi Liu, Peng Li, Jing Liu, Ye Zhao, Shuyi Yang (…)2026-10-23
📄 medicine

Diagnostic Value of Peripheral Zone PSA Density for Detecting Clinically Significant Prostate Cancer in Men with Peripheral Zone MRI Lesions Running title: Peripheral Zone PSA Density in Prostate Cancer

This study demonstrates that peripheral zone-specific prostate-specific antigen density (PSAD_PZ) significantly outperforms conventional whole-gland PSAD and PSA in detecting clinically significant prostate cancer among men with peripheral zone-only MRI lesions, whereas zone-specific density offers no comparable advantage for transition zone targets.

Min Hyuk Kim, Hyo Myoung Lee, Jang Hee Han, Seung‑hwan Jeong, Ja Hyeon Ku, Cheol Kwak, Chang Wook Jeong, Hyeong Dong Yuk2026-10-23
📄 medicine

On-site slaughter and dressing in retail chicken outlets: Escherichia coli contamination and antimicrobial resistance on food-contact surfaces in Dhaka Division, Bangladesh

This study reveals that 50% of food-contact surfaces in retail chicken outlets across Dhaka Division, Bangladesh, are contaminated with multidrug-resistant *Escherichia coli*, predominantly showing high resistance to ampicillin, trimethoprim, and azithromycin, with the presence of *sul3* and *blaOXA-1* genes indicating significant antimicrobial selective pressure and widespread hygiene risks.

Md. Rihad, Nure Hamim Mohammod Ammar, Md. Niamul Shahadat, Shanta Islam, Uttam Kumar Roy, Md Rana Hossain, Abu Bakkar Si (…)2026-10-23
📄 medicine

Prerequisites for building academic research-practice partnerships in rehabilitation: municipal interest- holder perspectives from a qualitative mapping study

This qualitative mapping study of municipal stakeholders in Denmark identifies key prerequisites for successful academic research-practice partnerships in rehabilitation, emphasizing the need for equitable engagement, early involvement of municipal interest-holders, and continuous communication to bridge the gap between research agendas and practical clinical needs.

Signe Place Knudsen, Kim Gordon Ingwersen, Jemma Hawkins, Charlotte Overgaard2026-10-23