medicine papers | Gist.Science

Effectiveness of Psychoeducation Based Self Stigma Reduction Intervention Among Adolescents Living With HIV Attending Uch, Ibadan, Nigeria

A quasi-experimental study conducted at University College Hospital in Ibadan, Nigeria, found that a psychoeducation-based intervention, while highly satisfactory to participants, failed to produce statistically significant improvements in self-esteem, depressive symptoms, or HIV self-stigma among adolescents living with HIV compared to a peer support control group.

Rafiat Lawal, Haleem Abdurrahaman, Cornelius Ani, Tolulope Bella-Awusah, Olayinka Omigbodun2026-07-22

📄 medicine

Targeting LARP1 Suppresses Endometrial Cancer Growth and enhances Carboplatin Sensitivity

This study demonstrates that LARP1 acts as an oncogenic driver in endometrial cancer by promoting tumor growth and carboplatin resistance through E2F1 regulation, suggesting that targeting LARP1 could suppress tumor progression and enhance chemotherapy sensitivity.

Abdelrahman M. Elsayed, Marwa W. Eldegwy, Salama A. Salama2026-07-22

📄 medicine

A quantitative study: Investigating the diagnostic value of using dual-layer spectral CT in differentiating idiopathic inflammatory myopathy-associated interstitial lung disease

This quantitative study demonstrates that dual-layer spectral CT parameters, particularly in the lower lung lobes, can effectively differentiate idiopathic inflammatory myopathy-associated interstitial lung disease subtypes (ASS-ILD vs. PM/DM-ILD) even when they present with identical radiological patterns.

Songlin Xie, Shengzhong Wang, Ziyue Zhang, Yiwen Liang, Jianqun Yu, Rui QI, Chunyu Tan, Haiwei Liu, Xiaodi Zhang, Wenqi (…)2026-07-22

📄 medicine

Targeting EGFR1 and EGFR2 in Bladder Cancer: Receptor Profiling and Therapeutic Potential of 213Bi Alpha-Particle Therapy

This study demonstrates that targeted alpha-particle therapy using 213Bi-labeled trastuzumab and cetuximab effectively induces dose-dependent cytotoxicity and DNA damage in bladder cancer cells by exploiting abundant EGFR receptors, suggesting strong potential as a bladder-sparing treatment for patients resistant to standard BCG therapy.

Ece Erder, Satyendra Kumar Singh, Lu Lucy Xu, Chelsea Nayback, Jinda Fan, Terry Grimm, Daniel Isaac, Mike Zamiara, Kurt (…)2026-07-22

📄 medicine

A Randomized Controlled Animal Experimental Study: Citrate Carbon Dots Suppress Calcium Oxalate Stone Formation in Nephrolithiasis Mouse Model

This randomized controlled animal study demonstrates that citrate carbon dots effectively suppress calcium oxalate kidney stone formation and mitigate renal tubular damage in a glyoxylic acid-induced mouse model by reducing serum creatinine and urine oxalate levels while increasing urine citrate.

Yanting Lou, Feifei Wang, Zhengyao Song, Wei He, Jialuo Zhuang, Chaozhao Liang2026-07-22

📄 medicine

Competences, education and working environment of family physicians in Europe

This study analyzes data from 23 European countries to highlight significant variations in the organization, supervision, competences, and working conditions of family physicians, while identifying manpower shortages as a critical challenge across primary care systems.

Imre RURIK, Ádám BECZE, Péter TORZSA2026-07-22

📄 medicine

Long-Term Outcomes of Entecavir Therapy in Treatment-Naive Patients with Chronic Hepatitis B

This retrospective study of 230 treatment-naive chronic hepatitis B patients demonstrates that long-term entecavir therapy achieves high and durable viral suppression with an excellent safety profile, while identifying higher baseline HBV-DNA levels and lack of response at week 24 as key predictors of partial virological response.

Esma Eroğlu2026-07-22

📄 medicine

Synergistic benefits of mind mapping and digital surgical simulation for optimizing clinical thinking and operative competency in oral surgery residency case teaching

This study demonstrates that integrating mind mapping with digital software-guided surgical planning in oral surgery residency training significantly enhances residents' clinical thinking, operative competency, and overall teaching satisfaction compared to conventional lecture-based or mind mapping-only approaches.

Xiaofeng Xue, yun Liu, Ma yufeng2026-07-22

📄 medicine

Development and internal validation of a nomogram to predict operative management in patients with hepatic trauma: a retrospective cohort study

This retrospective cohort study developed and internally validated a nomogram using injury type, liver injury grade, hemoperitoneum, and early blood transfusion to accurately predict the need for operative management in patients with hepatic trauma, though external validation is required before clinical implementation.

pan Xiao, Lian-lu Jiang, Zi-jian Yu, Li Zhang2026-07-21

📄 medicine

Effectiveness of the culturally adapted version of Unplugged (“Yo Sé Lo Que Quiero”) among adolescents in Chile: results of a cluster randomized controlled trial.

This cluster randomized controlled trial in Chile found that the culturally adapted "Yo Sé Lo Que Quiero" program, while ineffective for reducing alcohol use among adolescents in economically vulnerable schools, significantly lowered tobacco and cannabis use, demonstrating the feasibility and selective efficacy of evidence-based prevention in Latin American settings.

Jorge Gaete, Ramírez Saray, Valentina Romo, Ricardo Araya2026-07-21

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