📄 Category

medicine

13805 papers

📄 medicine

A Retrospective Cohort Study of Independent Predictors for Long-Term Prognosis in Patients with Chronic Total Occlusion: Focus on SYNTAX Score and Platelet-Related Indices

This retrospective cohort study of 310 CTO patients undergoing PCI identifies higher SYNTAX scores, lower HDL-cholesterol, and specific platelet activity indices (high MPV and low platelet count) as independent predictors of one-year MACE, demonstrating that a combined model of clinical, anatomical, and platelet factors effectively stratifies risk, particularly in patients under 65.

Wei Zhang, Sihan Hu, Tao Guo2026-10-14
📄 medicine

Normative Measures of Colon Length and Width in Healthy Children Based on CT

This study establishes normative 3D CT-derived reference values for colon length and width in 162 healthy children aged 0–17 years, identifying body surface area as the primary predictor and defining thresholds (>141 cm for length, >3.4 cm for width) to aid in diagnosing anatomic abnormalities in children with therapy-resistant constipation.

Charlotte Anne Louise Jonker, Narendra Sundararama Shet, Yadav Bhupender, Melanie Annice Bowser, Briony Kate Varda, Joos (…)2026-10-14
📄 medicine

Neoplasm Reports in Patients with Multiple Sclerosis Treated with Disease-Modifying Therapies: An Analysis of the EudraVigilance Database

An analysis of the EudraVigilance database suggests that most multiple sclerosis disease-modifying therapies are not significantly associated with increased neoplasm reports, with the notable exception of mitoxantrone, which demonstrated a marked disproportionality in cancer-related adverse events.

R. Kułakowski, M. Chrzanowski, I . Rosciszewska-Żukowska, M. Niewada, D. Mirowska-Guzel2026-10-14
📄 medicine

Hyperventilation-Induced Heart Rate Response as a Marker of Cardiovascular Risk - Large-Scale Validation from the Courtois Cardiovascular Signature Program

This study validates that a blunted heart rate increase during hyperventilation serves as a simple, equipment-light marker for cardiovascular disease, demonstrating strong negative predictive value for ruling out risk in low-prevalence settings within a large cohort of 3,134 participants.

Matthias G. Friedrich, Margherita Leo, Abhinav Sharma, George Thanassoulis, Nadia Giannetti2026-10-14
📄 medicine

Outcomes of the Femoral Neck System for Intracapsular Femoral Neck Fractures: A Single-Centre, Single-Surgeon Experience of 69 Consecutive Cases

In a single-surgeon series of 69 consecutive intracapsular femoral neck fractures, the Femoral Neck System demonstrated reliable union and low mechanical failure rates even in displaced, high-shear-angle cases, suggesting that initial vascular injury rather than reduction quality alone is the primary determinant of adverse outcomes like non-union and avascular necrosis.

Nikita Bedi, Pratyaksha Jain, Gurinder Bedi, Mukesh Jain2026-10-14
📄 medicine

Monocyte Syk Phosphorylation as a Candidate Biomarker of Vasoplegic Shock After Cardiac Surgery with Cardiopulmonary Bypass: A Proof-of-Concept Observational Study

This proof-of-concept observational study suggests that the phosphorylation status of Syk in monocytes may serve as a candidate biomarker for predicting vasoplegic shock after cardiac surgery with cardiopulmonary bypass, although the findings require validation in larger independent cohorts due to a lack of statistical significance after correction for multiple comparisons.

K. Boussion, H. Flamant, M. Hurtado-Nedelec, S. Provenchère, J. Bex, J. Da Silva, A. Boutten, M. Parra, Luc de ChaiseMar (…)2026-10-14
📄 medicine

Community-Embedded Research Advisory Group as a Co-Creation Strategy to Support the Integration of Mental and Substance Use Disorder Screening and Management into Indian Primary Care: A Mixed-Methods Study

This mixed-methods study demonstrates that a community-embedded Research Advisory Group in Punjab, India, effectively facilitated the integration of mental and substance use disorder screening into primary care by leveraging stakeholder co-creation to identify contextual barriers and adapt implementation strategies, such as decentralizing medicine access and utilizing street theatre for awareness.

Sakshi Setia, Abhishek Ghosh, Blessy B George, Manya Shukla, Nagma Imam, Manju Mehra, Renjith R Pillai, Kshitiz Sharma (…)2026-10-14
📄 medicine

Knowledge, attitudes and clinical awareness of myogenous temporomandibular disorders among senior dental students: a cross-sectional study

This cross-sectional study of senior dental students reveals a significant gap between their theoretical endorsement of multidisciplinary management for myogenous temporomandibular disorders and their limited clinical readiness, highlighting an urgent need for structured, case-based training and interprofessional education to bridge the divide between knowledge and practice.

Erkin Ergezen, Gaye Keser, Filiz Namdar Pekiner, Yasemin Kulak Özkan2026-10-14
📄 medicine

Prospective Validation of the Canadian Syncope Risk Score in an Indian Emergency Department: Performance in Syncope and Near-Syncope

This prospective study validates the Canadian Syncope Risk Score in an Indian emergency department, demonstrating its strong diagnostic accuracy for predicting 30-day serious adverse events in both syncope and near-syncope patients, thereby supporting its use to standardize disposition decisions and reduce unnecessary admissions in non-Western settings.

Manan Shah, Sanjay Mehta, Sagar Shah, Deepack Kotharthil2026-10-14
📄 medicine

NPC-EVs ameliorate ischemic brain injury by enhancing microglial phagocytosis and anti- inflammatory responses via TREM2-mediated lipid metabolic reprogramming

This study demonstrates that neural progenitor cell-derived extracellular vesicles (NPC-EVs) ameliorate ischemic brain injury by enhancing microglial phagocytosis and anti-inflammatory responses through TREM2-mediated lipid metabolic reprogramming, thereby improving neurological recovery in stroke models.

Lin Zhang, Wei Wei, Wenqiang Xin, Guoqiang Hou, Xinhang Xu, Xiaolan Yang, Yaohua Pan, Feng Jia, Xiaohua Zhang2026-10-14