13805 papers
This study demonstrates that while Imagery Rehearsal Therapy significantly improves PTSD symptoms and reduces cortical hyperarousal in patients with traumatic nightmares, adding Targeted Memory Reactivation does not provide further clinical benefits despite inducing additional neural changes during REM sleep.
This systematic review of 85 stroke studies reveals that while reporting on Patient and Public Involvement (PPI) processes is robust, there is a critical gap in documenting the demographic and clinical characteristics of PPI partners, underscoring the urgent need for a companion reporting tool to ensure equity and representativeness in stroke research.
This paper presents the co-produced development and pilot evaluation of the Oxford Cognitive Screening Platform (OCX), a modular and adaptive digital tool designed to align with clinical guidelines for personalized post-stroke cognitive screening across six domains, demonstrating high acceptability and initial validity in stroke survivors and healthy controls.
This scoping review of 20 studies across 14 low- and middle-income countries reveals that traumatic brain injury imposes substantial direct and indirect financial burdens on households and health systems, characterized by catastrophic expenditure and affordability barriers, while highlighting significant evidence gaps regarding long-term rehabilitation and societal costs.
This systematic review and meta-analysis demonstrates that dosimetry-guided, personalized 177Lu-DOTATATE PRRT for advanced GEP-NETs is safe and feasible, offering improved long-term survival and disease control without increasing severe nephrotoxicity or hematological toxicity compared to fixed-dose regimens.
This longitudinal qualitative case study from rural Kerala, India, reveals that the integration of a Physician Associate into primary care occurs through a progressive process of negotiated embedding and observed capability rather than simple task delegation, characterized by bounded physician-linked entrustment and expanded coordination roles that improve workflow despite lagging formal institutionalization.
This pilot feasibility study demonstrates that self-supervised representation learning can effectively extract clinically relevant respiratory information from unlabeled ventilator waveforms, achieving strong performance in ventilator mode classification, physiological variable prediction, and waveform reconstruction.
This U.S. ecological analysis reveals that higher county-level radiologist density is significantly associated with lower cancer mortality, identifying over 1,300 counties without radiologists as high-burden areas where AI-augmented diagnostic capacity could potentially prevent hundreds of annual deaths.
This systematic review of 14 studies involving over 150,000 patients reveals that drug-drug interactions involving clozapine are common across care settings, highlighting the urgent need for improved medication review processes and integrated prescribing systems to mitigate preventable harm.
This study demonstrates that peptidyl arginine deiminase (PAD)-mediated citrullination of serine proteases in rheumatoid arthritis enhances their enzymatic activity and stability, confers autoantigenicity, and drives joint tissue damage, suggesting PAD inhibition as a potential therapeutic strategy.