📄 medicine

Equal heat, unequal harm: rural–urban disparity in heat-related illness and a burden-matched comparison of heat-alert design levers in Korea

This study of Korean municipalities reveals that rural areas suffer disproportionately higher heat-related illness despite similar temperatures, demonstrating that increasing alert frequency is far more effective at capturing cases than adjusting heat indicators or localization, though region-specific thresholds remain crucial for equity.

Eunjung CHO2026-10-14
📄 medicine

Joint Trajectories of Peak Expiratory Flow and Handgrip Strength and Subsequent Disability, Frailty, and Mortality Among Middle-Aged and Older Chinese Adults: A CHARLS Cohort Study

This CHARLS cohort study demonstrates that among middle-aged and older Chinese adults, a joint trajectory of persistently low peak expiratory flow and declining handgrip strength is strongly associated with increased risks of subsequent disability, frailty, and all-cause mortality compared to those with high and stable functional levels.

Yiwen Hu, Yao Zhang, Yuan Ren, Hao Qin, Huichao Liu, Hui Zhao2026-10-14
📄 medicine

Ozanimod in Patients with Ulcerative Colitis - Prospective Real-World Evidence from the Dutch ICC Registry.

This prospective real-world study from the Dutch ICC Registry indicates that ozanimod demonstrates moderate effectiveness in inducing clinical remission and maintains a favorable safety profile for patients with ulcerative colitis, although a significant proportion discontinued treatment within the first year.

Loriane M.M. Verleye, Donna Erven, Zlatan Mujagić, Myrthe R. Naber, Dianne G. Bouwknegt, Tessa E.H. Römkens, Luuk F. Wym (…)2026-10-14
📄 medicine

Sedentary behaviour increases the risk of infection and death: a two-sample Mendelian randomisation study

This two-sample Mendelian randomisation study provides evidence that genetically proxied higher sedentary behaviour increases the risk of various infections and infection-related mortality, while higher moderate-to-vigorous physical activity is associated with reduced infection risk, though causal interpretations are tempered by potential pleiotropy and heterogeneity.

Mikael Eriksson, Bram Burger, Miklos Lipcsey, Michael Marks-Hultström, Karl Stattin2026-10-14
📄 medicine

Determinants of ePROM Implementation and Scale-Up in Routine Care across a Universal Healthcare System: A Retrospective Population-Based Observational Study

This retrospective population-based study demonstrates that large-scale ePROM implementation is feasible within a universal healthcare system, revealing that organizational context, workflow integration, and intervention design are stronger determinants of professional adoption and patient completion than individual demographic characteristics.

Maria-Mercedes Nogueras, Marina Ramiro-Pareta, Xavier Alzaga, David López, Júlia Folguera, Gerard Carot-Sans, Alba Jimén (…)2026-10-14
📄 medicine

Emergency department crowding and cardiac arrest: A retrospective time-series study

This retrospective time-series study found that higher daily emergency department occupancy rates are significantly associated with increased cardiac arrest rates, although the implementation of a fast-track model to reduce crowding did not result in a statistically significant immediate change in cardiac arrest incidence.

Halfdan Lauridsen, Thomas A Schmidt, Jesper Juul Larsen, Anna Tuxen, Jacob Peter Hartmann2026-10-14
📄 medicine

Implementation of a Rapid Dietary Assessment Tool in Breast Cancer Care

This study demonstrates that Diet ID™, a brief and image-based dietary assessment tool, is a feasible and low-burden screening method for integrating dietary evaluation into breast cancer care across all treatment stages, as evidenced by high patient participation rates and rapid completion times.

Carissa G. Mindemann, Lia D’Addario, Janise M. Roh, Raymond Liu, Samantha Siegel, Marilyn L. Kwan, Lawrence H. Kushi, Ro (…)2026-10-14
📄 medicine

10-Year Survivorship, Metastatic Risk, and Clinicopathologic Characteristics of Early- Onset Pancreatic Cancer: A Meta-Analysis and Meta-Regression

This meta-analysis of over 364,000 patients reveals that early-onset pancreatic cancer, while representing only 6.1% of cases and presenting with higher metastatic risk and advanced stages, is associated with a 25% lower hazard of death compared to non-early-onset disease and is strongly linked to smoking, highlighting the need for targeted early detection in younger smokers.

Erlangga Masykur Kynaya, Christopher Daniel Tristan, Nadia Ramadhina Salfistra, Jauza ’ ‘Athifah Hanun, Coana Sukmagauta (…)2026-10-14
📄 medicine

A safety gate for automated DAT-SPECT interpretation: detection of atypical patterns

This study developed and validated a simple safety gate using hemispheric caudate binding ratio asymmetry to effectively identify atypical DAT-SPECT patterns that could confound automated deep learning interpretation, thereby enhancing the robustness of clinical diagnostic workflows.

Ivayla Apostolova, Thomas Buddenkotte, Monika Primke, Laurin Bruer, Ariana Marandi, Susanne Klutmann, Rickmer Braren, Ph (…)2026-10-14