4098 papers
This prospective cohort subanalysis demonstrates that heterozygous GBA1 variants do not predict worse global cognitive outcomes one year after subthalamic nucleus deep brain stimulation in Parkinson's disease patients, despite some specific domain deficits compared to non-carriers.
This study of 178 dental practitioners in Enugu State reveals that while most hold positive attitudes toward ergonomics, adherence to standards is low due to insufficient knowledge, training, and equipment, highlighting the need for improved education and resource provision to enhance safety and job satisfaction.
This population-based SEER analysis of over 11,000 chemotherapy-treated triple-negative breast cancer patients reveals that an advanced systemic disease burden (Stage IV proxy) is an independent predictor of significantly increased risks for early adverse clinical outcomes, underscoring the need for risk-adapted surveillance strategies.
This prospective observational study establishes normative reference values and demonstrates high reproducibility for pulmonary venous flow velocities in well newborns born at ≥35 weeks gestation during the first two days of life, characterizing the physiological transition from fetal to postnatal circulation.
This study of pediatric Familial Mediterranean Fever patients indicates that while the E148Q variant modifies the clinical phenotype by increasing chest pain frequency and disease severity in those with M694V mutations, it does not significantly alter systemic inflammatory activity.
This systematic review and meta-analysis of 12 studies demonstrates that aneurysm wall enhancement on vessel wall MRI, particularly circumferential enhancement, is strongly associated with intracranial aneurysm instability, including both growth and rupture, supporting its potential role as a valuable adjunct for risk stratification.
This prospective multicenter study reveals that while the incidence of stoma outlet obstruction (SOO) increases with the timing of high-output stoma onset, late-onset high-output stoma (occurring on or after postoperative day 6) serves as a highly specific clinical indicator of underlying SOO rather than a sensitive screening marker, correlating with significantly longer hospital stays.
This paper reports two cases of Parkinsonism-hyperpyrexia syndrome triggered by globus pallidus internus deep brain stimulation withdrawal, highlighting that while hyperthermia resolves rapidly upon device reactivation, creatine kinase levels remain elevated for days, necessitating continued biochemical monitoring to prevent premature de-escalation of care.
This study demonstrates that newly synthesized coumarin-piperazine derivatives, particularly compound 4s, effectively alleviate inflammatory bowel disease by inhibiting the NF-κB pathway to reduce IL-6 expression, thereby mitigating intestinal inflammation with low toxicity.
This study utilized real-world databases (FAERS and JADER) to detect significant escitalopram-related suicide risk signals, identified serotonergic and dopaminergic pathways as underlying molecular mechanisms, and demonstrated that machine learning models for predicting adverse events require region-specific retraining to maintain accuracy across different populations.