Covariate Adjustment and Interpretation of Mortality Estimates in ADHD: A Systematic Review and Meta-analysis
This systematic review and meta-analysis of 15 studies reveals that while ADHD is associated with elevated mortality, the evidence is of very low certainty due to high heterogeneity, substantial variation in covariate adjustment strategies, and wide prediction intervals that often cross the null, cautioning against interpreting pooled estimates as precise measures of risk across different settings.