📄 medicine

Selective versus complete caries removal in deep posterior lesions: a six-month prospective pilot

This six-month prospective pilot study comparing selective and complete caries removal in deep posterior lesions found that selective removal showed a clinically relevant, numerically higher success rate and pulp sensibility than complete removal, although the difference did not reach statistical significance in a two-sided analysis, highlighting the need for larger, longer-term trials.

Ana Iglesias Poveda2026-07-10
📄 medicine

Neuromuscular electrical stimulation versus combined aerobic and resistance exercise versus health literacy intervention for glycemic control in institutionalized older adults with type 2 diabetes: study protocol for a randomized controlled trial

This study protocol outlines a three-arm randomized controlled trial comparing the efficacy of neuromuscular electrical stimulation, supervised combined aerobic and resistance exercise, and health literacy education on glycemic control and secondary outcomes in institutionalized older adults with type 2 diabetes over a 12-week period.

Carlos Tavares, Rui Soles Gonçalves, Rocío Llamas-Ramos2026-07-10
📄 medicine

Tirzepatide Attenuates Diabetes-Associated Testicular Inflammation and Sperm DNA Fragmentation in Obese Diabetic Mice: Potential Pleiotropic Effects Beyond Glycemic Control

This study demonstrates that tirzepatide ameliorates diabetes-induced testicular inflammation, oxidative stress, and sperm DNA fragmentation in obese diabetic mice through a GIPR-mediated mechanism in testicular macrophages, offering protective effects beyond its glycemic control capabilities.

Yusaku Mori, Naoya Osaka, Michishige Terasaki, Hironori Yashima, Tomomi Saito, Daiki Tokado, Madoka Ogino, Makoto Ohara (…)2026-07-10
📄 medicine

Household Poverty and Physical Activity Endpoint Divergence Among U.S. Children and Adolescents

Using 2023–2024 National Survey of Children's Health data, this study reveals that household poverty in the U.S. is associated with a polarization of physical activity among children and adolescents, where those in the lowest income groups are simultaneously more likely to be completely inactive and more likely to meet daily activity guidelines compared to their peers.

Ruchen She, Jing Guo2026-07-10
📄 medicine

Physical Activity and Sedentary Behavior are Independently Associated with Combined Skeletal Muscle Index and Bone Mineral Density Status among Community-Dwelling Middle- Aged Women

This cross-sectional study of 199 community-dwelling Japanese women aged 40–64 found that higher physical activity and lower sedentary time are independently associated with a more favorable combined status of skeletal muscle mass and bone mineral density.

Atsunori Itagaki, Issei Sugimoto, Ikue Kondo, Takumi Saito, Yugo Kimura, Sumika Ogawa, Koharu Takahashi, Aoba Kishi, Tom (…)2026-07-10
📄 medicine

Do wording and response option modifications to the EQ-HWB-9 affect measurement performance? Evidence from the Netherlands and the USA

This study demonstrates that the modified EQ-HWB-9 v1.2, which features refined wording and response options, exhibits at least equivalent or slightly superior psychometric performance compared to the v1.1 version across both the Netherlands and the USA, thereby validating the adopted modifications.

Akanksha Akanksha, Andrea De Palma, Fanni Rencz, Tessa Peasgood, Brendan Mulhern, Aureliano Paolo Finch2026-07-10
📄 medicine

Scoliosis in children and adolescents with NF1 and plexiform neurofibromas: a preliminary study of clinical phenotypes and eosinophil and basophil features

This preliminary study of children and adolescents with NF1 and plexiform neurofibromas identifies paravertebral tumor infiltration and peripheral eosinophil levels as independent factors associated with scoliosis, suggesting that combining clinical phenotypes with specific granulocyte characteristics may improve risk stratification for this musculoskeletal complication.

Zhixuan Fang, Qiaoyin Liu, Yifan Liu, Yanzhen Li, Nian Sun, Junlong Tan, Zhiyong Liu, Shengcai Wang2026-07-10
📄 medicine

The Efficacy and Safety of Radiofrequency Ablation for Trachea-Adjacent cT1N0M0 Papillary Thyroid Carcinoma: a five-year follow-up study

This five-year follow-up study demonstrates that ultrasound-guided radiofrequency ablation is an effective and safe treatment option for cT1N0M0 papillary thyroid carcinoma adjacent to the trachea, showing comparable disease-free survival and recurrence rates to distant lesions despite a slightly higher complication risk associated with dorsal tumor location and tracheal contact.

Zimeng Lv, Jingchun Yang, Yifan Wang, Ying Chang, Xufen Yang, Xiaoxia Jia, Zhenpeng Leng2026-07-10
📄 medicine

Effects of Maternal and Socio-economic Characteristics on Infantile Hypertrophic Pyloric Stenosis

This study of 90 mother-infant dyads identifies maternal age ≥26 years, employment status, diabetes, hypertension, and primary education as significant predictors of infantile hypertrophic pyloric stenosis, while also noting a high prevalence (11.1%) and demographic trends toward male, first-born, and rural infants from lower socioeconomic backgrounds.

A. K. M. Ahsanul Khabir, Md. Ariful Haque, Masud Rana2026-07-10
📄 medicine

Effectiveness of a Virtual Reality-Based Intervention to Reduce Anxiety and Pain in Pediatric Nuclear Medicine: A Randomized Clinical Trial

This randomized clinical trial demonstrates that a virtual reality-based intervention significantly reduces anxiety in pediatric patients undergoing nuclear medicine procedures, offering a safe, non-pharmacological alternative to sedation, although it did not significantly impact perceived pain or caregiver satisfaction.

Marta FERRAZ-TORRES, Arantxa BUJANDA-SAINZ DE MURIETA, Cristina GARCÍA-VIVAR, Paula ESCALADA-HERNÁNDEZ, Nuria LASSA-TODA (…)2026-07-10