13909 papers
This case report describes a patient with first-line immunotherapy-resistant GFAP astrocytopathy whose pretreatment cerebrospinal fluid exhibited a Th1/Tc1-polarized cytokine profile, suggesting that CD8⁺ cytotoxic T cell-mediated injury may underlie treatment refractoriness and warrant early escalation to second-line immunotherapy.
This study indicates that while new-onset hypertensive patients generally exhibit impaired coronary microvascular function compared to controls, those with salt-sensitive hypertension—particularly when defined by systolic blood pressure changes—demonstrate more pronounced dysfunction than their salt-resistant counterparts.
This four-year retrospective study in a tertiary care setting in Chattogram, Bangladesh, reveals that prior antibiotic exposure, particularly to carbapenems and cephalosporins, is strongly associated with the emergence of multidrug-resistant CRE infections, while identifying colistin and tigecycline as the most effective remaining therapeutic options against a pathogen that carries a high mortality rate.
This case report describes a fatal, fulminant anti-AMPAR encephalitis in an 84-year-old woman characterized by markedly elevated cerebrospinal fluid IL-6 levels and prominent CD8-positive T-cell infiltration, highlighting the potential severity of this condition even in the absence of an underlying malignancy.
This population pharmacokinetic study and simulation demonstrate that while levetiracetam dosing is influenced by body weight and concomitant medications, a three-times-daily regimen provides more stable plasma concentrations compared to twice-daily dosing, potentially leading to longer seizure-free periods in epilepsy patients.
This case report describes the successful laparoscopic management of a rare horseshoe appendix (Type D anomaly) with dual perforated cecal insertions in a 60-year-old diabetic woman, emphasizing the critical need for systematic intraoperative exploration to ensure complete resection and prevent complications in such anatomically complex presentations.
This retrospective cohort study demonstrates that preserving the infrapatellar fat pad using PDS suture retraction during anterior cruciate ligament reconstruction significantly reduces postoperative fibrosis and improves early pain and functional outcomes compared to conventional selective resection, although these findings require prospective validation.
This 2026 randomized controlled trial conducted in Tigray demonstrates that a screening and brief intervention strategy significantly reduced risky post-war alcohol consumption among public hospital outpatients at 6- and 12-month follow-ups compared to a control group.
This study demonstrates that balancing training data by sex is insufficient to ensure fairness in AI-based emergency triage models, as a female-only model generalized well to both sexes while a male-only model performed poorly for women, highlighting the need to address structural biases during the design phase rather than relying solely on data composition.
This case report describes the rare discovery and successful surgical removal of a large, asymptomatic glass fragment retained in the pleural space for a decade in a skydiver, highlighting the challenges of detecting and managing such foreign bodies that may migrate years after the initial trauma.