📄 medicine

Trust, place, and polysubstance use shape the feasibility of community-based drug checking in the Southern United States: A mixed-methods implementation study

This mixed-methods study in Fulton County, Georgia, reveals that while community-based drug checking is urgently needed to address the volatile drug supply, its implementation is significantly hindered by institutional mistrust, reliance on known drug sources, and the complexities of polysubstance use, indicating that legal reforms and testing tools alone are insufficient without addressing these social and contextual barriers.

Sarah Febres-Cordero, Roesheen McGilvery, Daniel J. Smith, Lydia Vlachou, Abigail (Gale) Pires, Fawaz Shanun, Nadiah Cun (…)2026-10-11
📄 medicine

The relationship between cross-reactive Plasmodium vivax antibody responses and P. knowlesi parasitaemia and clearance

This study demonstrates that pre-existing cross-reactive *Plasmodium vivax* antibodies are associated with reduced baseline *P. knowlesi* parasitaemia and slightly slower parasite clearance in Malaysian patients, suggesting a partial but complex role in influencing infection outcomes.

Jeyamalar T. Thurai Rathnam, Megha Rajasekhar, Rhea J. Longley, Anju Abraham, Timothy William, Sitti Saimah Sakam, Danie (…)2026-10-11
📄 medicine

PCR-based co-detection of respiratory bacterial pathogens among hospitalized COVID-19 patients: Early-pandemic data from Golestan Province, Iran

A retrospective study of hospitalized COVID-19 patients in Golestan Province, Iran, found that bacterial DNA from various respiratory pathogens was frequently detected via PCR in upper-airway specimens, with *Pseudomonas aeruginosa* specifically associated with severe disease, though the findings likely reflect bacterial colonization rather than active co-infection due to methodological limitations.

Ali Vaez, Hamid Jalali, Ahdieh Izanloo, Morvarid Hamrahjoo, Hadi Razavi Nikoo, Alijan Tabarraei, Abdolvahab Moradi, Sade (…)2026-10-11
📄 medicine

Endoscopic intralesional platelet-rich plasma (PRP) injection after balloon dilation for colonic Crohn's disease strictures: a pilot study

This prospective pilot study demonstrates that endoscopic intralesional platelet-rich plasma injection following balloon dilation for colonic Crohn's disease strictures is a technically feasible and safe procedure, although it did not significantly reduce restenosis rates at 3 weeks or 1 year.

Yi Lu, Tao Yang, Jing Li, Jun Deng, Wei Wang, Qianqian Ji, Huisi Mai, Zhiyin Gao, Mei Xie, Xiuqun Yuan, Lishuo Shi, Jiac (…)2026-10-11
📄 medicine

Collapsing Focal Segmental Glomerulosclerosis Progression to ESRD Following Combination Therapy with Pembrolizumab and Enfortumab Vedotin: A Case Report

This case report describes a 76-year-old male with pre-existing chronic kidney disease who experienced rapid, irreversible progression to end-stage renal disease due to collapsing focal segmental glomerulosclerosis following combination therapy with pembrolizumab and enfortumab vedotin, suggesting a novel synergistic mechanism of podocyte injury that warrants careful nephrology evaluation before treatment.

George Hitti, Caroline Gee, Johnathan Zuckerman, Ramy Hanna2026-10-11
📄 medicine

Genome-based benchmarking of 177 different breast cancer polygenic risk scores

This study benchmarks 177 breast cancer polygenic risk scores in a hereditary breast and ovarian cancer cohort, demonstrating that top-performing scores converge on similar accuracy and variant composition, thereby offering a cost-effective tool to stratify risk for patients lacking monogenic findings and close a critical diagnostic gap.

Ertugrul Eyol, Ulrike Faust, Marc Sturm, Antje Stäbler, Silja Gauß, Kristin Bosse, Ines Gruber, Andreas Hartkopf, German (…)2026-10-11
📄 medicine

Manual Sleep Stage and Arousal Scoring Agreement between a Reduced Montage and Conventional Polysomnography in Adults with Obstructive Sleep Apnea

This retrospective study demonstrates that a self-applied reduced frontal EEG montage achieves substantial agreement with conventional polysomnography for manual sleep stage and arousal scoring in adults with obstructive sleep apnea, offering a viable alternative for reliable sleep assessment when full PSG is impractical.

Megan McPhee, Kristófer Montazeri, Þóra Björg Sigmarsdóttir, Sigurður Ægir Jónsson, Eydís Arnardóttir, Eysteinn Finnsson (…)2026-10-11
📄 medicine

Incidence, outcomes, and mortality of fungal infections in pediatric patients undergoing anticancer therapy or transplantation: a nationwide cohort study

This nationwide cohort study of Polish pediatric patients reveals that while the incidence of invasive fungal disease is comparable between those undergoing anticancer therapy and hematopoietic cell transplantation, the latter group faces a nearly fourfold higher infection-related mortality rate, underscoring the urgent need for improved supportive care and prophylaxis.

Monika Richert-Przygonska, Anna Fraczkiewicz-Jablonska, Krzysztof Czyzewski, Patrycja Zalas-Wiecek, Olga Gryniewicz-Kwia (…)2026-10-11
📄 medicine

Facilitative Effects of Add-on Therapy with Tadalafil in Stone Passage After Shockwave Lithotripsy; A Randomized Clinical Trial

This randomized clinical trial found that while adding tadalafil to tamsulosin did not significantly improve stone passage rates or time after shockwave lithotripsy, it did significantly reduce pain scores and the duration of hematuria with negligible additional side effects.

Ali Kamalati, Mohammadamin Hesamarefi, Amir Hossein Hassani, Mohammadhadi Hesam-Arefi, Hamid Pakmanesh2026-10-11