📄 Category

medicine

4248 papers

📄 medicine

Early modulation of pituitary gonadotropins during PD-1 inhibitor–based immunochemotherapy in patients with solid tumors

This longitudinal study reveals that PD-1 inhibitor-based immunochemotherapy in patients with lung and colorectal cancer induces selective, progressive alterations in pituitary hormones (specifically increasing FSH and prolactin while decreasing the LH/FSH ratio) without causing significant changes in circulating gonadal sex steroids, suggesting a primary pituitary-level endocrine response rather than overt gonadal dysfunction.

Deyu Yang, Xinrong Chen, Zhichao Li, Mei Ouyang, Ke Wang, Chuangjie Zheng, Linzhu Zhai2026-07-10
📄 medicine

Motivations, perceptions, and barriers to gastric cancer screening among communicatively vulnerable adults in Belgium and the Netherlands: Insights from the TOGAS project

This qualitative study within the TOGAS project reveals that communicatively vulnerable adults in Belgium and the Netherlands prefer non-invasive gastric cancer screening methods like breath tests and rely heavily on healthcare providers' recommendations, while facing significant barriers related to language, low health literacy, and the need for tailored educational support.

Tessa Groen, Noa E. A. Kapteijn, Wessel van Veerdonk, Janet Takens, Radu A. Farcas, Dan L. Dumitrascu, Judith Honing, V. (…)2026-07-10
📄 medicine

Measles vaccination coverage and associated factors among children aged 6 to 60 months presenting with measles in major public hospitals in war torn regions of Sana a city Yemen a cross sectional study

This cross-sectional study of 350 children with measles in Sana'a, Yemen, reveals alarmingly low vaccination coverage (with 75.43% unvaccinated) driven primarily by caregiver fears, paternal refusal due to rumors, geographical barriers, and maternal illiteracy, underscoring the urgent need for targeted health education and localized immunization campaigns to address these critical determinants.

Ahmed H. Al-Shahethi, Noura Ali Noraddin, Fares A. Mahdi, Emad A. Al-Shameri, Gamil Ghaleb Alrubaiee, Abdulgader Mohamme (…)2026-07-10
📄 medicine

Diagnosis of Lymph Node Metastasis in Muscle - Invasive Bladder Urothelial Carcinoma by CT Combined with the Expressions of VEGF-C, CK20 and PYCR1

This study demonstrates that combining preoperative enhanced CT with the immunohistochemical expression of VEGF-C, CK20, and PYCR1 significantly improves the diagnostic accuracy for predicting lymph node metastasis in patients with muscle-invasive bladder urothelial carcinoma compared to CT alone.

Yujie Zhou, Jian Liu, Qinghua Jiang, Quan Yang, Zhuo Li2026-07-10
📄 medicine

Understanding Black Women's Lived Experiences of Medical Mistrust and Trust in the Reproductive Care Setting: A Nested Sequential Explanatory Mixed Methods Study

This nested sequential explanatory mixed-methods study of Black women in Alachua County, Florida, identifies specific demographic factors associated with medical mistrust in reproductive care and highlights five key provider characteristics—transparency, humanizing interactions, comfort, acknowledgment of patient insight, and time—that are essential for building trust, ultimately calling for structural and interpersonal interventions to support Black women and reduce their need for self-advocacy.

Karen Awura-Adjoa Ronke Coker, Tyler S. Nesbit, Brittney N. Dixon-Daniel, Arie Hendrik Havelaar, Nancy Hunt, Sarah Milbr (…)2026-07-10
📄 medicine

PD-L1 suppression sensitizes CaSki cells to Paclitaxel in cervical cancer

This study demonstrates that suppressing PD-L1 expression via siRNA sensitizes CaSki cervical cancer cells to Paclitaxel by enhancing apoptosis, inhibiting migration and colony formation, and reducing the effective drug dose, suggesting a promising combined therapeutic strategy for cervical cancer.

Parya divsalar, Elham Poursaei, AmirAli Mokhtarzadeh, Amir Baghbanzadeh, Sahar Safaei, Elaheh zafari, Behzad Baradaran2026-07-10
📄 medicine

Esophago-Pericardial Fistula Associated with a Sharp Foreign Body Presenting with Tension Pneumopericardium and Cardiac Arrest During Endoscopy: A Case Report

This case report describes a rare instance of cardiac arrest caused by tension pneumopericardium resulting from an esophago-pericardial fistula due to a sharp foreign body, which was successfully managed through emergent pericardiocentesis, endoscopic foreign body removal, and surgical intervention.

Mohammad Jafari, Rayeheh Shekl abadi, Parvin Bahrami, Azam teimouri, Alireza Nematollahi2026-07-10
📄 medicine

A service evaluation of restraint, seclusion and escalation in inpatient mental health care: a retrospective observational study in England

This retrospective observational study of over 41,000 incidents in English inpatient mental health services reveals that restrictive practices operate as a two-stage system where service configuration determines restraint frequency and ward-level context influences escalation to seclusion, suggesting that reduction strategies must target both incident rates and the processes governing escalation.

Ndukwe Walter Ugwuocha, Oladayo Bifarin, Chengeto Shoko, Simon Nielson, Alexander Challinor, Deborah Morgan, Andrew Jone (…)2026-07-10
📄 medicine

A nomogram to predict shoulder dystocia in patients during labor: a retrospective cohort study

This retrospective cohort study developed and validated a nomogram based on six independent predictors—estimated fetal weight >4000 g, abdominal circumference–head circumference difference ≥2.5 cm, gestational diabetes, maternal BMI >28 kg/m², short stature ≤150 cm, and prolonged second stage of labor—to effectively stratify the risk of shoulder dystocia during vaginal delivery.

Peiran Yang, Zhiyi Yang, Xiaojun Guo, Jun Yan, Yongfei Yue2026-07-10