📄 Category

medicine

13909 papers

📄 medicine

Dosimetric Impact of Collimator Angle and Arc Number on Target Dosimetry and Organ-at-Risk Sparing in Volumetric Modulated Arc Therapy for Thyroid-Associated Ophthalmopathy

This study demonstrates that in volumetric modulated arc therapy for thyroid-associated ophthalmopathy, a four-arc configuration with a 60°–300° collimator angle offers the optimal balance between target dosimetry and organ-at-risk sparing, while a 75°–285° angle provides the best organ protection, and 0° or 15° angles should generally be avoided.

KANG ZHANG, JINGCONG CHEN, YUHAN CHEN, LU ZOU, ZHE WANG, FENGWEI RAN2026-10-11
📄 medicine

Navigating Equity, Diversity and Inclusion in Simulation-Based Education Debriefs: A Qualitative Study of Educators’ Lived Experience

This qualitative study of 11 UK simulation educators reveals that while they frequently encounter unplanned equity, diversity, and inclusion (EDI) themes during debriefs, they often retreat from these discussions due to fears of causing harm, identity-related tensions, and a lack of specific faculty development support, highlighting an urgent need for targeted training to bridge the gap between EDI theory and practice.

Simisola Sodeinde, Hannah Maple2026-10-11
📄 medicine

Social network and ikigai are interconnected pathways to frailty, with physical activity as an independent parallel input, among community- dwelling older Japanese adults in the Kyotango longevity area

This study of community-dwelling older adults in Kyotango, Japan, demonstrates that while physical activity independently reduces frailty, social networks primarily mitigate frailty by enhancing ikigai, which serves as a critical, intervenable mediator in a parallel-pillar architecture of healthy longevity potentially linked to beneficial IL-6 signaling.

Yuji Naito, Takeshi Yasuda, Hiroaki Kitae, Katsura Mizushima, Norihiro Ouchi, Atsuo Adachi, Tadaaki Kamitani, Jin Narumo (…)2026-10-11
📄 medicine

The influence of cognitive decline on the severity and quantity of drug-drug interactions

This study of older Polish primary care patients reveals that while cognitive decline does not independently predict the risk or severity of drug-drug interactions, the daily medication count serves as the primary determinant, suggesting that structured medication reviews should be triggered by polypharmacy regardless of cognitive status.

Wojciech Timler, Minh Tuan Hoang, Joanna Kempa-Timler, Dorota Religa, Przemysław Kardas2026-10-11
📄 medicine

Mechanical Digitorum Sensory Stimulation Enhances Hemiplegic Upper Limb Motor Function in Stroke Patients by Increasing Cortical Excitability and Functional Connectivity

This study demonstrates that Mechanical Digitorum Sensory Stimulation (MDSS) effectively improves upper-limb motor function and reduces spasticity in stroke patients by enhancing cortical excitability and functional connectivity, as evidenced by clinical assessments and fNIRS imaging.

Wei Huang, Heyan Zhang, Jinqiang Yu, Yuan Ma, Qiqi Li, Rui Wu, Yuyou Yao, Shuting Zhang, Yongfeng Hong2026-10-11
📄 medicine

Social isolation, loneliness and functional transitions among middle-aged and older adults with cardiometabolic multimorbidity: a multistate Markov analysis of CHARLS

This multistate Markov analysis of Chinese adults with cardiometabolic multimorbidity reveals that while loneliness primarily accelerates the onset of functional decline, the combination of loneliness and social isolation significantly impairs recovery from disability and increases post-disability mortality, resulting in a substantial reduction in expected years of independent living.

Jiayi Sun, Zuochen Xue, Aijuan Cheng2026-10-11
📄 medicine

Patient-derived organoids inform treatment response and clinical outcomes in tumors of uncertain differentiation

This study demonstrates that patient-derived organoid (PDO) drug sensitivity profiling effectively guides personalized treatment for tumors of uncertain differentiation, resulting in significantly improved progression-free survival and clinical outcomes compared to standard care.

Qian Kong, Lina Tang, Chenming Zhong, Yujing Huang, Chenghao Yin, Yunyu Wang, Hao Luo, Qingcheng Yang, Dongdong Cheng, Y (…)2026-10-11
📄 medicine

Application Effects of Modified Coronectomy in Mandibular Third Molars with High-Risk Proximity to the Mandibular Canal and Characteristics of Residual Root Migration

This study demonstrates that modified coronectomy effectively prevents inferior alveolar nerve injury in high-risk mandibular third molar cases with minimal postoperative pain, despite requiring longer operative time, while revealing that residual root migration over 12 months is influenced by root length and morphology, with 5–10 mm roots showing the greatest stability.

Jianxian Hu, Jianguo Xu, Mengjie Shen, Xiaoyi Liu, Ruixue Cheng, Yuanyuan Ma, Gang Li, Yu Xiong2026-10-11
📄 medicine

Sperm Telomere Length and Its Correlation with Semen Parameters and Chromatin Protamination Across Semen Phenotypes in Infertile Men

This study demonstrates that while sperm telomere length shows no significant correlation with conventional semen parameters, chromatin protamination serves as the sole independent predictor of telomere length, revealing hidden molecular defects in normozoospermic men and highlighting its utility as a functional biomarker for paternal genomic integrity in fertility assessments.

Swathy Yuvaraj, Radha Vembu, Teena Koshy, Yamini Asokan2026-10-11