4321 papers
This paper proposes a methodological framework and eleven candidate items for a SPIRIT-Ayurveda extension to address transparency gaps in whole-system Ayurvedic trials by integrating open-science principles and standardizing protocol reporting to bridge Ayurvedic epistemology with global evidentiary standards.
This systematic review and meta-analysis of 21 studies suggests that while physical activity significantly improves psychological wellbeing and aerobic fitness in adults recovering from alcohol dependence, its direct impact on reducing alcohol consumption remains uncertain due to methodological limitations and low-certainty evidence.
This study demonstrates that combining serum CA19-9 levels with specific contrast-enhanced CT features, particularly the arterial phase tumor-to-pancreas enhancement ratio and pancreatic duct status, effectively differentiates pancreatic neuroendocrine carcinoma from pancreatic ductal adenocarcinoma.
This study of 1,093 type 2 diabetes patients reveals that a higher uric acid to high-density lipoprotein cholesterol ratio (UHR) is significantly associated with a lower risk of low muscle mass, suggesting UHR could serve as a valuable metabolic indicator for sarcopenia in this population.
This retrospective analysis of 4,002 severe spinal cord injury patients from the TraumaRegister DGU® reveals that neurogenic shock, defined by hypotension and bradycardia, affects 12.3% of cases—particularly in the elderly with cervical injuries—and is associated with significantly higher mortality rates that have remained unchanged over 15 years, highlighting an urgent need for improved early recognition and targeted hemodynamic management.
This study reveals that while third-year medical students and general surgery residents share aligned expectations on many core clerkship duties, significant discrepancies exist regarding patient load, leadership of orientation, and operative participation, highlighting a need for intervention to improve role clarity and satisfaction.
This retrospective study of 400 patients with recurrent and metastatic head and neck cancer found that interstitial lung disease occurred more frequently with immune checkpoint inhibitor therapy (particularly when combined with cetuximab or paclitaxel) and was independently associated with heavy smoking and a history of stroke, yet paradoxically correlated with improved long-term survival.
The paper introduces OrthoPilot, an AI system powered by large language models that integrates real-time hospital data with external medical knowledge to enable evidence-based longitudinal management of musculoskeletal care, demonstrating superior performance to expert physicians and significant improvements in clinical outcomes across multiple real-world studies.
This study demonstrates that while both 6.0–6.5 mm and 6.6–7.0 mm optical zones in ray-tracing-guided FS-LASIK yield comparable refractive accuracy and visual acuity, the larger zone significantly reduces postoperative higher-order aberrations, thereby improving overall optical quality.
This study analyzes suicide mortality trends across 12 South American countries from 2000 to 2021 using joinpoint regression, revealing diverse, country-specific trajectories with significant sex disparities and no evidence of a pandemic-related increase, while highlighting the need for enhanced surveillance in nations with rising rates like Paraguay and Brazil.