📄 medicine

Care pathway factors associated with death among patients with severe malaria in selected hospitals in Ghana: a multicentre unmatched case-control study

This multicentre case-control study in Ghana identifies that deaths among severe malaria patients are significantly associated with failures in triage and timely parenteral treatment, delays in referral and blood transfusion, and barriers related to residence outside the admitting district and lack of health insurance.

Ernest Kenu, Keziah L. Malm, Nana Yaw Peprah, Abdul Gafaru Mohammed, George Asumah Adu, Paul Boateng, Dora Dadzie, Mary (…)2026-10-12
📄 medicine

Leveraging Interpretable Machine Learning Models and National Risk Stratification for Postnatal Anemia in Ethiopia: A Secondary Analysis of the 2024–25 Demographic and Health Survey

This study utilizes a secondary analysis of the 2024–25 Ethiopian Demographic and Health Survey to demonstrate that an interpretable Random Forest machine learning model can accurately predict postnatal anemia severity using key determinants like BMI and antenatal care, offering a scalable tool for targeted clinical interventions in Ethiopia.

Ashebir Mamay Gebiru, Solomon Tibebu Ambelie, Serku Abate Mihret, Yenehun Demelash Gelaw2026-10-12
📄 medicine

Prognostic and Immune Microenvironment Significance of Opioid Receptor- and Pain-Related Gene Signatures in Gastric and Colorectal Cancer

This study identifies a gene signature comprising opioid receptor- and pain-related genes (specifically CNR1 and TRPV1) that serves as an independent prognostic indicator for overall survival and reflects specific inflammatory immune microenvironment states in gastric and colorectal cancers, though its clinical utility requires further prospective validation and functional investigation.

Zhaolong Zhao, Jing Liang, Kun Wu, Jingge Cheng, Danmei Li, Hemei Wang2026-10-12
📄 medicine

ATLAS: Development and Evaluation of an AI -Enabled Framework for Anatomically Traceable Measurement Assurance in Fetal-Head Ultrasound Biometry

The ATLAS framework introduces a compact, evidence-traceable AI system for fetal-head ultrasound biometry that integrates data integrity checks, anatomical verification, and dual measurement methods to ensure accurate, auditable, and clinically trustworthy gestational assessments.

Dian Tjondronegoro, Elizabeth Irenne Yuwono, Fabricio da Silva Costa2026-10-12
📄 medicine

Knowledge and Practice of Contraception Among Male Adolescents of High Schools in Kathmandu Metropolitan City

A cross-sectional study of 384 male high school students in Kathmandu revealed unsatisfactory levels of contraceptive knowledge and limited parent-adolescent communication, highlighting an urgent need for comprehensive sexual health education and improved dialogue, particularly among younger students in government schools.

Sumit Bohara¹, Rojina Dahal¹, Subhash Bhusal¹, Menuka Bohara, Rajan Paudel¹2026-10-12
📄 medicine

Facilitators and Barriers to Elimination of Mother-to-Child Transmission of HIV (eMTCT) at a Tertiary Hospital in Uganda: A Qualitative Study

This qualitative study at Masaka Regional Referral Hospital in Uganda, guided by the COM-B framework, identifies key health system, individual, sociocultural, and structural facilitators and barriers—ranging from integrated services and peer support to stockouts, stigma, and poverty—that influence the elimination of mother-to-child HIV transmission.

Emma Amadriyo, David Christopher Mukasa, Nelson Kalema, Pebalo Francis Pebolo, Joanita Nangendo, Fred C. Semitala, Susan (…)2026-10-12
📄 medicine

A Study on the Application of Multimodal MRI Deep Learning in the Early Detection of Osteonecrosis of the Femoral Head

This study demonstrates that a YOLO v11 deep learning model utilizing multimodal MRI fusion (T1WI and T2WI) achieves superior accuracy and real-time inference speeds for the early detection of osteonecrosis of the femoral head, offering a robust tool for clinical decision support.

Wang Xingru, Liu Kai, Zhang Liwei, Ma Chao, Meng Lingting, Liu Jianming, Xiao Hongxin, Liu Guangwen, Cao Yuju, Wang Jian (…)2026-10-12
📄 medicine

MMP8⁺ cells in peripheral blood mononuclear cells as an independent prognostic marker of 60-day mortality in sepsis: a prospective observational cohort study

This prospective observational cohort study demonstrates that the proportion of MMP8⁺ cells within peripheral blood mononuclear cells is an independent prognostic marker for 60-day mortality in sepsis patients, offering improved risk reclassification beyond standard clinical variables.

Ze Chen¹#, Xiaoyan Chen²#, Lu Ceng¹, Buyu Wang¹, Yang Lu³, Yunhan Sun⁴, Li Li⁴, Guangju Zhao¹2026-10-12