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medicine

14263 papers

📄 medicine

The Lived Experience of Chinese Patients With Somatic Symptom Disorder: An Interpretative Phenomenological Analysis

This study utilizes Interpretative Phenomenological Analysis to explore the lived experiences of eight Chinese patients with Somatic Symptom Disorder, revealing that their symptoms stem from a fear of death and an unsafe worldview, and recommending that clinicians address these underlying psychological drivers through empathic validation and cognitive reframing rather than redundant physical investigations.

Yihan Xue, Fazhan Chen2026-10-11
📄 medicine

Metabolic Syndrome and the Risk of Depression and Anxiety: A Prospective Cohort Study

This prospective cohort study of over 316,000 participants demonstrates that metabolic syndrome significantly increases the risk of developing new-onset depression and anxiety through a dose-response relationship, with central obesity and low HDL cholesterol being key drivers and systemic inflammation partially mediating this association.

Siyi Shen, Xinmeng Yao, Qixin Zhang, Ziyi Huang, Jiayu Li, Fei Pan, Yingying Mao, Xian Zhang2026-10-11
📄 medicine

Evaluation of Hospital Preparedness and Response to Trauma Through a Full-Scale Disaster Drill: A Multimethod Study

This multimethod study evaluating a hospital's full-scale trauma disaster drill found that while frontline clinical triage was effective, systemic inefficiencies in communication, command coordination, and resource logistics significantly hindered the overall mass casualty response.

Kripa Maharjan, Aakash Bhandari, Aayush Chaulagain, Shruti Silwal, Mala Deep Upadhaya, Amit Chand2026-10-11
📄 medicine

Cardiopulmonary phenotypes as markers of high risk in patients with COPD in primary care: the MASTER-EPOC study

The MASTER-EPOC study demonstrates that integrating exacerbation profiles with cardiovascular risk in primary care COPD patients reveals clinically distinct phenotypes, including a "hidden-risk" group of non-exacerbators with cardiovascular disease who face significantly higher hospitalization rates and poorer disease control.

Alberto Calderón-Montero, Raul Alonso-Avilés, Ancor Sanz-García, Martínez-Tahoces Sheila, Cristina Millares-López, Mirel (…)2026-10-11
📄 medicine

Endothelium-in hydrodissection (Muraine) versus endothelium-out stripping graft preparation for Descemet Membrane Endothelial Keratoplasty: a prospective two-centre cohort study

This prospective two-centre cohort study found that while the Muraine endothelium-in hydrodissection technique for DMEK offers faster graft unfolding and equivalent early visual and endothelial outcomes compared to the standard endothelium-out method, it is associated with longer dissection times, higher rates of partial tissue loss, increased 6-month endothelial cell loss, and a significantly greater need for rebubbling due to air-only tamponade.

Eduard Pedemonte-Sarrias, Antoni Salvador, José Luis Güell, Irene Sassot, Oscar Gris, José García-Arumí2026-10-11
📄 medicine

Depressive and PTSD symptoms are associated with regional differences in light-evoked brain responses in chronic ocular pain

This study reveals that individuals with chronic ocular pain who also exhibit depressive or PTSD symptoms display distinct regional differences in light-evoked brain responses compared to those without such comorbidities, suggesting that mental health status contributes to heterogeneity in central pain processing and may inform more targeted treatment strategies.

Eric Moulton, Ema Karakoleva, David Valdes-Arias, Pradip Pattany, Vanda Faria, Elizabeth Helix, Anat Galor2026-10-11
📄 medicine

Prognostic Role of HALP Score, CALLY Index, and Prognostic Nutritional Index in Polytrauma Patients Followed in the Intensive Care Unit: A Retrospective Cohort Study

In a retrospective cohort study of 162 ICU polytrauma patients, the Prognostic Nutritional Index (PNI) was identified as the only independent predictor of in-hospital mortality among the evaluated immunological and nutritional scores, outperforming both the CALLY index and HALP score.

Kadir ARSLAN, Aysun EDEHAN, Hale Cetin Arslan, Ayca Sultan Sahin2026-10-11
📄 medicine

EGFR tyrosine kinase inhibitor receipt and overall survival in metastatic non-small cell lung cancer in Egypt A retrospective descriptive cohort study

This retrospective cohort study of 99 Egyptian patients with EGFR-mutated metastatic non-small cell lung cancer found that while 73.7% received EGFR tyrosine kinase inhibitors, the resulting survival estimates are limited by heavy censoring and missing outcomes among untreated patients, preventing definitive conclusions on treatment effects or population-level access.

Esraa Jamal Moustafa Jamal, Nourin Ali Sharief, Manar Hamed Ahmed, Ahmed M. Elalfy2026-10-11
📄 medicine

A Single Arm Pilot Study to Evaluate the Safety, Feasibility, and Dose Ranging of Splenic Nerve Stimulation in Patients with Rheumatoid Arthritis Using a Novel Implantable Device

This single-arm pilot study demonstrated that laparoscopic implantation of a novel device for splenic nerve stimulation in patients with refractory rheumatoid arthritis was feasible and safe, with preliminary evidence suggesting potential reductions in disease activity and inflammatory biomarkers in some participants.

Jeroen Christiaans, Michael Reed, Neil Basu, Nigel B. Jamieson, Misha D.P. Luyer, Aysin Tulunay Virlan, Carl S. Goodyear (…)2026-10-11